A protocol of Chinese expert consensuses for the management of health risk in the general public

IntroductionNon-communicable diseases (NCDs) represent the leading cause of mortality and disability worldwide. Robust evidence has demonstrated that modifiable lifestyle factors such as unhealthy diet, smoking, alcohol consumption and physical inactivity are the primary causes of NCDs. Although a series of guidelines for the management of NCDs have been published in China, these guidelines mainly focus on clinical practice targeting clinicians rather than the general population, and the evidence for NCD prevention based on modifiable lifestyle factors has been disorganized. Therefore, comprehensive and evidence-based guidance for the risk management of major NCDs for the general Chinese population is urgently needed. To achieve this overarching aim, we plan to develop a series of expert consensuses covering 15 major NCDs on health risk management for the general Chinese population. The objectives of these consensuses are (1) to identify and recommend suitable risk assessment methods for the Chinese population; and (2) to make recommendations for the prevention of major NCDs by integrating the current best evidence and experts’ opinions.Methods and analysisFor each expert consensus, we will establish a consensus working group comprising 40–50 members. Consensus questions will be formulated by integrating literature reviews, expert opinions, and an online survey. Systematic reviews will be considered as the primary evidence sources. We will conduct new systematic reviews if there are no eligible systematic reviews, the methodological quality is low, or the existing systematic reviews have been published for more than 3 years. We will evaluate the quality of evidence and make recommendations according to the GRADE approach. The consensuses will be reported according to the Reporting Items for Practice Guidelines in Healthcare (RIGHT)

Application of heat pump combined two-stage desiccant wheel fresh air system of residential buildings in mixed climate zone

The building requires dehumidification for a long period of time in mixed climate zone of China. As a conventional method for dehumidification, vapor compression systems remove the water vapor by cooling the process air below dew point. This system consumes a lot of energy for reheating the air to meet the requirement of supply air temperature. A heat pump combined with two-stage desiccant wheel (TSDW&HP) is proposed as an air conditioning and dehumidification system in this study. The operation performance of proposed system applied in a hypothetical residence with 3 residents was investigated and simulated by using TRNSYS software. The operation modes of the system are discussed for different scenarios of season and outdoor air humidity ratio. In dehumidification season, fresh air deals with all of the latent load. In air conditioning season, fresh air deals with all of the moisture load with part of the cooling load. When evaporation temperature of HP is reduced and more moisture load is processed by evaporator in air conditioning season, there is a balance point between the performance of DWs and heat pump. The energy consumption of TSDW&HP fresh air system was compared with a conventional fresh air conditioner during dehumidification season and air conditioning season. It was found that the energy-saving potential of this system is 27.3% compared with conventional air conditioner

Study on the Dynamics of Microflora during Natural Fermentation of Different Blueberry Wines

Microflora play an important role in the fermentation of blueberry wine, influencing the flavor and nutrient formation. Commercial yeasts give blueberry wines an average flavor profile that does not highlight the specific aroma and origin of the blueberry. In the present study, ITS1-ITS2 region sequencing analysis was performed using Illumina MiSeq high-throughput technology to sequence fermented blueberry wine samples of three Vaccinium ashei varieties, Gardenblue, Powderblue, and Britewell, from the Majiang appellation in Guizhou province to analyze the trends of fungal communities and the diversity of compositional structures in different periods of blueberry wine fermentation. The study’s results revealed that 114 genera from seven phyla were detected in nine samples from different fermentation periods of blueberry wine. The main fungal phyla were Ascomycota, Basidiomycota, Kickxellomycota, Chytridiomycota, and Olpidiomycota. The main fungal genera were Hanseniaspora, Saccharomyces, unidentified, Aureobasidium, Penicillium, Mortierella, Colletotrichum, etc. Hanseniaspora was dominant in the pre-fermentation stage of blueberry wine, accounting for more than 82%; Saccharomyces was the dominant genera in the middle and late fermentation stages of blueberry wine, with Saccharomyces accounting for more than 72% in the middle of fermentation and 93% in the late fermentation stage. This study screened indigenous flora for the natural fermentation of blueberry wine in the Majiang production area of Guizhou, improved the flavor substances of the blueberry wine, highlighted the characteristics of the production area, and made the blueberry wine have the characteristic flavor of the production area

The climate adaptability evaluation of biogas fermentation assisted by solar greenhouse

The production efficiency of biogas digesters is largely restricted by the low environment temperature in winter, for most regions of China. As a feasible means of warming and heat preservation, solar greenhouse has the ability to expand the application scope and service time of biogas in rural China. The evaluation of climate adaptability of solar greenhouse is of great importance and imminent, due to the fact that both solar energy and biomass resources are affected by climate. In this paper, a complete evaluation index system for climate adaptability of biogas fermentation assisted by solar greenhouse was established. The indicators of the evaluation index system were selected by means of frequency analysis and theoretical analysis. The weights of the indicators, including solar radiation, outdoor air temperature, crop yields and human and animal manure, were determined by analytic hierarchy process combined with literature research, and the scoring rules were based on the objective significance of each indicator. The climate adaptability of typical cities in the Yangtze River Delta was evaluated with the evaluation index system. Among the cities, Hefei shows the best comprehensive adaptability, and then is Xuzhou, Shanghai, Nanjing, and the lowest adaptability, Hangzhou. The comprehensive adaptability results of these cities depend not only on the gas production capacity, but also on the biomass resource and solar radiation

The effect of biogas fermentation assisted by simple solar greenhouse

Biogas fermentation rate is largely affected by environment temperature, causing a much more difficult production of biogas digesters in cold winter, for most regions in China. Combining the abundant solar energy resources and biomass dry anaerobic fermentation together, solar thermal energy can guarantee the production of biogas in winter. With this method, the prediction of the appropriate fermentation temperature is required. In this study, the effect of temperature on biogas fermentation was studied. To predict the fermentation temperature, a heat transfer model of biogas fermentation based on a project in city Xuzhou, which assisted with a simple solar greenhouse, was established according to the heat transfer theory. The maximum difference between the measured and calculated fermentation temperature was 2%. The effect of biogas fermentation assisted by simple solar greenhouse in typical city of different climate zones, including severe cold region, cold region and hot summer and cold winter region, was studied with the combination of heat transfer model and temperature-based biogas production rates prediction model. The results showed that, the gas production rate of biogas fermentation increases with the increase of temperature in a certain range. Assisted by simple solar greenhouse, the biogas digester temperature is increased by 6~8°C compared with the previous one, ensuring a better daily gas production rate of 0.5~0.7m3/m3 in winter

Transcription Factor PAX6 (Paired Box 6) Controls Limbal Stem Cell Lineage in Development and Disease*

PAX6 is a master regulatory gene involved in neuronal cell fate specification. It also plays a critical role in early eye field and subsequent limbal stem cell (LSC) determination during eye development. Defects in Pax6 cause aniridia and LSC deficiency in humans and the Sey (Small eye) phenotype in mice (Massé, K., Bhamra, S., Eason, R., Dale, N., and Jones, E. A. (2007) Nature 449, 1058-1062). However, how PAX6 specifies LSC and corneal fates during eye development is not well understood. Here, we show that PAX6 is expressed in the primitive eye cup and later in corneal tissue progenitors in early embryonic development. In contrast, p63 expression commences after that of PAX6 in ocular adnexal and skin tissue progenitors and later in LSCs. Using an in vitro feeder-free culture system, we show that PAX6 knockdown in LSCs led to up-regulation of skin epidermis-specific keratins concomitant with differentiation to a skin fate. Using gene expression analysis, we identified the involvement of Notch, Wnt, and TGF-β signaling pathways in LSC fate determination. Thus, loss of PAX6 converts LSCs to epidermal stem cells, as demonstrated by a switch in the keratin gene expression profile and by the appearance of congenital dermoid tissue

Transcription Factor PAX6 (Paired Box 6) Controls Limbal Stem Cell Lineage in Development and Disease

PAX6 is a master regulatory gene involved in neuronal cell fate specification. It also plays a critical role in early eye field and subsequent limbal stem cell (LSC) determination during eye development. Defects in Pax6 cause aniridia and LSC deficiency in humans and the Sey (Small eye) phenotype in mice (Massé, K., Bhamra, S., Eason, R., Dale, N., and Jones, E. A. (2007) Nature 449, 1058–1062). However, how PAX6 specifies LSC and corneal fates during eye development is not well understood. Here, we show that PAX6 is expressed in the primitive eye cup and later in corneal tissue progenitors in early embryonic development. In contrast, p63 expression commences after that of PAX6 in ocular adnexal and skin tissue progenitors and later in LSCs. Using an in vitro feeder-free culture system, we show that PAX6 knockdown in LSCs led to up-regulation of skin epidermis-specific keratins concomitant with differentiation to a skin fate. Using gene expression analysis, we identified the involvement of Notch, Wnt, and TGF-β signaling pathways in LSC fate determination. Thus, loss of PAX6 converts LSCs to epidermal stem cells, as demonstrated by a switch in the keratin gene expression profile and by the appearance of congenital dermoid tissue

ATLAS

% ATLAS \\ \\ ATLAS is a general-purpose experiment for recording proton-proton collisions at LHC. The ATLAS collaboration consists of 144 participating institutions (June 1998) with more than 1750~physicists and engineers (700 from non-Member States). The detector design has been optimized to cover the largest possible range of LHC physics: searches for Higgs bosons and alternative schemes for the spontaneous symmetry-breaking mechanism; searches for supersymmetric particles, new gauge bosons, leptoquarks, and quark and lepton compositeness indicating extensions to the Standard Model and new physics beyond it; studies of the origin of CP violation via high-precision measurements of CP-violating B-decays; high-precision measurements of the third quark family such as the top-quark mass and decay properties, rare decays of B-hadrons, spectroscopy of rare B-hadrons, and $B ^0 _{s}$-mixing. \\ \\The ATLAS dectector, shown in the Figure includes an inner tracking detector inside a 2~T~solenoid providing an axial field, electromagnetic and hadronic calorimeters outside the solenoid and in the forward regions, and barrel and end-cap air-core-toroid muon spectrometers. The precision measurements for photons, electrons, muons and hadrons, and identification of photons, electrons, muons, $\tau$-leptons and b-quark jets are performed over $| \eta |$ < 2.5. The complete hadronic energy measurement extends over $| \eta |$ < 4.7. \\ \\The inner tracking detector consists of straw drift tubes interleaved with transition radiators for robust pattern recognition and electron identification, and several layers of semiconductor strip and pixel detectors providing high-precision space points. \\ \\The e.m. calorimeter is a lead-Liquid Argon sampling calorimeter with an integrated preshower detector and a presampler layer immediately behind the cryostat wall for energy recovery. The end-cap hadronic calorimeters also use Liquid Argon technology, with copper absorber plates. The end-cap cryostats house the e.m., hadronic and forward calorimeters (tungsten-Liquid Argon sampling). The barrel hadronic calorimeter is an iron-scintillating tile sampling calorimeter with longitudinal tile geometry. \\ \\Air-core toroids are used for the muon spectrometer. Eight superconducting coils with warm voussoirs are used in the barrel region complemented with superconducting end-cap toroids in the forward regions. The toroids will be instrumented with Monitored Drift Tubes (Cathode Strip Chambers at large rapidity where there are high radiation levels). The muon trigger and second coordinate measurement for muon tracks are provide