New directions for old drugs

With the beneficial goal of generating new applications from known drugs, the chemistry and biology groups of Dr. Martin J. Lear and Prof. Yao Shao Qin have teamed up to develop an anti-cancer agent out of the FDA-approved anti-obesity drug called Orlistat (also known as tetrahydrolipstatin, THL). Their strategy combines the techniques of total synthesis and chemical proteomics to generate THL-probes capable of trapping off-target proteins

Perceptually Motivated Wavelet Packet Transform for Bioacoustic Signal Enhancement

A significant and often unavoidable problem in bioacoustic signal processing is the presence of background noise due to an adverse recording environment. This paper proposes a new bioacoustic signal enhancement technique which can be used on a wide range of species. The technique is based on a perceptually scaled wavelet packet decomposition using a species-specific Greenwood scale function. Spectral estimation techniques, similar to those used for human speech enhancement, are used for estimation of clean signal wavelet coefficients under an additive noise model. The new approach is compared to several other techniques, including basic bandpass filtering as well as classical speech enhancement methods such as spectral subtraction, Wiener filtering, and Ephraim–Malah filtering. Vocalizations recorded from several species are used for evaluation, including the ortolan bunting (Emberiza hortulana), rhesus monkey (Macaca mulatta), and humpback whale (Megaptera novaeanglia), with both additive white Gaussian noise and environment recording noise added across a range of signal-to-noise ratios (SNRs). Results, measured by both SNR and segmental SNR of the enhanced wave forms, indicate that the proposed method outperforms other approaches for a wide range of noise conditions

The influence of net-quarks on the yields and rapidity spectra of identified hadrons

Within a quark combination model, we study systematically the yields and rapidity spectra of various hadrons in central Au+Au collisions at $\sqrt{s_{NN}}= 200$ GeV. We find that considering the difference in rapidity between net-quarks and newborn quarks, the data of multiplicities, rapidity distributions for $\pi^{\pm}$, $K^{\pm}$, $p(\bar{p})$ and, in particular the ratios of charged antihadron to hadron as a function of rapidity, can be well described. The effect of net-quarks on various hadrons is analysed, and the rapidity distributions for $K^{0}_{s}$, $\Lambda(\bar{\Lambda})$, $\Sigma^{+}(\bar{\Sigma}^{_-})$, $\mathrm{\Xi^{-}}$ ($\mathrm{\bar{\Xi}^{_+}}$) and $\mathrm{\Omega^{-}}(\mathrm{\bar{\Omega}}^{_+})$ are predicted. We discuss the rapidity distribution of net-baryon, and find that it reflects exactly the energy loss of colliding nuclei.Comment: 8 pages, 7 figure

Centrality dependence of pTp_{T} spectra for identified hadrons in Au+Au and Cu+Cu collisions at sNN=200\sqrt{s_{NN}}= 200 GeV

The centrality dependence of transverse momentum spectra for identified hadrons at midrapidity in Au+Au collisions at $\sqrt{s_{NN}}= 200$ GeV is systematically studied in a quark combination model. The $\mathrm{{p}_{T}}$ spectra of $\pi^{\pm}$, $K^{\pm}$, $p(\bar{p})$ and $\Lambda(\bar{\Lambda})$ in different centrality bins and the nuclear modification factors ($R_{CP}$) for these hadrons are calculated. The centrality dependence of the average collective transverse velocity $$ for the hot and dense quark matter is obtained in Au+Au collisions, and it is applied to a relative smaller Cu+Cu collision system. The centrality dependence of $\mathrm{{p}_{T}}$ spectra and the $R_{CP}$ for $\pi^{0}$, $K_{s}^{0}$ and $\Lambda$ in Cu+Cu collisions at $\sqrt{s_{NN}}= 200$ GeV are well described. The results show that $<\beta (r)>$ is only a function of the number of participants $N_{part}$ and it is independent of the collision system.Comment: 7 pages, 6 figure

Fluorescence-activated cell sorting and directed evolution of α-N-acetylgalactosaminidases using a quenched activity-based probe (qABP)

10.1039/C3CC42836BChemical Communications49657237-723

An Investigation of Hadronization Mechanism at Z0Z^{0} Factory

We briefly review the hadronization pictures adopted in the LUND String Fragmentation Model(LSFM), Webber Cluster Fragmentation Model(WCFM) and Quark Combination Model(QCM), respectively. Predictions of hadron multiplicity, baryon to meson ratios and baryon-antibaryon flavor correlations, especially related to heavy hadrons at $Z^0$ factory obtained by LSFM and QCM are reported.Comment: 18 pages, 6 figures. accepted by Sci China Phys Mech Astro

Supersymmetric t-J Gaudin Models and KZ Equations

Supersymmetric t-J Gaudin models with both periodic and open boundary conditions are constructed and diagonalized by means of the algebraic Bethe ansatz method. Off-shell Bethe ansatz equations of the Gaudin systems are derived, and used to construct and solve the KZ equations associated with $sl(2|1)^{(1)}$ superalgebra.Comment: LaTex 21 page

Dynamic Dual-Attentive Aggregation Learning for Visible-Infrared Person Re-identification

© 2020, Springer Nature Switzerland AG. Visible-infrared person re-identification (VI-ReID) is a challenging cross-modality pedestrian retrieval problem. Due to the large intra-class variations and cross-modality discrepancy with large amount of sample noise, it is difficult to learn discriminative part features. Existing VI-ReID methods instead tend to learn global representations, which have limited discriminability and weak robustness to noisy images. In this paper, we propose a novel dynamic dual-attentive aggregation (DDAG) learning method by mining both intra-modality part-level and cross-modality graph-level contextual cues for VI-ReID. We propose an intra-modality weighted-part attention module to extract discriminative part-aggregated features, by imposing the domain knowledge on the part relationship mining. To enhance robustness against noisy samples, we introduce cross-modality graph structured attention to reinforce the representation with the contextual relations across the two modalities. We also develop a parameter-free dynamic dual aggregation learning strategy to adaptively integrate the two components in a progressive joint training manner. Extensive experiments demonstrate that DDAG outperforms the state-of-the-art methods under various settings

Rapidity dependence of hadron production in central Au+Au collisions at sNN=200\sqrt{s_{NN}}= 200 GeV

The rapidity and transverse momentum spectra for identified hadrons in central Au+Au collisions at $\sqrt{s_{NN}}= 200$ GeV are computed in a quark combination model. The data of rapidity distributions for $\pi^{\pm}$, $K^{\pm}$, $p(\bar{p})$ and net protons $(p-\bar{p})$ are well described. We also predict rapidity distributions for $K^{0}_{s}$, $\Lambda(\bar{\Lambda})$, $\mathrm{\Xi^{-}}$ ($\mathrm{\bar{\Xi}^{_+}}$) and $\mathrm{\Omega^{-}}+\mathrm{\bar{\Omega}}^{_+}$. The multiplicity ratios of charged antihadrons to hadrons as a function of rapidity are reproduced. The results for ${p}_{T}$ spectra of $\pi^{\pm}$, $K^{\pm}$, $p(\bar{p})$ and for the $p/\pi$ ratios in a broader ${p}_{T}$ range agree well with the data. Finally the rapidity dependence of transverse momentum distributions for hadrons are given.Comment: 10 pages,11figures,3 table

Variability, polarimetry, and timing properties of single pulses from PSR J2222-0137 using FAST

In our work, we analyse $5\times10^{4}$ single pulses from the recycled pulsar PSR J2222$-$0137 in one of its scintillation maxima observed by the Five-hundred-meter Aperture Spherical radio Telescope (FAST). PSR J2222$-$0137 is one of the nearest and best studies of binary pulsars and a unique laboratory for testing gravitational theories. We report single pulses' energy distribution and polarization from the pulsar's main-pulse region. The single pulse energy follows the log-normal distribution. We resolve a steep polarization swing, but at the current time resolution ($64\,\mu{\rm s}$), we find no evidence for the orthogonal jump in the main-pulse region, as has been suspected. We find a potential sub-pulse drifting period of $P_{3} \sim 3.5\,P$. We analyse the jitter noise from different integrated numbers of pulses and find that its $\sigma_{j}$ is $270\pm{9}\,{\rm ns}$ for 1-hr integration at 1.25 GHz. This result is useful for optimizing future timing campaigns with FAST or other radio telescopes.Comment: 11 pages, 14 figures, accepted by Monthly Notices of the Royal Astronomical Societ