Respiratory hospitalizations in association with fine PM and its components in New York State

<div><p>Despite observed geographic and temporal variation in particulate matter (PM)-related health morbidities, only a small number of epidemiologic studies have evaluated the relation between PM_2.5 chemical constituents and respiratory disease. Most assessments are limited by inadequate spatial and temporal resolution of ambient PM measurements and/or by their approaches to examine the role of specific PM components on health outcomes. In a case-crossover analysis using daily average ambient PM_2.5 total mass and species estimates derived from the Community Multiscale Air Quality (CMAQ) model and available observations, we examined the association between the chemical components of PM (including elemental and organic carbon, sulfate, nitrate, ammonium, and other remaining) and respiratory hospitalizations in New York State. We evaluated relationships between levels (low, medium, high) of PM constituent mass fractions, and assessed modification of the PM_2.5–hospitalization association via models stratified by mass fractions of both primary and secondary PM components. In our results, average daily PM_2.5 concentrations in New York State were generally lower than the 24-hr average National Ambient Air Quality Standard (NAAQS). Year-round analyses showed statistically significant positive associations between respiratory hospitalizations and PM_2.5 total mass, sulfate, nitrate, and ammonium concentrations at multiple exposure lags (0.5–2.0% per interquartile range [IQR] increase). Primarily in the summer months, the greatest associations with respiratory hospitalizations were observed per IQR increase in the secondary species sulfate and ammonium concentrations at lags of 1–4 days (1.0–2.0%). Although there were subtle differences in associations observed between mass fraction tertiles, there was no strong evidence to support modification of the PM_2.5-respiratory disease association by a particular constituent. We conclude that ambient concentrations of PM_2.5 and secondary aerosols including sulfate, ammonium, and nitrate were positively associated with respiratory hospitalizations, although patterns varied by season. Exposure to specific fine PM constituents is a plausible risk factor for respiratory hospitalization in New York State.</p><p>Implications: <i>The association between ambient concentrations of PM_2.5 components has been evaluated in only a small number of epidemiologic studies with refined spatial and temporal scale data. In New York State, fine PM and several of its constituents, including sulfate, ammonium, and nitrate, were positively associated with respiratory hospitalizations. Results suggest that PM species relationships and their influence on respiratory endpoints are complex and season dependent. Additional work is needed to better understand the relative toxicity of PM species, and to further explore the role of co-pollutant relationships and exposure prediction error on observed PM–respiratory disease associations.</i></p></div

Data and Code for Mysteriously rapid rise in Legionnaires' disease incidence correlates with declining atmospheric sulfur dioxide

Data and code for the analyses and figures presented in the paper titled "Mysteriously rapid rise in Legionnaires' disease incidence correlates with declining atmospheric sulfur dioxide".</p

Additional file 1: of Attitudes towards suicide in urban and rural China: a population based, cross-sectional study

Appendix 1. Scale of Public Attitudes about Suicide (SPAS) (translated from the original Chinese). (DOCX 16 Kb