Electroweak Chiral Lagrangian for a Hypercharge-universal Topcolor Model

Electroweak chiral Lagrangian for a hypercharge-universal topcolor model is investigated. We find that the assignments of universal hypercharge improve the results obtained previously from K.Lane's prototype natural TC2 model by allowing a larger Z' mass resulting in a very small T parameter and the S parameter is still around the order of +1Comment: 12 pages, 7 figure

Weyl points and topological nodal superfluids in a face-centered cubic optical lattice

We point out that a face-centered cubic (FCC) optical lattice, which can be realised by a simple scheme using three lasers, provides one a highly controllable platform for creating Weyl points and topological nodal superfluids in ultracold atoms. In non-interacting systems, Weyl points automatically arise in the Floquet band structure when shaking such FCC lattices, and sophisticated design of the tunnelling is not required. More interestingly, in the presence of attractive interaction between two hyperfine spin states, which experience the same shaken FCC lattice, a three-dimensional topological nodal superfluid emerges, and Weyl points show up as the gapless points in the quasiparticle spectrum. One could either create a double Weyl point of charge 2, or split it to two Weyl points of charge 1, which can be moved in the momentum space by tuning the interactions. Correspondingly, the Fermi arcs at the surface may be linked with each other or separated as individual ones.Comment: 5 pages, 2 figures in the main text; 2 pages, 2 figures in the supplemental materia

Familial hypomagnesaemia, Hypercalciuria and Nephrocalcinosis associated with a novel mutation of the highly conserved leucine residue 116 of Claudin 16 in a Chinese patient with a delayed diagnosis: A case report

Background: Sixty mutations of claudin 16 coding gene have been reported in familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) patients. Recent investigations revealed that a highly conserved glycine-leucine-tryptophan (115G-L-W117) motif in the first extracellular segment (ESC1) of claudin 16 might be essential for stabilization of the appropriately folded ECS1 structure and conservation of normal claudin 16 function. However, neither missense nor nonsense mutation has ever been described in this motif. Our study aimed at identifying mutations in a Chinese patient with FHHNC and exploring the association between genotype and phenotype. Case presentation: A 33-year-old female presented with 4 years history of recurrent acute pyelonephritis without other notable past medical history. Her healthy parents, who aged 56 and 53 respectively, were second cousins, and her only sibling died from renal failure without definite cause at age 25. Renal ultrasound imaging demonstrated atrophic kidneys and bilateral nephrocalcinosis. The laboratory workup revealed impaired renal function (Stage CKD IV), hypocalcemia and mild hypomagnesemia, accompanied with marked renal loss of magnesium and hypercalciuria. During the follow-up, treatment with calcitriol and calcium but not with magnesium was difficult to achieve normal serum calcium levels, whereas her serum magnesium concentration fluctuated within normal ranges. In the end, the patient unavoidably reached ESRD at 36 years old. The clinical features and family history suggested the diagnosis of FHHNC. To make a definite diagnosis, we use whole-exome sequencing to identify the disease-causing mutations and Sanger sequencing to confirm the mutation co-segregation in the family. As a result, a novel homozygous mutation (c.346C > G, p.Leu116Val) in115G-L-W117motif of claudin 16 was identified. Her parents, grandmother and one of her cousins carried heterozygous p.Leu116Val, whereas 200 unrelated controls did not carry this mutation. Conclusions: We described a delayed diagnosis patient with FHHNC in the Chinese population and identified a novel missense mutation in the highly conserved115G-L-W117motif of claudin 16 for the first time. According to the reported data and the information deduced from 3D modeling, we speculate that this mutation probably reserve partial residual function which might be related to the slight phenotype of the patient

Dynamical Computation on Coefficients of Electroweak Chiral Lagrangian from One-doublet and Topcolor-assisted Technicolor Models

Based on previous studies deriving the chiral Lagrangian for pseudo scalar mesons from the first principle of QCD, we derive the electroweak chiral Lagrangian and build up a formulation for computing its coefficients from one-doublet technicolor model and a schematic topcolor-assisted technicolor model. We find that the coefficients of the electroweak chiral Lagrangian for the topcolor-assisted technicolor model are divided into three parts: direct TC2 interaction part, TC1 and TC2 induced effective Z' particle contribution part, and ordinary quarks contribution part. The first two parts are computed in this paper and we show that the direct TC2 interaction part is the same as that in the one-doublet technicolor model, while effective Z' contributions are at least proportional to the p^2 order parameter \beta_1 in the electroweak chiral Lagrangian and typical features of topcolor-assisted technicolor model are that it only allows positive T and U parameters and the T parameter varies in the range 0\sim 1/(25\alpha), the upper bound of T parameter will decrease as long as Z' mass become large. The S parameter can be either positive or negative depending on whether the Z' mass is large or small. The Z' mass is also bounded above and the upper bound depend on value of T parameter. We obtain the values for all the coefficients of the electroweak chiral Lagrangian up to order of p^4.Comment: 52 pages, 15 figure