Synthesis, crystal structure, antioxidation and fluorescence of two lanthanide complexes with a noncyclic polyether Schiff base ligand

<p>Two lanthanide (Sm and La) complexes with the Schiff base ligand bis(3-methoxysalicylidene)-3-oxapentane-1,5-diamine (Bod) have been synthesized and characterized by physico-chemical and spectroscopic methods. [Sm(Bod)(NO₃)₃] {bis(3-methoxysalicylidene)-3-oxapentane-1,5-diamine samarium(III) trinitrate} (<b>1</b>) is a discrete mononuclear species and [La(Bod)(NO₃)₃(DMF)]_n {bis(3-methoxysalicylidene)-3-oxapentane-1,5-diamine dimethylformamide lanthanum(III) trinitrate}_n (<b>2</b>) formed an inorganic coordination polymer. In the two complexes, the metal ions are both ten-coordinate and the geometric structure around the Ln(III) ions can be described as distorted hexadecahedral. An antioxidant assay <i>in vitro</i> shows that complexes <b>1</b> and 2 exhibit better scavenging activity than both the ligand and the usual antioxidants on hydroxyl and superoxide radicals. Under excitation at room temperature, a red shift in the fluorescence band of the ligand in the complexes compared with that of the free ligand can be attributed to coordination of the rare earth ions to the ligand. Furthermore, <b>1</b> produced characteristic Sm(III) luminescence, which indicates the ligand Bod is a good organic chelator to absorb energy and transfer it to the Sm³⁺ ion.</p

Image_1_The alteration of left ventricular strain in later-onset spinal muscular atrophy children.tif

BackgroundPatients with spinal muscular atrophy (SMA) may suffer from multisystem injury, including an impaired cardiovascular system. However, M-mode echocardiography, the current dominant echocardiographic modality, is limited in the detection of myocardial injury. We considered the use of left ventricular strain imaging in detecting myocardial injury and explored the serum lipid profile related to cardiovascular disease in later-onset SMA children.MethodsA case-control study involving 80 patients with later-onset SMA and 80 age-, gender-, and body surface area-matched control children was conducted in a single tertiary pediatric hospital in China. Data on the left ventricular strain measured using two-dimensional speckle tracking echocardiography, left ventricular function parameters assessed by M-mode echocardiography, and serum lipid profile of these two groups were retrospectively collected for differential analysis.ResultsThe mean age of the 80 SMA patients were (6.87 ± 2.87) years, of which 46 were type 2 and 34 were type 3 patients. The global longitudinal strain (GLS) of the SMA group (−18.7 ± 2.9%, p ConclusionCompared with healthy controls, later-onset SMA children presented with reduced GLS and prolonged TTPLS while the LVEF and LVFS values were within normal range. In particular, whether a reduced GLS or prolonged TTPLS in later-onset SMA compared to the control group can predict the risk of future cardiomyopathy remains to be investigated.</p