Impact of classroom design on interactive whiteboard use in a special needs classroom

The physical environment of a classroom—how space is organized and controlled—impacts the use of technology within that setting. This paper presents the initial rationale for choosing an interactive whiteboard (IWB) as the platform for software designed to encourage play in primary students with Autism Spectrum Disorders. An observational study of normal classroom practice and of an installed version of the software uncovered factors in the physical installation of the IWB and its pedagogical use that negatively affect its potential use

From Aspirations to Action: The Role of Middle School Parents in Making the Dream of College a Reality

Looks at the number of parents who have taken steps to prepare for their children's college education by the time their children are in middle school

How to plan a successful TEDx conference at West Virginia University

This research paper and the coinciding booklet offer pertinent information to help one plan and organize a successful TEDx conference at West Virginia University. It describes all of the details and explains factors that are unique to this specific event. The information contained in these documents was gathered from planning the first ever TEDxWVU event, which took place on Friday, March 2, 2018 at the Media Innovation Center on the fourth floor of the Evansdale Crossing building. This first event was scheduled to be an all-day event with nine speakers

Integration of informal music technologies in secondary school music lessons

date-added: 2011-08-12 11:03:06 +0100 date-modified: 2011-08-12 11:03:38 +0100date-added: 2011-08-12 11:03:06 +0100 date-modified: 2011-08-12 11:03:38 +0100This project was supported by EPSRC grant EP/I001832/1, ‘Musicology for the masses’

Connection between conjunctive capacity and structural properties of graphs

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Higher Education in Michigan: Overcoming Challenges to Expand Access

Examines in detail the barriers to higher education in three underserved Michigan communities, and recommends options for improving access at the state level, coordination among institutions, healthcare training, public transportation, and affordability

Wind energy leasing handbook

The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311

Kinetic Investigation of Escherichia coli RNA Polymerase Mutants That Influence Nucleotide Discrimination and Transcription Fidelity

Recent RNA polymerase (RNAP) structures led to a proposed three-step model of nucleoside triphosphate (NTP) binding, discrimination, and incorporation. NTPs are thought to enter through the secondary channel, bind to an E site, rotate into a pre-insertion (PS) site, and ultimately align in the catalytic (A) site. We characterized the kinetics of correct and incorrect incorporation for several Escherichia coli RNAPs with substitutions in the proposed NTP entry pore (secondary channel). Substitutions of the semi-conserved residue betaAsp(675), which is >10A away from these sites, significantly reduce fidelity; however, substitutions of the totally conserved residues betaArg(678) and betaAsp(814) do not significantly alter the correct or incorrect incorporation kinetics, even though the corresponding residues in RNAPII crystal structures appear to be interacting with the NTP phosphate groups and coordinating the second magnesium ion in the active site, respectively. Structural analysis suggests that the lower fidelity of the betaAsp(675) mutants most likely results from reduction of the negative potential of a small pore between the E and PS sites and elimination of several structural interactions around the pore. We suggest a mechanism of nucleotide discrimination that is governed both by rotation of the NTP through this pore and subsequent rearrangement or closure of RNAP to align the NTP in the A site