Magnetization plateau in the spin ladder with the four-spin exchange

The magnetization process of the $S$=1/2 antiferromagnetic spin ladder with the four-spin cyclic exchange interaction at T=0 is studied by the exact diagonalization of finite clusters and size scaling analyses. It is found that a magnetization plateau appears at half the saturation value if the ratio of the four- and two-spin exchange coupling constants $J_4$ is larger than the critical value $J_{4c}=0.05\pm$0.04. The phase transition with respect to $J_4$ at $J_{4c}$ is revealed to be the Kosterlitz-Thouless-type.Comment: 4 pages, Revtex, with 5 eps figure

An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism

The signalling pathways underpinning cell growth and invasion use overlapping components, yet how mutually exclusive cellular responses occur is unclear. Here, we report development of 3-Dimensional culture analyses to separately quantify growth and invasion. We identify that alternate variants of IQSEC1, an ARF GTPase Exchange Factor, act as switches to promote invasion over growth by controlling phosphoinositide metabolism. All IQSEC1 variants activate ARF5- and ARF6-dependent PIP5-kinase to promote PI(3,4,5)P3-AKT signalling and growth. In contrast, select pro-invasive IQSEC1 variants promote PI(3,4,5)P3 production to form invasion-driving protrusions. Inhibition of IQSEC1 attenuates invasion in vitro and metastasis in vivo. Induction of pro-invasive IQSEC1 variants and elevated IQSEC1 expression occurs in a number of tumour types and is associated with higher-grade metastatic cancer, activation of PI(3,4,5)P3 signalling, and predicts long-term poor outcome across multiple cancers. IQSEC1-regulated phosphoinositide metabolism therefore is a switch to induce invasion over growth in response to the same external signal. Targeting IQSEC1 as the central regulator of this switch may represent a therapeutic vulnerability to stop metastasis

Assessment of systemic AAV-microdystrophin gene therapy in the GRMD model of Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease caused by the absence of dystrophin, a membrane-stabilizing protein encoded by the DMD gene. Although mouse models of DMD provide insight into the potential of a corrective therapy, data from genetically homologous large animals, such as the dystrophin-deficient golden retriever muscular dystrophy (GRMD) model, may more readily translate to humans. To evaluate the clinical translatability of an adeno-associated virus serotype 9 vector (AAV9)–microdystrophin (μDys5) construct, we performed a blinded, placebo-controlled study in which 12 GRMD dogs were divided among four dose groups [control, 1 × 1013 vector genomes per kilogram (vg/kg), 1 × 1014 vg/kg, and 2 × 1014 vg/kg; n = 3 each], treated intravenously at 3 months of age with a canine codon-optimized microdystrophin construct, rAAV9-CK8e-c-μDys5, and followed for 90 days after dosing. All dogs received prednisone (1 milligram/kilogram) for a total of 5 weeks from day-7 through day 28. We observed dose-dependent increases in tissue vector genome copy numbers; μDys5 protein in multiple appendicular muscles, the diaphragm, and heart; limb and respiratory muscle functional improvement; and reduction of histopathologic lesions. As expected, given that a truncated dystrophin protein was generated, phenotypic test results and histopathologic lesions did not fully normalize. All administrations were well tolerated, and adverse events were not seen. These data suggest that systemically administered AAV-microdystrophin may be dosed safely and could provide therapeutic benefit for patients with DMD

A study of the evolution of the representational capabilities of process modeling grammars

A plethora of process modeling techniques has been proposed over the years. One way of evaluating and comparing the scope and completeness of techniques is by way of representational analysis. The purpose of this paper is to examine how process modeling techniques have developed over the last four decades. The basis of the comparison is the Bunge-Wand-Weber representation model, a benchmark used for the analysis of grammars that purport to model the real world and the interactions within it. This paper presents a comparison of representational analyses of several popular process modeling techniques and has two main outcomes. First, it provides insights, within the boundaries of a representational analysis, into the extent to which process modeling techniques have developed over time. Second, the findings also indicate areas in which the underlying theory seems to be over-engineered or lacking in specialization

The Durham/UKST Galaxy Redshift Survey - I. Large-scale structure in the Universe

We present the first results from the Durham/UKST Galaxy Redshift Survey and consider their implications on current models of structure formation. This bJ ≤ 17 mag survey contains ∼ 2500 galaxy redshifts sampled at a rate of 1 in 3 from the Edinburgh/Durham Southern Galaxy Catalogue. We find that the galaxy distribution shows evidence of large 'cellular' features on 50-100 h-1 Mpc scales. This clustering has been statistically analysed using the 2-point correlation function, ξ. The results show that the structures in this survey have power significantly in excess of the predictions of the standard cold dark matter (CDM) cosmological model on scales of 15-30 h-1 Mpc, and therefore support the previous observational results from the APM survey. At smaller scales, we measure the one-dimensional pairwise galaxy velocity dispersion in the Durham/UKST survey to be 387-62 +96 km s-1. This is also inconsistent with the prediction of the standard CDM model, assuming linear biasing. Finally, at larger scales, the Durham/UKST survey has produced the most accurate detection yet of large-scale redshift space distortions due to dynamical infall of galaxies. We obtain a best estimate of Ω0.6/b = 0.55 ± 0.12, where Ω is the mean mass density of the Universe and b is the linear bias factor. Depending on the choice of b, this result is consistent either with a low-density universe (b ≃ 1) or a critical-density universe (b ≃ 2).link_to_subscribed_fulltex

The Durham/UKST Galaxy Redshift Survey - V. The catalogue

We present the radial velocities and blue, optical magnitudes for all of the galaxies within the Durham/UKST Galaxy Redshift Survey. This catalogue consists of ∼2500 galaxy redshifts to a limiting apparent magnitude of bJ ≃ 17 mag, covering a ∼1500-deg2 area around the South Galactic Pole. The galaxies in this survey were selected from the Edinburgh/Durham Southern Galaxy Catalogue and were sampled, in order of apparent magnitude, at a rate of one galaxy in every three. The spectroscopy was performed at the 1.2-m UK Schmidt Telescope in Australia using the FLAIR multi-object spectrograph. We show that our radial velocity measurements made with this instrument have an empirical accuracy of ±150 km s-1. The observational techniques and data reduction procedures used in the construction of this survey are also discussed. This survey demonstrates that the UKST can be used to make a three-dimensional map of the large-scale galaxy distribution, via a redshift survey to bJ ≃ 17 mag, over a wide area of the sky.link_to_subscribed_fulltex