A mobile health app for the collection of functional outcomes after inpatient stroke rehabilitation: Pilot randomized controlled trial

BACKGROUND: Monitoring the functional status of poststroke patients after they transition home is significant for rehabilitation. Mobile health (mHealth) technologies may provide an opportunity to reach and follow patients post discharge. However, the feasibility and validity of functional assessments administered by mHealth technologies are unknown. OBJECTIVE: This study aimed to evaluate the feasibility, validity, and reliability of functional assessments administered through the videoconference function of a mobile phone-based app compared with administration through the telephone function in poststroke patients after rehabilitation hospitalization. METHODS: A randomized controlled trial was conducted in a rehabilitation hospital in Southeast China. Participants were randomly assigned to either a videoconference follow-up (n=60) or a telephone follow-up (n=60) group. We measured the functional status of participants in each group at 2-week and 3-month follow-up periods. Half the participants in each group were followed by face-to-face home visit assessments as the gold standard. Validity was assessed by comparing any score differences between videoconference follow-up and home visit assessments, as well as telephone follow-up and home visit assessments. Reliability was assessed by computing agreements between videoconference follow-up and home visit assessments, as well as telephone follow-up and home visit assessments. Feasibility was evaluated by the levels of completion, satisfaction, comfort, and confidence in the 2 groups. RESULTS: Scores obtained from the videoconference follow-up were similar to those of the home visit assessment. However, most scores collected from telephone administration were higher than those of the home visit assessment. The agreement between videoconference follow-up and home visit assessments was higher than that between telephone follow-up and home visit assessments at all follow-up periods. In the telephone follow-up group, completion rates were 95% and 82% at 2-week and 3-month follow-up points, respectively. In the videoconference follow-up group, completion rates were 95% and 80% at 2-week and 3-month follow-up points, respectively. There were no differences in the completion rates between the 2 groups at all follow-up periods (X CONCLUSIONS: The videoconference follow-up assessment of functional status demonstrates higher validity and reliability, as well as higher confidence and satisfaction perceived by patients, than the telephone assessment. The videoconference assessment provides an efficient means of assessing functional outcomes of patients after hospital discharge. This method provides a novel solution for clinical trials requiring longitudinal assessments. TRIAL REGISTRATION: chictr.org.cn: ChiCTR1900027626; http://www.chictr.org.cn/edit.aspx?pid=44831&htm=4

Hydraulic Conductivity Characteristics of Desert Plant Organs: Coping with Drought Tolerance Strategy

Plant hydraulic conductivity (K) refers to the rate of water flow (kg s−1) per unit pressure drop (MPa), which drives flow through the plant organ system. It is an important eco-physiology index for measuring plant water absorption and transport capacity. A field study was conducted in the arid region of the Heihe River Basin in northwestern China, plant hydraulic conductivity was measured by high-pressure flowmeter (HPFM) to investigate the characteristics of hydraulic conductivity of typical dominant desert plants (Reaumuria soongarica M., Nitraria sphaerocarpa M., and Sympegma regelii B.) and their relationship with functional traits of leaves, stems, and roots, and explaining their adaptation strategies to desert environment from the perspective of plant organs hydraulic conductivity. The results showed that the hydraulic conductivity of the leaves and stems of R. soongarica and N. sphaerocarpa (KLA, leaf hydraulic conductivity per unit leaf area; KLW, leaf hydraulic conductivity per unit leaf weight; KSLA, stem hydraulic conductivity per unit leaf area; KSLW, stem hydraulic conductivity per unit leaf weight) were significantly lower than those of S. regelii, while their fine root (KRL, root hydraulic conductivity per unit leaf length; KRSA, root hydraulic conductivity per unit root surface area) and whole root (KTRW, whole root hydraulic conductivity per unit root weight) of hydraulic conductivity were significantly higher than those of S. regelii. In addition, KLA and KLW, KSLA and KSLW, and KRL and KRSA in three desert plants all exhibited consistent trends. Correlation analysis illustrated that the hydraulic conductivity of leaves and stems had a significantly positive correlation, but they had no significant negative correlation with the specific leaf weight (SLW, specific leaf weight). The hydraulic conductivity of fine root weight (KRW, root hydraulic conductivity per unit root weight) and specific root surface area (SRSA, specific root surface area) showed significantly positive correlation (r = 0.727, P < 0.05). The results demonstrated that the R. soongarica and N. sphaerocarpa preserved their water content through the strong leaf absorption capacity of soil water and the low water dispersion rates of leaves to adapt to the harsher arid habitat, which is more drought tolerant than S. regelii

Dietary shift and social hierarchy from the Proto-Shang to Zhou Dynasty in the Central Plains of China

The Proto-Shang, the Shang and the Zhou dynasties (∼2000–221 BCE: Before Common Era) are key periods in the origin and evolution of ancient civilizations in China since the periods include the processes and mechanisms of social development in the Central Plains of China during the Bronze Age. However, human-environment interactions in the context of trans-Eurasia cultural exchange during that time are not well-understood. In this study, isotopic analysis and radiocarbon dating of human and animal bones from Xinancheng cemetery in southeast Shanxi Province are reported. It was deduced that, for the period ∼1000–800 BCE, humans buried in Xinancheng cemetery relied primarily on C _4 -based foods and upper-status individuals consumed more animal protein and probably C _3 crops. Also, considering the paleoclimate and other archaeological data of the Central Plains, the human diet and subsistence strategies changed significantly with more C _3 staples such as wheat being consumed during the Eastern Zhou (770–221 BCE), as evidenced by an increased intake of wheat by lower-status individuals and the development of a mixed wheat and millet agricultural system. It is argued that the socio-economic change around the late western Zhou-early eastern Zhou Dynasty occurred as a result of the necessity to adapt to the aggravation caused by climate deterioration and population pressures, factors which profoundly influenced the economic and lifestyle patterns in ancient China. The socio-economic system of the Eastern Zhou Dynasty displayed more resilience to climate change than that of earlier periods

Trade-Off Relationships of Leaf Functional Traits of Lycium ruthenicum in Response to Soil Properties in the Lower Reaches of Heihe River, Northwest China

Soil properties affect plant growth and cause variation in leaf functional traits. Lycium ruthenicum Murray is one of the desert dominant shrubs and halophytes in the lower reaches of Heihe River, Northwest China. We analyzed the trade-off relationships of 14 leaf functional traits of eight L. ruthenicum populations growing at varying distances from the river and discussed the effects that soil properties have on leaf functional traits. The results showed that: Lower leaf nitrogen (N) content indicated that L.ruthenicum was located at the slow investment–return axis of the species resource utilization graph. Compared with non-saline and very slightly saline habitats, populations of slightly saline habitats showed a higher carbon to nitrogen ratio (C:N). Redundancy analysis (RDA) revealed a relatively strong relationship between leaf functional traits and soil properties, the first RDA axis accounted for 70.99 and 71.09% of the variation in 0–40 and 40–80 cm of soil properties. Relative importance analysis found that in the 0–40 cm soil layer, leaf traits variations were mainly influenced by soil moisture (SWC), HCO3− and CO32− ions content, while leaf traits variations in the 40–80 cm soil layer were mainly influenced by HCO3− and SO42−. L.ruthenicum has a foliar resource acquisition method and a resource conservation trade-off with a flexible life history strategy in habitats with drought and salinity stress. In the shallow soil layers, water affects leaf traits variation greater than salt, and in both shallow and deep soil layers, HCO3− plays a dominant role on leaf traits. This study provides insights into the adversity adaptation strategies of desert plants and the conservation and restoration of arid-saline ecosystems

Trade-off between leaf turnover and biochemical responses related to drought tolerance in desert woody plants

We describe differences in leaf photo-protection mechanisms in a group of arid adapted C3 and C4 shrubs that differ in their leaf life-span and compared these mechanisms to known differences in drought tolerance. The experiments were carried out in the field with fourteen woody species native to the Hexi Corridor region, northwestern China. We assessed water status, chlorophyll content, antioxidant enzymes activity, and solute content. We found that differences in photo-protection mechanism among species were not a consequence of differences in photosynthetic pathway, but they were related to leaf life-span. Further, we found evidence that supports the concept of a trade-off between leaf turnover and photo-protective mechanism: species with a longer leaf life-span (leaves with low turnover rate) had higher values of enzymatic (POD and CAT) and no-enzymatic (Chl a, Chl b, Car, and soluble sugars-SS) compounds, than species with a shorter life-span (high turnover rate). These different photoprotective strategies are in accordance with known differences in morphological and physiological leaf attributes that allow for rapid acquisition resources (i.e. acquisitive type) or permit conservation of resources within well protected tissues (i.e. conservative type).Fil: Zhou, Zijuan. Chinese Academy Of Sciences; ChinaFil: Su, Peixi. Chinese Academy Of Sciences; ChinaFil: Xie, Tingting. Chinese Academy Of Sciences; ChinaFil: Li, Shanjia. Chinese Academy Of Sciences; ChinaFil: Zhang, Haina. Chinese Academy Of Sciences; ChinaFil: Gonzalez Paleo, Luciana. Museo Paleontológico Egidio Feruglio; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Synthesis, in vitro antitumor evaluation and structure activity relationship of heptacoordinated amino-bis(Phenolato) Ti(IV) complexes stabilized by 2,6-dipicolinic acid

Eighteen novel Ti(IV) complexes stabilized by different chelating amino-bis(phenolato) (ONNO, ONON, ONOO) ligands and 2,6-dipicolinic acid as a second chelator were synthesized with isolated yields ranging from 79 to 93%. Complexes were characterized by 1H and 13C-NMR spectroscopy, as well as by HRMS and X-Ray diffraction analysis. The good to excellent aqueous stability of these Ti(IV) complexes can be modulated by the substitutions on the 2-position of the phenolato ligands. Most of the synthesized Ti(IV) complexes demonstrated potent inhibitory activity against Hela S3 and Hep G2 tumor cells. Among them, the naphthalenyl based Salan type 2j, 2-picolylamine based [ONON] type 2n and N-(2-hydroxyethyl) based [ONOO] type 2p demonstrated up to 40 folds enhanced cytotoxicity compared to cisplatin together with a significantly reduced activity against healthy AML12 cells. The three Ti(IV) complexes exhibited fast cellular uptake by Hela S3 cells and induced almost exclusively apoptosis. 2j could trigger higher level of ROS generation than 2p and 2n.publishe

Leaf functional traits of dominant desert plants in the Hexi Corridor, Northwestern China: Trade-off relationships and adversity strategies

Desert plants are zonal vegetation with unique functional traits and resource trade-offs in arid areas. The trade-off relationship among functional traits and adversity strategies of desert plants play a key role in their community construction. We investigated 16 leaf functional traits of the dominant desert plants, including15 shrubs and 11 herbs, in the Hexi Corridor from southeast to northwest, and analyzed the variation characteristics of traits, trade-off relationship among traits and their responses to soil properties at the regional scale. The results showed that bound water (BW), leaf thickness (LT), and carbon phosphorus ratio (C:P) but total water content (TWC), free water (FW), specific leaf volume (SLV), and specific leaf area (SLA) under shrubs were significantly higher and significantly lower than under herbs, respectively; shrubs’ leaf traits BW and FW ratio (BW:FW), phosphorus content (P), C:P, nitrogen and phosphorus ratio (N:P) had great coefficient of variation, while herbs’ leaf traits BW and N:P had great coefficient of variation. Trade-off among the measured traits was diverse. The TWC, BW, SLV, leaf succulence (Suc), SLA, leaf dry matter content (LDMC) and LT are prominent traits that represent and reflect desert plants under adversity stress. Soil organic carbon (SOC), elevation, pH, soil water content (SW) and sand (0.5-0.25 mm) are important factors influencing the changes of shrubs’ leaf traits, while available phosphorus (AP), SOC, silt (0.02-0.002 mm), sand (0.10-0.05 mm) and clay (<0.002 mm) are dominant factors affecting the changes of herbs’ leaf traits. The results from the present study can provide theoretical support for the maintenance, management and stability of the Hexi Corridor’ ecosystems

Asynchronous Transformation of Cropping Patterns from 5800–2200 cal BP on the Southern Loess Plateau, China

Archaeobotanical studies have largely illuminated spatiotemporal differences in agricultural development across the Loess Plateau. However, the particularities of local agricultural development have not been adequately studied for complex geographical, environmental, and prehistoric contexts. Here, new archaeobotanical data and radiocarbon dating results from 27 Neolithic and Bronze Age sites in Baoji are reported. Combining these data with published archaeobotanical datasets, this study explores shifts (and underlying driving factors) in cropping patterns from the late Neolithic to Bronze Age on the southern Loess Plateau (SLP). Regional geographic, environmental, and climatic factors produced mixed millet-rice agricultural systems in the Guanzhong Plain (GZP) and western Henan Province (WHN) and foxtail and broomcorn millet dry-farming systems in the Upper Weihe River (UWR) from 5800–4500 cal BP. Wheat and barley were added to the agricultural systems of the UWR as auxiliary crops after ~4000 cal BP, while cropping patterns remained largely unchanged in GZP and WHN from 4500–3500 cal BP. Cultural exchanges and technological innovations may have influenced the formation of different agricultural patterns across the three regions (i.e., GZP, WHN, and UWR) from 4500–3500 cal BP. From 3500–2200 cal BP, wheat and barley became increasingly important crops on the SLP, although their importance varied spatially, and rice was rarely cultivated. Spatiotemporal variation in cropping patterns was driven by altered survival pressures associated with climate deterioration and population growth from 3500–2200 cal BP. This process was reinforced by internal social developments, as well as interactions with close northern neighbors, in the Shang-Zhou period

Asynchronous Transformation of Cropping Patterns from 5800&ndash;2200 cal BP on the Southern Loess Plateau, China

Archaeobotanical studies have largely illuminated spatiotemporal differences in agricultural development across the Loess Plateau. However, the particularities of local agricultural development have not been adequately studied for complex geographical, environmental, and prehistoric contexts. Here, new archaeobotanical data and radiocarbon dating results from 27 Neolithic and Bronze Age sites in Baoji are reported. Combining these data with published archaeobotanical datasets, this study explores shifts (and underlying driving factors) in cropping patterns from the late Neolithic to Bronze Age on the southern Loess Plateau (SLP). Regional geographic, environmental, and climatic factors produced mixed millet-rice agricultural systems in the Guanzhong Plain (GZP) and western Henan Province (WHN) and foxtail and broomcorn millet dry-farming systems in the Upper Weihe River (UWR) from 5800&ndash;4500 cal BP. Wheat and barley were added to the agricultural systems of the UWR as auxiliary crops after ~4000 cal BP, while cropping patterns remained largely unchanged in GZP and WHN from 4500&ndash;3500 cal BP. Cultural exchanges and technological innovations may have influenced the formation of different agricultural patterns across the three regions (i.e., GZP, WHN, and UWR) from 4500&ndash;3500 cal BP. From 3500&ndash;2200 cal BP, wheat and barley became increasingly important crops on the SLP, although their importance varied spatially, and rice was rarely cultivated. Spatiotemporal variation in cropping patterns was driven by altered survival pressures associated with climate deterioration and population growth from 3500&ndash;2200 cal BP. This process was reinforced by internal social developments, as well as interactions with close northern neighbors, in the Shang-Zhou period

Synthesis and X-ray structure analysis of cytotoxic heptacoordinated Salan hafnium^(IV) complexes stabilized with 2,6-dipicolinic acid

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