Polimorfizm rs10830963 w genie receptora melatoniny 1B a cukrzyca ciążowa w populacji chińskiej — metaanaliza badań

Introduction: Studies have been conducted to investigate the association between rs10830963 of MTNR1B and the risk of gestational diabetes mellitus (GDM), but with inconclusive results. We aimed to clarify these controversies, especially with regard to the association in the Chinese population. Material and methods: A systemic literature reference search inclusive to August 12, 2016 yielded 35 articles, from which 11 studies met the inclusion criteria for the final meta-analysis, including 3889 patients with GDM and 6708 controls. Results: We found statistically significant associations between rs10830963 and GDM using odds ratios (ORs) and 95% confidence intervals (CIs) [GG genotype vs. CC genotype: OR = 1.70, 95% CI: 1.38–2.10; G allele vs C allele: OR = 1.27, 95% CI: 1.20–1.36; GG+CG vs. CC (dominant model): OR = 1.31, 95% CI: 1.20–1.44; GG vs CG+CC (recessive model): OR = 1.41, 95% CI: 1.26–1.58]. In subgroup analyses stratified by ethnicity, we also observed rs10830963 to be associated with significantly increased risk of GDM in all genetic models in the Chinese population. Conclusions: Our meta-analysis indicated that the rs10830963 polymorphism might serve as a risk factor of GDM in the Chinese population.Wstęp: Wyniki dotychczas badań przeprowadzonych w celu ustalenia związku między polimorfizmem rs10830963 w genie MTNR1B a ryzykiem cukrzycy ciążowej (gestational diabetes mellitus, GDM) nie pozwoliły na sformułowanie jednoznacznych wniosków. Niniejsze badanie przeprowadzono w celu wyjaśnienia tych kontrowersji, zwłaszcza w odniesieniu do występowania tych związków w populacji chińskiej. Materiał i metody: W wyniku przeszukania w sposób systematyczny piśmiennictwa obejmującego okres do 12 sierpnia 2016 roku wytypowano 35 artykułów, spośród których 11 badań spełniało kryteria włączenia do metaanalizy. Obejmowały one 3889 chorych z GDM i 6708 osób kontrolnych. Wyniki: Autorzy stwierdzili statystycznie istotny związek między polimorfizmem rs10830963 a GDM, obliczając ilorazy szans (odds ratio, OR) i 95-procentowe przedziały ufności (confidence interval, CI) [genotyp GG vs. genotyp CC: OR = 1,70; 95% CI: 1,38–2,10; allel G vs. allel C: OR = 1,27; 95% CI: 1,20–1,36; GG+CG vs CC (model dominujący): OR = 1,31; 95% CI: 1,20–1,44; GG vs. CG+CC (model recesywny): OR = 1,41; 95% CI: 1,26–1,58]. W analizach podgrup wydzielonych na podstawie pochodzenia etnicznego również stwierdzono, że polimorfizm rs10830963 wiąże się z istotnie wyższym ryzykiem GDM we wszystkich modelach genetycznych w populacji chińskiej. Wnioski: Przeprowadzona przez autorów metaanaliza wskazuje, że polimorfizm rs10830963 może być uważany za czynnik ryzyka GDM w populacji chińskiej

Improved measurements of the Dalitz decays η/η′→γe+e−\eta/\eta'\rightarrow\gamma e^{+}e^{-}

Based on a data sample of 10 billion $J/\psi$ events collected with the BESIII detector, improved measurements of the Dalitz decays $\eta/\eta'\rightarrow\gamma e^+e^-$ are performed, where the $\eta$ and $\eta'$ are produced through the radiative decays $J/\psi\rightarrow\gamma \eta/\eta'$. The branching fractions of $\eta\rightarrow\gamma e^+e^-$ and $\eta'\rightarrow\gamma e^+e^-$ are measured to be $(7.07 \pm 0.05 \pm 0.23)\times10^{-3}$ and $(4.83\pm0.07\pm0.14)\times10^{-4}$, respectively. Within the single pole model, the parameter of electromagnetic transition form factor for $\eta\rightarrow\gamma e^+e^-$ is determined to be $\Lambda_{\eta}=(0.749 \pm 0.027 \pm 0.007)~ {\rm GeV}/c^{2}$. Within the multi-pole model, we extract the electromagnetic transition form factors for $\eta'\rightarrow\gamma e^+e^-$ to be $\Lambda_{\eta'} = (0.802 \pm 0.007\pm 0.008)~ {\rm GeV}/c^{2}$ and $\gamma_{\eta'} = (0.113\pm0.010\pm0.002)~ {\rm GeV}/c^{2}$. The results are consistent with both theoretical predictions and previous measurements. The characteristic sizes of the interaction regions for the $\eta$ and $\eta'$ are calculated to be $(0.645 \pm 0.023 \pm 0.007 )~ {\rm fm}$ and $(0.596 \pm 0.005 \pm 0.006)~ {\rm fm}$, respectively. In addition, we search for the dark photon in $\eta/\eta^\prime\rightarrow\gamma e^{+}e^{-}$, and the upper limits of the branching fractions as a function of the dark photon are given at 90\% confidence level

First Measurement of the Decay Asymmetry in the pure W-boson-exchange Decay Λc+→Ξ0K+\Lambda_{c}^{+}\to\Xi^{0}K^{+}

Based on $4.4~\text{fb}^{-1}$ of $e^{+}e^{-}$ annihilation data collected at the center-of-mass energies between $4.60$ and $4.70~\text{GeV}$ with the BESIII detector at the BEPCII collider, the pure \textit{W}-boson-exchange decay $\Lambda_{c}^{+}\to\Xi^{0}K^{+}$ is studied with a full angular analysis. The corresponding decay asymmetry is measured for the first time to be $\alpha_{\Xi^{0}K^{+}}=0.01\pm0.16({\rm stat.})\pm0.03({\rm syst.})$. This result reflects the non-interference effect between the $S$- and $P$-wave amplitudes. The phase shift between $S$- and $P$-wave amplitudes has two solutions, which are $\delta_{p}-\delta_{s}=-1.55\pm0.25({\rm stat.})\pm0.05({\rm syst.})~\text{rad}$ or $1.59\pm0.25({\rm stat.})\pm0.05({\rm syst.})~\text{rad}$

Measurement of the Electromagnetic Transition Form-factors in the decays η′→π+π−l+l−\eta'\rightarrow\pi^+\pi^-l^+l^-

With a sample of $(10087\pm44)\times10^{6}$ $J/\psi$ events accumulated with the BESIII detector, we analyze the decays $\eta'\rightarrow\pi^+\pi^-l^+l^-(l=e,$ $\mu)$ via the process $J/\psi\rightarrow\gamma\eta'$. The branching fractions are measured to be $\mathcal{B}(\eta'\rightarrow\pi^+\pi^-e^+e^-)=(2.45\pm0.02(\rm{stat.})\pm0.08(\rm{syst.})) \times10^{-3}$ and $\mathcal{B}(\eta'\rightarrow\pi^+\pi^-\mu^+\mu^-)=(2.16\pm0.12(\rm{stat.})\pm0.06(\rm{syst.}))\times10^{-5}$, and the ratio is $\frac{\mathcal{B}(\eta'\rightarrow\pi^{+}\pi^{-}e^{+}e^{-})}{\mathcal{B}(\eta'\rightarrow\pi^{+}\pi^{-}\mu^{+}\mu^{-})} = 113.4\pm0.9(\rm{stat.})\pm3.7(\rm{syst.})$. In addition, by combining the $\eta'\rightarrow\pi^+\pi^-e^+e^-$ and $\eta'\rightarrow\pi^+\pi^-\mu^+\mu^-$ decays, the slope parameter of the electromagnetic transition form factor is measured to be $b_{\eta'}=1.30\pm0.19\ (\mathrm{GeV}/c^{2})^{-2}$, which is consistent with previous measurements from BESIII and theoretical predictions from the VMD model. The asymmetry in the angle between the $\pi^+\pi^-$ and $l^+l^-$ decay planes, which has the potential to reveal the $CP$-violation originating from an unconventional electric dipole transition, is also investigated. The asymmetry parameters are determined to be $\mathcal{A}_{CP}(\eta'\rightarrow\pi^+\pi^-e^+e^-)=(-0.21\pm0.73(\rm{stat.})\pm0.01(\rm{syst.}))\%$ and $\mathcal{A}_{CP}(\eta'\rightarrow\pi^+\pi^-\mu^+\mu^-)=(0.62\pm4.71(\rm{stat.})\pm0.08(\rm{syst.}))\%$, implying that no evidence of $CP$-violation is observed at the present statistics. Finally, an axion-like particle is searched for via the decay $\eta'\rightarrow\pi^+\pi^-a, a\rightarrow e^+e^-$, and upper limits of the branching fractions are presented for the mass assumptions of the axion-like particle in the range of $0-500\ \mathrm{MeV}/c^{2}$

Amplitude Analysis of the Decays D0→π+π−π+π−D^0\to\pi^+\pi^-\pi^+\pi^- and π+π−π0π0\pi^+\pi^-\pi^0\pi^0

Using $e^+e^-$ annihilation data corresponding to an integrated luminosity of 2.93 $\rm fb^{-1}$ taken at the center-of-mass energy $\sqrt{s}=3.773$~GeV with the BESIII detector, a joint amplitude analysis is performed on the decays $D^0\to\pi^+\pi^-\pi^+\pi^-$ and $D^0\to\pi^+\pi^-\pi^0\pi^0$(non-$\eta$). The fit fractions of individual components are obtained, and large interferences among the dominant components of $D^{0}\to a_{1}(1260)\pi$, $D^{0}\to\pi(1300)\pi$, $D^{0}\to\rho(770)\rho(770)$ and $D^{0}\to2(\pi\pi)_{S}$ are found in both channels. With the obtained amplitude model, the $CP$-even fractions of $D^0\to \pi^+\pi^-\pi^+\pi^-$ and $D^0\to\pi^+\pi^-\pi^0\pi^0$(non-$\eta$) are determined to be $(75.2\pm1.1_{\rm stat.}\pm1.5_{\rm syst.})\%$ and $(68.9\pm1.5_{\rm stat.}\pm 2.4_{\rm syst.})\%$, respectively. The branching fractions of $D^0\to \pi^+\pi^-\pi^+\pi^-$ and $D^0\to\pi^+\pi^-\pi^0\pi^0$(non-$\eta$) are measured to be $(0.688\pm0.010_{\rm stat.}\pm 0.010_{\rm syst.})\%$ and $(0.951\pm0.025_{\rm stat.}\pm 0.021_{\rm syst.})\%$, respectively. The amplitude analysis provides an important model for binning strategy in the measurements of the strong phase parameters of $D^0 \to 4\pi$ when used to determine the CKM angle $\gamma (\phi_{3})$ via the $B^{-}\to D K^{-}$ decay

First Observation of a Three-Resonance Structure in e+e−→e^+e^-\rightarrow{non-open} Charm Hadrons

We report the measurement of the cross sections for $e^+e^-$$\rightarrow${nOCH} (nOCH stands for non-open charm hadrons) with improved precision at center-of-mass energies from 3.645 to 3.871 GeV. We observe for the first time a three-resonance structure in the energy-dependent lineshape of the cross sections, which are $\mathcal R(3760)$, $\mathcal R(3780)$ and $\mathcal R(3810)$ with significances of $9.4\sigma$, $15.7\sigma$, and $9.8\sigma$, respectively. The $\mathcal R(3810)$ is observed for the first time. We found two solutions in analysis of the cross sections. For solution I [solution II], we measure the mass, the total width and the product of electronic width and nOCH decay branching fraction to be $(3805.8 \pm 1.1 \pm 2.7)$ [$(3805.8 \pm 1.1 \pm 2.7)$] MeV/$c^2$, $(11.6 \pm 2.6 \pm 1.9)$ [$(11.5 \pm 2.5 \pm 1.8)$] MeV, and $(10.8\pm 3.2\pm 2.3)$ [$(11.0\pm 2.9\pm 2.4)$] eV for the $\mathcal R(3810)$, respectively. In addition, we measure the branching fractions ${\mathcal B}({\mathcal R}(3760)$$\rightarrow${nOCH}$)=(24.5 \pm 13.4 \pm 27.4)\% [(6.8 \pm 5.4 \pm 7.6)\%]$ for the first time, and ${\mathcal B}(\mathcal R(3780)$$\rightarrow${nOCH}$)=(11.6 \pm 5.8 \pm 7.8)\% [(10.3 \pm 4.5 \pm 6.9)\%]$. Moreover, we determine the open-charm (OC) branching fraction ${\mathcal B}({\mathcal R}$$(3760)\rightarrow${OC}$)=(75.5 \pm 13.4 \pm 27.4)\% [(93.2 \pm 5.4 \pm 7.6)\%]$, which supports the interpretation of $\mathcal R(3760)$ as an OC pair molecular state, but contained a simple four-quark state component. The first uncertainties are from fits to the cross sections, and the second are systematic

Study of the doubly Cabibbo-suppressed decays Ds+→K+K+π−D^+_s\to K^+K^+\pi^- and Ds+→K+K+π−π0D^+_s\to K^+K^+\pi^-\pi^0

Based on 7.33 fb$^{-1}$ of $e^+e^-$ collision data collected at center-of-mass energies between 4.128 and 4.226 GeV with the BESIII detector, the experimental studies of the doubly Cabibbo-suppressed decays $D^+_s\to K^+K^+\pi^-$ and $D^+_s\to K^+K^+\pi^-\pi^0$ are reported. We determine the absolute branching fraction of $D^+_s\to K^+K^+\pi^-$ to be (${1.23^{+0.28}_{-0.25}}({\rm stat})\pm0.06({\rm syst})$) $\times 10^{-4}$. No significant signal of $D^+_s\to K^+K^+\pi^-\pi^0$ is observed and the upper limit on its decay branching fraction at 90\% confidence level is set to be $1.7\times10^{-4}$.Comment: 10 pages, 4 figures, 4 table

Search for an invisible muon philic scalar X0X_{0} or vector X1X_{1} via J/ψ→μ+μ−+invisibleJ/\psi\to\mu^+\mu^-+\rm{invisible} decay at BESIII

A light scalar $X_{0}$ or vector $X_{1}$ particles have been introduced as a possible explanation for the $(g-2)_{\mu}$ anomaly and dark matter phenomena. Using $(8.998\pm 0.039)\times10^9$ \jpsi events collected by the BESIII detector, we search for a light muon philic scalar $X_{0}$ or vector $X_{1}$ in the processes $J/\psi\to\mu^+\mu^- X_{0,1}$ with $X_{0,1}$ invisible decays. No obvious signal is found, and the upper limits on the coupling $g_{0,1}'$ between the muon and the $X_{0,1}$ particles are set to be between $1.1\times10^{-3}$ and $1.0\times10^{-2}$ for the $X_{0,1}$ mass in the range of $1<M(X_{0,1})<1000$~MeV$/c^2$ at 90$\%$ confidence level.Comment: 9 pages 7 figure

Study of the decay J/ψ→ϕπ0ηJ/\psi \to \phi \pi^{0}\eta

Based on $(10.09 \pm 0.04) \times 10^9$ $J/\psi$ events collected with the BESIII detector operating at the BEPCII collider, a partial wave analysis of the decay $J/\psi \to \phi \pi^{0}\eta$ is performed. We observe for the first time two new structures on the $\phi\eta$ invariant mass distribution, with statistical significances of $24.0\sigma$ and $16.9\sigma$; the first with $J^{\rm PC}$ = $1^{+-}$, mass M = (1911 $\pm$ 6 (stat.) $\pm$ 14 (sys.))~MeV/$c^{2}$, and width $\Gamma =$ (149 $\pm$ 12 (stat.) $\pm$ 23 (sys.))~MeV, the second with $J^{\rm PC}$ = $1^{--}$, mass M = (1996 $\pm$ 11 (stat.) $\pm$ 30 (sys.))~MeV/$c^{2}$, and width $\Gamma$ = (148 $\pm$ 16 (stat.) $\pm$ 66 (sys.))~MeV. These measurements provide important input for the strangeonium spectrum. In addition, the $f_0(980)-a_0(980)^0$ mixing signal in $J/\psi \to \phi f_0(980) \to \phi a_0(980)^0$ and the corresponding electromagnetic decay $J/\psi \to \phi a_0(980)^0$ are measured with improved precision, providing crucial information to understand the nature of $a_0(980)^0$ and $f_0(980)$

Observation of the Y(4230)Y(4230) and evidence for a new vector charmonium-like state Y(4710)Y(4710) in e+e−→KS0KS0J/ψe^{+}e^{-}\to K_{S}^{0} K_{S}^{0} J/\psi

Cross sections for the process $e^{+} e^{-} \to K_{S}^{0} K_{S}^{0} J/\psi$ at center-of-mass energies from $4.128$ to $4.950$ GeV are measured using data samples with a total integrated luminosity of 21.2 fb$^{-1}$ collected by the BESIII detector operating at the BEPCII storage ring. The $Y(4230)$ state is observed in the energy dependence of the $e^{+} e^{-} \to K_{S}^{0} K_{S}^{0} J/\psi$ cross section for the first time with a statistical significance of 26.0$\sigma$. In addition, an enhancement around $4.710$ GeV, called the $Y(4710)$, is seen with a statistical significance of 4.2$\sigma$. There is no clear structure around $4.484$ GeV. Using a fit with a coherent sum of three Breit-Wigner functions, we determine the mass and width of the $Y(4230)$ state to be $4226.9 \pm 6.6 \pm 21.9$ MeV/$c^{2}$ and $71.7 \pm 16.2 \pm 31.4$ MeV, respectively, and the mass and width of the $Y(4710)$ state to be $4704.0 \pm 52.3 \pm 69.5$ MeV/$c^{2}$ and $183.2 \pm 114.0 \pm 90.8$ MeV, respectively, where the first uncertainties are statistical and the second are systematic. In addition, the average Born cross section ratio of $e^{+} e^{-} \to K_{S}^{0} K_{S}^{0} J/\psi$ to $e^{+} e^{-} \to K^{+} K^{-} J/\psi$ is measured to be $0.388_{-0.028}^{+0.035}\pm0.016$, or $0.426_{-0.031}^{+0.038}\pm0.018$ if three-body phase space is considered.Comment: Update draft based the comments from PRD refere