70 research outputs found
Base Erosion and Profit Shifting Exploration of Tax Differences and Tax Economics
- Author
- Publication venue
- 'Scholink Co, Ltd.'
- Publication date
- 17/10/2019
- Field of study
Multinational companies transfer profits to countries with low tax rates via tax planning. In response to the request from G20 nations, the OECD launched a total of 15 BEPS (Base Erosion and Profit Shifting) actions, hoping to prompt the reform in tax systems in different countries. This paper conducts a case study in the examination of taxation differences created by multinational companies by leveraging various tax rates in different countries. Expert interviews are conducted to examine the adjustments and responses of tax planning and investment structures in the corporate world in the wake of the amendments to CFC and PEM tax codes, as well as the correlation between tax revenues and economies. Finally, this paper presents suggestions so that taxes and profits are operated in a fair and efficient environment. This will benefit economic developments and promote effective resources utilization
Aberrant Sensory Gating of the Primary Somatosensory Cortex Contributes to the Motor Circuit Dysfunction in Paroxysmal Kinesigenic Dyskinesia
- Author
- Chien-Chen Chou
- Chien-Chen Chou
- Der-Jen Yen
- Der-Jen Yen
- Fu-Jung Hsiao
- Fu-Jung Hsiao
- Hsiang-Yu Yu
- Hsiang-Yu Yu
- Kang-Yang Jih
- Kang-Yang Jih
- Kwong-Kum Liao
- Kwong-Kum Liao
- Po-Shan Wang
- Po-Shan Wang
- Po-Shan Wang
- Po-Shan Wang
- Rou-Shayn Chen
- Rou-Shayn Chen
- Shang-Yeong Kwan
- Shang-Yeong Kwan
- Shu-Fen Lu
- Wei-Ta Chen
- Wei-Ta Chen
- Wei-Ta Chen
- Wei-Ta Chen
- Yi-Chieh Chen
- Yi-Chieh Chen
- Yo-Tsen Liu
- Yo-Tsen Liu
- Yo-Tsen Liu
- Yo-Tsen Liu
- Yu-Te Wu
- Yu-Te Wu
- Yu-Te Wu
- Yung-Yang Lin
- Yung-Yang Lin
- Yung-Yang Lin
- Yung-Yang Lin
- Yung-Yang Lin
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/10/2018
- Field of study
Paroxysmal kinesigenic dyskinesia (PKD) is conventionally regarded as a movement disorder (MD) and characterized by episodic hyperkinesia by sudden movements. However, patients of PKD often have sensory aura and respond excellently to antiepileptic agents. PRRT2 mutations, the most common genetic etiology of PKD, could cause epilepsy syndromes as well. Standing in the twilight zone between MDs and epilepsy, the pathogenesis of PKD is unclear. Gamma oscillations arise from the inhibitory interneurons which are crucial in the thalamocortical circuits. The role of synchronized gamma oscillations in sensory gating is an important mechanism of automatic cortical inhibition. The patterns of gamma oscillations have been used to characterize neurophysiological features of many neurological diseases, including epilepsy and MDs. This study was aimed to investigate the features of gamma synchronizations in PKD. In the paired-pulse electrical-stimulation task, we recorded the magnetoencephalographic data with distributed source modeling and time-frequency analysis in 19 patients of newly-diagnosed PKD without receiving pharmacotherapy and 18 healthy controls. In combination with the magnetic resonance imaging, the source of gamma oscillations was localized in the primary somatosensory cortex. Somatosensory evoked fields of PKD patients had a reduced peak frequency (p < 0.001 for the first and the second response) and a prolonged peak latency (the first response p = 0.02, the second response p = 0.002), indicating the synchronization of gamma oscillation is significantly attenuated. The power ratio between two responses was much higher in the PKD group (p = 0.013), indicating the incompetence of activity suppression. Aberrant gamma synchronizations revealed the defective sensory gating of the somatosensory area contributes the pathogenesis of PKD. Our findings documented disinhibited cortical function is a pathomechanism common to PKD and epilepsy, thus rationalized the clinical overlaps of these two diseases and the therapeutic effect of antiepileptic agents for PKD. There is a greater reduction of the peak gamma frequency in PRRT2-related PKD than the non-PRRT PKD group (p = 0.028 for the first response, p = 0.004 for the second response). Loss-of-function PRRT2 mutations could lead to synaptic dysfunction. The disinhibiton change on neurophysiology reflected the impacts of PRRT2 mutations on human neurophysiology
Association of maternal Vitamin D status with glucose tolerance and caesarean section in a multi-ethnic Asian cohort: the growing up in Singapore towards healthy outcomes study
- Author
- Biswas Arijit
- Broekman Birit Froukje Philippien
- Cai Shirong
- Chan Kok Yen Jerry
- Chan Yiong Huak
- Chee Yin Ing Cornelia
- Cheung Yin Bun
- Chinnadurai Amutha
- Chong Foong Fong Mary
- Chong Shang Chee
- Chua Mei Chien
- Gluckman Peter David
- Goh Yam Thiam Daniel
- Gooley Joshua J.
- Holbrook Joanna Dawn
- Hsu Chin-Ying Stephen
- Kwek Yung Chiang Kenneth
- Lee Bee Wah
- Lee Yung Seng
- Lek Ngee
- Loy See Ling
- Natarajan Padmapriya
- Niduvaje Krishnamoorthy
- Pang Wei Wei
- Qiu Anqi
- Rajadurai Victor Samuel
- RAUFF HOW JING MARY
- Rebello Salome Antonette
- Rob Martinus van Dam
- Saw Seang Mei
- Shek Pe-Chi Lynette
- Shuter Borys
- Singh Leher
- Soh Shu E.
- Su Lin Lin
- Tan Kok Lian
- Teoh Oon Hoe
- Tint Mya Thway
- Van Bever Hugo P.S.
- Wong Peng Cheang
- Yap Kok Peng Fabian
- Yeo George S. H.
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/11/2015
- Field of study
10.1371/journal.pone.0142239PLoS ONE10111-16GUSTO (Growing up towards Healthy Outcomes
Paraoxonase-1 Is Not a Major Determinant of Stent Thrombosis in a Taiwanese Population
- Author
- AR Shuldiner
- AS Aynacioglu
- B Giusti
- BS Shin
- C Frere
- Chao-Yung Wang
- Cheng-Hung Lee
- Chun-Chi Chen
- D Sibbing
- D Sibbing
- D Trenk
- DE Cutlip
- DJ Angiolillo
- Dong-Yi Chen
- F Mangiacapra
- F Sofi
- Fun-Chiung Lin
- HH Wang
- HJ Bouman
- I-Chang Hsieh
- JD Snoep
- Jian-Liang Wang
- JL Mega
- JP Lewis
- JS Hulot
- JS Hulot
- JT Brandt
- K Umemura
- Laing-Suei Lu
- M Kazui
- M O’Donoghue
- M Zabalza
- Michael Lipinski
- Ming-Jer Hsieh
- Ming-Shien Wen
- Ming-Ta Lee
- P Fontana
- PA Gurbel
- S Yusuf
- SA Oliveira
- San-Jou Yeh
- Shang-Hung Chang
- T Simon
- T Simon
- Tsong-Hai Lee
- VL Serebruany
- WF Li
- WH Pan
- X Wang
- Y Luo
- Y Shi
- Yen Chu
- Publication venue
- Public Library of Science
- Publication date
- 18/06/2012
- Field of study
BACKGROUND: Clopidogrel is a prodrug that undergoes in vivo bioactivation to show its antiplatelet effects. Recent studies have shown that cytochrome P450 (CYP), ATP-binding cassette transporters (ABCB1), and paraoxonase-1 (PON1) play crucial roles in clopidogrel bioactivation. Here, we aim to determine the effects of genetic polymorphisms of CYP (CYP 2C19*2, CYP 2C19*3, and CYP 2C19*17), ABCB1 (ABCB1 3435C>T, ABCB1 129T>C, and ABCB1 2677G>T/A), and PON1 (PON1 Q192R, PON1 L55M, and PON1 108C>T) on the development of stent thrombosis (ST) in patients receiving clopidogrel after percutaneous coronary intervention (PCI). METHODS AND RESULTS: We evaluated the incidence of ST (0.64%) in 4964 patients who were recruited in the CAPTAIN registry (Cardiovascular Atherosclerosis and Percutaneous TrAnsluminal INterventions). The presence of genetic polymorphisms was assessed in 20 subjects who developed ST after aspirin and clopidogrel therapy and in 40 age- and sex-matched control subjects who did not develop ST, which was documented after 9 months of angiographic follow-up. ST was acute in 5 subjects, subacute in 7, late in 7, and very late in 1. The presence of CYP 2C19*2 allele was significantly associated with ST (adjusted odds ratio [ORadj]: 4.20, 95% confidence interval [CI], 1.263-9.544; P = 0.031). However, genetic variations in PON1 and ABCB1 showed no significant association with ST. CONCLUSION: We conclude that in a Taiwanese population, PON1 Q192R genotype is not associated with ST development after PCI. However, the presence of CYP 2C19*2 allele is a risk factor for ST development after PCI
Invigorating 'Nanoethics':Recommendations for Improving Deliberations in Taiwan and Beyond
- Author
- A Ferrari
- A Hullman
- A Hullman
- A Maynard
- A Nordmann
- A Rip
- C Kallinger
- C Mody
- C Palmberg
- C Wilkinson
- D Baird
- D Fischer
- D Johnson
- D Jones
- D Koepsell
- D Sarewitz
- E Drexler
- Expert Panel on Nanotechnology
- G Foladori
- G Gaskell
- G Marchant
- H Arendt
- H Atlan
- H Manoharan
- H Nowotny
- J D’Silva
- J Uldrich
- JP Dupuy
- KT Chou
- M Cobb
- M Lemley
- M Powell
- M Ratner
- N Pidgeon
- O Renn
- R Aitken
- R Bawa
- R Williams
- Royal Society Royal Academy of Engineering
- S Friedrichs
- S Harmon
- S Harmon
- S Harmon
- S Harmon
- S Harmon
- Shang-Yung Yen
- Shawn H. E. Harmon
- Shu-Mei Tang
- SY Song
- T Rogers-Hayden
- T Sheetz
- T Swierstra
- TH Tai
- W Benjamin
- W Zhou
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2011
- Field of study
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
- Author
- A Kaldun Nossuli
- Aamir Jamal
- Adalbert Schiller
- Adam Cheifetz
- Adarsh Daswani
- Adeera Levin
- Adline Ghazi
- Adrian Guinsburg
- Adriana Cif
- Adriana Gabriela Onaca
- Adriana Ilavska
- Adriana Villarino
- Agarwal R.
- Agnieszka Starzec
- Ahmed Arif
- Ahmed Awad
- Aiping Yin
- Akimichi Asano
- Alan Jackson
- Alan McMahon
- Alan Perlman
- Alberto Di Carlo
- Alberto Esquenazi
- Alejandra Oviedo
- Alejandro Valdes Depeda
- Aleksandra Kendereski
- Alex Valenzuela
- Alexander Dreval
- Alexander Gonzalez
- Alexander Shinkov
- Alexander Turchin
- Alexandre Klein
- Alfonso Soto Gonzalez
- Alfred Penfornis
- Alfredo Chew Wong
- Alfredo Wassermann
- Ali Torshizi
- Alicia Chilito
- Alina Agafyina
- Alison Dawson
- Alva Hansraj
- Amer Al-Karadsheh
- Amorin Remus Popa
- Amrendra Kumar
- Amy Sprague
- Ana Limos
- Ana Maria Cusumano
- Ana Maria Elosegui
- Anabella Amigo
- Anatoliy Kazmirchuk
- Andrea Phillips
- Andrea Stella
- Andreas Maddux
- Andrej Dzupina
- Andres Alvarisqueta
- Andrew Johnson
- Andrew O'Shaughnessy
- Andrew Steele
- Andrian Yakov
- Andrzej Januszewicz
- Andrzej Madej
- Angelina Angelova
- Anibal Gastaldi
- Anil Gupta
- Anita Bhajan Manocha
- Anjanette Tan
- Anna Kaminska
- Anna Maria Veronelli
- Anna Strzelecka
- Anna Zateyshchikova
- Anselmo Bordonava
- Antanas Navickas
- Anthony Gunstone
- Anthony Roberts
- Antonio Ceriello
- Antonio Galan Serrano
- Antonio Scafuto Scotton
- Antonio Terrelonge
- Antônio Roberto Chacra
- Anupama Gowda
- Arjun D Sinha
- Armando Perez
- Ashot Mkrtumyan
- Atanas Koundurdjiev
- Augusto Vallejos
- Aurelian-Emil Ranetti
- Ayim Akyea-Djamson
- Aysha Badat
- Bakris G.
- Baldev Singh
- Barbara Greco
- Barbara Kaczmarek
- Barbara Rewerska
- Barry M Brenner
- Belia Martin Del Camp Blanco
- Bernard Zinman
- Bertrand Cariou
- Bertrand Dussol
- Bhasker Mehta
- Bhimavarapu Sudhakar
- Björn Paschen
- Bompoint S.
- Borys Mankovskyy
- Botond Csiky
- Boyan Nonchev
- Brenner B. M.
- Brett Kissela
- Brian Nichol
- Bruce Neal
- Bruce Trippe
- Bruno Geloneze Neto
- Bull S.
- Byung-Wan Lee
- C B Keshavamurthy
- Cannon C. P.
- Capuano G.
- Carlo Giorda
- Carlos Alberto Cuneo
- Carlos Arauz-Pacheco
- Carlos Barrera
- Carlos Perez
- Carmel Hawley
- Carmen Crisan
- Carol Pollock
- Carolyn Droste
- Caroucel Chuateco
- Caryl David
- Cecilia Garcia Ballesteros
- Cecilia Jimeno
- Celso Amodeo
- Cesar Javier Zaidman
- Cesar Yoiti Hayashida
- Chamberlain Obialo
- Chang-Hsun Hsieh
- Charles Cook
- Charles Kaupke
- Charytan D. M.
- Chek Loong Loh
- Chen Leia
- Cheol-Young Park
- Chih-Ching Lin
- Christopher P Cannon
- Christy Yao
- Chu P. -L.
- Chwen-Tzuei Chang
- Chye Lee Gan
- Clara Barrios
- Claude Galphin
- Claudia Goycoa
- Claudia Moreira de Brito
- Clodoaido Caringal
- Cristian Serafinceanu
- Cristina Toarba
- Cristobal Morales Portillo
- Csaba Kovesdy
- Cynthia Bowman-Stroud
- Cynthia Christiano
- Cynthia Mustieles Rocha
- Cyrus Desouza
- Cássio Slompo Ramos
- Dagmar Bartaskova
- Dale Crawford Allison
- Dalia Kozloviene
- Dan Scharfstein
- Dana Cosma
- Daniel Coyne
- Daniel Hiser
- Daniel Kolansky
- Daniel Panarotto
- Daniel Pella
- Daniel Weiner
- Daniil Chizhov
- Dariusz Sowinski
- Darren K McGuire
- Davesh Sennik
- David C Wheeler
- David Cherney 3rd
- David Gorson
- David Johnson
- David M Charytan
- David Packham
- David Scott
- David Wheeler
- De Zeeuw D.
- Debbie Cohen-Stein
- Debbie Mascaro
- Deepak Koppolu
- Dennis Levinson
- Derek Lewis
- Detian Li
- Devasmita Dev
- Devesh Patel
- Dewan Deepak
- Dick de Zeeuw
- Diego Aizenberg
- Dinesh Jain
- Dinesh Khullar
- Diogo Belo
- Dmitry Zateyshshikov
- Domenico Santoro
- Domingos d'Avila
- Donald Brandon
- Donald Fraser
- Dong-Wan Chae
- Dora Inés Molina de Salazar
- Dorota Mlodawska-Choluj
- Doru Negru
- Edgar Arcos
- Edoardo Mannucci
- Eduardo Farias
- Edward Watson
- Edwards R.
- Egle Gaupsiene
- Egle Urbanaviciene
- Ekaterina Velichkova
- Elena Christofides
- Elena Grineva
- Elena Kolmakova
- Elena Shutemova
- Eleonora Harcsa
- Elizabeth Barranco
- Elizabeth Gelersztein
- Elizabeth Kern
- Elizete Keitel
- Eloisa Tellez Chavez
- Emanuela Orsi
- Emil Martinka
- Emyr Davies
- Enrique Gonzalez
- Eric Alamartine
- Eric Hernandez Triana
- Eric Thervet
- Erick Turcios Juarez
- Esteban Cercos
- Eugenia Galindo-Ramos
- Eva Peterfai
- Evaly Chen
- Evandro de Souza Portes
- Evgueniy Vazelov
- Fabian Otreras
- Fabiana Loss de Carvalho Contieri
- Fabio Malberti
- Fadi Saba
- Fadlo Fraige Filho
- Favio Edmundo Enriquez Sosa
- Fayzal Ahmed
- Ferdinando Carlo Sasso
- Fernanco Augusto Alves da Costa
- Fernanda Cristina Camelo Sanches
- Fernando Cereto Castro
- Fernando Flores Lozano
- Fernando Jimenez Florez
- Fernando Krynski
- Fernando M Edwin
- Fernando Thomé
- Fernando Trespalacios
- Florence Santos
- Florencia Kraft
- Fracisco Javier Gonzalez Martinez
- Fran Morren
- Franciso Jose Tinahones Madueno
- Frank Eder
- Franklin Joseph
- Franklin Paul Haase
- Frantisek Saudek
- François Dubé
- François Madore
- Freemu Varghese
- Gabriela Cecilia Coloma
- Gabriela Genova-Hristova
- Gabriele von Ingersleben
- Gaetano Serviddio
- Galina Nagibovich
- Gary Meininger
- Gema Fernandez Fresnedo
- Georg Plassmann
- George Bakris
- George Hon
- George Newman
- Gerald DaRoza
- Gerald Keightley
- Gerry Tan
- Giacomo Garibotto
- Giorgio Fuiano
- Giovanni Frascà
- Giovanni Gambaro
- Giuseppe Derosa
- Gizella Petro
- Glenn Chertow
- Gnyandev Patel
- Godwin Simon
- Goga Vukotic
- Gopal Krishna
- Grace Aquitania
- Grace Lin
- Graham Hillis
- Graziano Di Cianni
- Grazyna Orlowska-Kowalik
- Grazyna Popenda
- Greene T.
- Greg Fulcher
- Gregorio Obrador
- Gregorio Obrador Vera
- Grit Faulmann
- Guadalupe Morales Franco
- Guillermo Fragale
- Guixia Wang
- Gulam Latiff
- Gustavo Cristian Greloni
- Guy Chouinard
- Gyongyi Csecsei
- Gyorgy Paragh
- Halyna Tomashkevych
- Hans Prozesky
- Harpreet Bajaj
- Hasnain Khandwala
- Hector Rodriguez
- Heerspink H. J. L.
- Helena Oosthuizen
- Hendrik Nortje
- Henry Watson
- Hermann Haller
- Hernan Finkelstein
- Hernan Yupanqui
- Hiddo J L Heerspink
- Hiralal Maheshwari
- Hiroko Oishi
- Hiromi Aoki
- Hiromi Rodriguez Pattzi
- Hiroshi Kono
- Hitoshi Akiyama
- Holly Wang
- Hong Mao
- Hong Zhang
- Hongguang Zheng
- Hongli Lin
- Horacio Sessa
- Hugo Colombo
- Hugo Laviada Molina
- Hugo Roberto Kurtz Lisboa
- Humberto Pavon
- Hyuk-Sang Kwon
- Iain MacDougall
- Ian Fraser
- Idalia Acosta
- Ildiko Halmagyi
- In-Kyung Jeong
- Ines Bartolacci
- Ingrid Abrahamsen
- Ingrid Buganova
- Inna Kolesnyk
- Ioana Emilia Ferariu
- Irene Noronha
- Irina Glinkina
- Irina Osipova
- Iryna Dudar
- Isabel Erika Rucker Joerg
- Isabel Garcia
- Isam Marar
- Israel Hartman
- Iuliia Komisarenko
- Ivan Fushtey
- Ivan Ory
- Ivan Rychlik
- Ivan Rychlík
- Ivan Smirnov
- Ivan Topchii
- Ivan Villegas
- Iveta Smatanova
- Jaco Jurgens
- Jakkidi Reddy
- Jamal Hammoud
- James Conway
- James Januzzi
- James Welker
- Jan Culak
- Jana Babikova
- Jana Belobradkova
- Jana Dzuponova
- Janos Mucsi
- Jardine M. J.
- Jason Gaglia
- Javier Narvarte
- Javier Nieto Iglesias
- Jayameena Peringat
- Jayant Kumar
- Jean Carlo Tibes Hachmann
- Jean Welsh
- Jean-Pierre Fauvel
- Jeevren Reddy
- Jeffrey Kropp
- Jeffrey Stephens
- Jeimeen Agra
- Jelena Ignjatovic
- Jesus Cuadrado
- Jesus Egido de Los Rios
- Jian Liu
- Jiao Sun
- Jinkui Yang
- Jiri Lastuvka
- Jiri Pumprla
- Joaquin Pablo Gonzalez
- Johannes Breedt
- John Amerena
- John Baker
- John Ervin
- John Evans
- John Lentz
- John Middleton
- John Padron
- John Sensenbrenner
- John Updegrove
- John Wakeling
- Jonay Pantoja Perez
- Jorge Archibaldo Glenny
- Jorge Avendano
- Jorge Ernesto Andres Diaz Ruiz
- Jorge Hector Resk
- Jorge Kusnir
- Jorge Mordujovich
- Jorgelina Sala
- Jose Antonio Sánchez Arenales
- Jose Chevaile Ramos
- Jose David Gomez Rangel
- Jose Esteban Jodar Gimeno
- Jose Francisco Kerr Saraiva
- Jose Hector Sanchez Mijangos
- Jose L Górriz
- Jose Luis Accini Mendoza
- Jose Ma Portoles Perez
- Jose Osvaldo Fretes
- Jose Ricardo Correa Rotter
- Joseph Abdallah
- Joseph Aiello
- Joseph Feuerstein
- Joseph O'Hare
- Joseph Proietto
- Josier Nisnisan
- José Vicente Sanchez Polo
- João Lindolfo Cunha Borges
- João Soares Felício
- Juan Alfredo Tamayo Y Orozco
- Juan Baas Cruz
- Juan Carlos Santos
- Juan Diego Higuera
- Juan Frias
- Juan Gonzalo Godoy Jorquera
- Juan Pablo Albisu
- Juan Pablo Moreira Diaz
- Juan Peralta Calcaneo
- Juan Rosas Guzman
- Juan Villagordoa Mesa
- JungEun Lee
- Kamal Abouglila
- Karel Peterka
- Karina Hufert
- Karlton Pettis
- Katalin Keltai
- Katalin Revesz
- Katarina Halciakova
- Katarina Lalic
- Kathy Nicholls
- Kati De Brouwer
- Kazuhiro Yanagida
- Kazunori Koyama
- Kazuyuki Mizuyama
- Kee Sing Ng
- Kenneth Cohen
- Kenneth Deck
- Kenneth Hershon
- Kenneth Liss
- Kenneth W Mahaffey
- Khalid Abdul Kadir
- Khurram Wadud
- Kim Travis
- Kiril Hristozov
- Kook-Hwan Oh
- Krisztian Kiss
- Kun Ho Yoon
- Lachezar Lozanov
- Lajos Major
- Lalaine Delos Santos
- Landman Lombard
- Larisha Pillay-Ramaya
- Larry Distiller
- Larysa Pererva
- Laszlo Deak
- Laszlo Konyves
- Laura Akright
- Laura Coffee
- Lawrence Distiller
- Lawrence Lehrner
- Lawrence Leiter
- Lech Lazuka
- Lee-Ming Chuang
- Lenka Dohnalova
- Leslie Spry
- Levin A.
- Li Yuan Lee
- Lidia Bermudez
- Ligia Petrica
- Lilia Beatriz Schiavi
- Liliana Monica Angelescu
- Liliia Zub
- Liliya Martynyuk
- Lin Sun
- Lincoln Chapin
- Linong Ji
- Lisa Rich
- Liudmila Kvitkova
- Lori Yost
- Luca Chiovato
- Luca De Nicola
- Luca Zanoli
- Lucas Rista
- Luciane Mônica Deboni
- Lucyna Hotlos
- Ludger Rose
- Luigi Gnudi
- Luis Alberto Ramirez Roca
- Luis Asmarats Mercadal
- Luis David Abraira Munoz
- Luis Enrique Herrera Jimenez
- Luis Fernando Flota Cervera
- Luis Henrique Canani
- Luis Hernando Garcia Ortiz
- Luis Isaias Juncos
- Luis Quesada-Suarez
- Luis Rodolfo Cartasegna
- Luis Valderrama Cometa
- Luis Venegas Carrillo
- Luiz Alberto Andreotti Turatti
- Luiza Despina Demian
- László Rosivall
- Ma Dovie Lallaine Ygpuara
- Mahaffey K. W.
- Manel Terns Riera
- Manish Saxena
- Manthi Hettiarachchi
- Manuel Muñoz Lopez Mendoza
- Manuel Muñoz Torres
- Manuela Schmidt
- Marc Rendell
- Marcel Twahirwa
- Marcelo Medina Fariña
- Marcora Mandreoli
- Marcus Gomes
- Margarita Temelkova
- Margarita Vejar
- Margit Mileder
- Margo Hudson
- Maria Antonia Munar Vila
- Maria Barnard
- Maria Cecilia Cantero
- Maria Florencia Fernandez
- Maria Isabel Klyver
- Maria Jaime
- Maria Rosa Ulla
- Maria Teresa Zanella
- Maria Valdez
- Marializa Bernardo
- Marianna Zsom
- Mario Alberto Berli
- Mario Burgos Soto
- Mark Davies
- Mark Vannorsdall
- Mark Warren
- Markus Faghih
- Marsha Tolentino
- Marta Dominquez Lopez
- Marta Molnar
- Martin Lukac
- Martin Valis
- Martine Destree
- Mary Anne Lim-Abrahan
- Mary Lawrence
- Mary Seeber
- Maryna Vlasenko
- María Alicia Fernández Montenegro
- María Angustias Quesada Simón
- Masahiko Takai
- Masahiro Koizumi
- Masakiyo Wakasugi
- Masayo Yamada
- Mastura Ismail
- Matthew Abramowitz
- Matthew Beacom
- Meg J Jardine
- Meg Jardine
- Meininger G.
- Melchor Alpizar Salazar
- Melemadathil Sreelatha
- Merce Perez Vera
- Mercedes Velo Plaza
- Michael Oliver
- Michael Robinson
- Michael Shanik
- Michael Thompson
- Michael Williams
- Michal Nowicki
- Michał Nowicki
- Michelle Zaniewski-Singh
- Mick Kumwenda
- Miguel Nazzer Hissa
- Migues Angel Reyes Rosano
- Mihaela Biscoveanu
- Mihaela-Magdalena Busegeanu
- Mihaly Dudas
- Milan Gupta
- Min Jeong Kwon
- Minara Shamkhalova
- Minghui Zhao
- Miodrag Djordjevic
- Mircea Munteanu
- Mitsuru Tsujimoto
- Mohamed El-Shahawy
- Mohamed Mookadam
- Mohamed Railey
- Mohamed Sekkarie
- Mohanram Narayanan
- Mohd Daud Che Yusof
- Mohsen El Kossi
- Mona Wahba
- Monica Alexandra Terront Lozano
- Monika Dhillon
- Moogali Arvind
- Moon-Kyu Lee
- Moon-Suk Nam
- Moustafa Moustafa
- Muhammad Shakeel
- Mukesh Joshi
- Mykola Kolesnyk
- Márcio Antônio Pereira
- Nadia Zalunardo
- Nadiya Tryshchuk
- Nan Chen
- Narayan Prasad
- Naresh Aggarwal
- Natalia Malaver
- Nataliia Pashkovska
- Natarajan Gopalakrishnan
- Navdeep Tangri
- Naveen Atray
- Neal B.
- Nebojsa Lalic
- Neil Kumar
- Nelson Kopyt
- Nelson Rodriguez Papini
- Nestor Horacio Garcia
- Ngai Wah Cheung
- Nicolae Hancu
- Nicole Li
- Nik Nur Fatnoon Nik Ahmad
- Nina Patel
- Nizar Daboul
- Noble Gracious
- Nomangesi Ngcakani
- Nonna Kravchun
- Nora Marchetta
- Norman Muirhead
- Norsiah Ali
- Oleg Legun
- Oleg Nagibovich
- Oleg Uriasyev
- Oleksandr Golovchenko
- Oleksandr Samoylov
- Oleksii Korzh
- Olga Barbarash
- Olga Barna
- Olga Barysheva
- Olga Benusova
- Olga Godlevska
- Olga Gyrina
- Olga Sazonova
- Olivert Gomez
- Oomman Abraham
- Osamu Tomonaga
- Oscar Tarsicio Moreno Loza
- Osvaldo Brusco
- Pablo Antonio Novoa
- Pablo Mele
- Pablo Raffaele
- Pablo Serrano Sanson
- Paranthaman Vengadasalam
- Patricia Del Carmen Gonzalez Colaso
- Patrick English
- Patrick Parfrey
- Paul Ainsworth
- Paul Frenk Baron
- Paul Nixon
- Paul Noonan
- Paul Rheeder
- Paulina Virginia Lanchiotti
- Pavel Weiner
- Peak Mann Mah
- Pedro Calella
- Pedro de Souza
- Pedro Velasquez-Mieyer
- Peggy Barnhill
- Peggy Lin
- Pere Alvarez Garcia
- Perkovic V.
- Peter Danos
- Peter Fulop
- Peter Van Buren
- Peter Winocour
- Petr Barton
- Philip Gorelick
- Philip Home
- Philip Nicol
- Philippe Zaoui
- Phyllis August
- Piermarco Piatti
- Pierre Gourdy
- Pierre-Jean Saulnier
- Pietro Castellino
- Pilar Trueba
- Ping Tu
- Pollock C.
- Prasanth Surampudi
- Pusadee Suchinda
- Qinkai Chen
- Rachel Bregman
- Radica Alicic
- Radu Jacob
- Rafael Simo Canonge
- Raied Abdullah
- Rajendran Alappan
- Rajiv Agarwal
- Rajiv Ranjan
- Raju Sree Bhushan
- Rakesh Gulati
- Rakhi Khanna
- Rallabhandi Sankaram
- Raman Purighalla
- Ramesh Chandra Vyasam
- Ramesh Thimmaiah
- Ramon Berenguer
- Ramon Moreda
- Rangel Rangelov
- Rao K Satyanarayana
- Ravendran Govender
- Ravi Sarin
- Reddy Sreedhar
- Reginald Parker
- Rehan Symonds
- Reinhold Jerwan-Keim
- Remi Rabasa-Lhoret
- Renan Montenegro Junior
- Renata Bijata-Bronisz
- Rhea Severina Comia
- Rhonda Bentley-Lewis
- Riad Darwish
- Ricardo Alfonso Leon de la Fuente
- Ricardo Dario Dran
- Ricardo Rosero
- Riccardo Bonadonna
- Richard Ferkl
- Richard Kovar
- Richard Lindley
- Richard Orozco Castellanos
- Richard Solomon
- Robert Busch
- Robert Cohen
- Robert Schreiman
- Robert Takacs
- Robert Walker
- Roberto Abrão Raduan
- Roberto Jorge da Silva Franco
- Roberto Pecoits Filho
- Roberto Pecoits-Filho
- Roberto Simões de Almeida
- Roberto Trevisan
- Rodica-Ioana Avram
- Rodolfo Andres Ahuad Guerrero
- Rohana Abdul Ghani
- Rohit Pankhaniya
- Rolando Zamarripa Escobedo
- Ronald Goldenberg
- Ronald Harris
- Ronald Watts
- Ronaldo Arturo Gonzalez Orellana
- Ronan Roussel
- Ronnie Aronson
- Rosa Isela Luna Ceballos
- Rosângela Milagres
- Ruben Dario Vargas Alonso
- Rury Holman
- Russell Scott
- Sacha De Serres
- Sahay Manisha
- Saiful Shahrizal Bin Shudim
- Sailaja Ventrapragada
- Salah Abusnana
- Salvatore De Cosmo
- Sam Henein
- Sam Philip
- Samuel Cohen
- Samuel Mujica Trenche
- Samy Hadjadj
- Sandor Keresztesi
- Sandor Vangel
- Sandra Berenice Saaveddra Sanchez
- Sanjeev Rastogi
- Sara Jaffer
- Sarah Olelewe
- Satoshi Ota
- Satu Pesickova
- Scott Kasner
- Secundino Cigarran Guldris
- Senan Sultan
- Serge Cournoyer
- Sergei Nedogoda
- Sergey Vorobyev
- Sergio Saul Irizar Santana
- Shahabul Arfeen
- Shahnaz Shahinfar
- Shang-Jyh Hwang
- Shelley Williams
- Shenaz Ramtoola
- Shenglian Gan
- Sherry Sussman
- Shizuo Kajiyama
- Shozo Miyauchi
- Silvia Ines Orio
- Silvia Nicolai
- Simon Davies
- Simon Roger
- Simon Young
- Sin Gon Kim
- Singhan Krishnan
- Sini George
- Slobodan Antic
- Sohan Dua
- Sonia Hermida
- Soo Kun Lim
- Sophie Borot
- Souhila Ounadjela
- Sreedhar Mandayam
- Srikanth Bellary
- Stanislav Zemek
- Stanislaw Mazur
- Stefan Dimitrov
- Stephan Maxeiner
- Stephen Grubb
- Stephen Smith
- Steven Fishbane
- Stuart Handelsman
- Suely Keiko Kohara
- Sun Kim
- Sun-Hee Park
- Sunil Sheth
- Susumu Kashine
- Svetlana Goykhman
- Svitlana D Bilyk
- Swee Win Lam
- Sylvia Rosas
- Sylvia Shaw
- Szilard Vasas
- Sérgio Alberto Cunha Vêncio
- Sérgio Yamada
- Tadashi Iitsuka
- Takamoto Kodera
- Takashi Wada
- Takayuki Watanabe
- Tamara Malek Marin
- Tamas Oroszlan
- Tara Chang
- Tareq Nassar
- Tarissa Beatrice Zanata Petry
- Tatiana Koroleva
- Tatiana Morugova
- Tatiana Raskina
- Tatyana Zykova
- Te-Lin Hsia
- Terue Sakakibara
- Tetiana Zlova
- Tetsuji Niiya
- Tetyana Pertseva
- Tiago Schuch
- Timothy Hall
- Tom Christensen
- Tom Greene
- Tomas Drasnar
- Tomas Smith Casabella
- Tonatiu Diaz Escalante
- Toshihiko Yanase
- Toshio Kawada
- Vadym Vizir
- Vanassa Ratnasingam
- Venessa Tsang
- Venkata Behara
- Vera Klokocnikova
- Vera Krane
- Veronica Anghel
- Veselka Genadieva
- Vesna Popovic-Radinovic
- Viacheslav Marasaev
- Victor Commendatore
- Victor Saavedra Gajardo
- Vijayaraman Arutchelvam
- Viktor Margaritov
- Viktor Zaviriukha
- Viktoria Andreeva
- Vimladhevi Govender
- Vincent Pichette
- Vincent Woo
- Vira Tseluyko
- Virginia Esther Visco
- Vivek Sood
- Vivekan Jha
- Vladimir Dobronravov
- Vladimir Khirmanov
- Vladimir Tesar
- Vlado Perkovic
- Volker Burst
- Volodymyr Botsyurko
- Walter Guillermo Douthat
- Walter Pharr
- Wasim Hanif
- Wataru Yumita
- Wayne H-H Sheu
- Wayne Turner
- Wei Yen Kong
- Weihong Song
- Weiping Lu
- Wendy Lane
- Wenge Li
- Wheeler D. C.
- Wladmir Saporito
- Xuemei Li
- Xueqing Yu
- Yamil Canaan
- Yan Ren
- Yannick Le Meur
- Yaozhong Kong
- Yasuro Kumeda
- Yasushi Wakida
- Yavin Y.
- Yeong Hoon Kim
- Yevgeniya Svyshchenko
- Young Min Cho
- Yulia Samoylova
- Yung-Chuan Lu
- Yuriy Mostovoy
- Yuriy Shwartz
- Yvette Ethel Yap
- Zaynab Abejuela
- Zdravko Kamenov
- Zeid Khitan
- Zhang H.
- Zinman B.
- Zishan Ali
- Zuzana Ochodnicka
- Ângela Regina Nazario Sabbag
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
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- Abdel-Aziz AK
- Abdelfatah S
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- Álvarez ÉMC
- Ávalos Y
- Önal G
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- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
- Abdoli A.
- Abel S.
- Abeliovich H.
- Abildgaard M. H.
- Abudu Y. P.
- Acevedo-Arozena A.
- Adamopoulos I. E.
- Adeli K.
- Adolph T. E.
- Adornetto A.
- Aflaki E.
- Agam G.
- Agarwal A.
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- Aguilar P. V.
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- Ahumada-Castro U.
- Aits S.
- Aizawa S.
- Akkoc Y.
- Akoumianaki T.
- Akpinar H. A.
- Al-Abd A. M.
- Al-Akra L.
- Al-Gharaibeh A.
- Alaoui-Jamali M. A.
- Alberti S.
- Alcocer-Gomez E.
- Alessandri C.
- Ali M.
- Alim Al-Bari M. A.
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- Alizadeh J.
- Almacellas E.
- Almasan A.
- Alonso A.
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Patenting genes Is there a moral entitlement towards the ownership of genetic information?
- Author
- Publication venue
- Sheffield (United Kingdom) : University of Sheffield
- Publication date
- 01/01/2002
- Field of study
SIGLEAvailable from British Library Document Supply Centre- DSC:DXN060444 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
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