Practical Peptide Synthesis Mediated by a Recyclable Hypervalent Iodine Reagent and Tris(4-methoxyphenyl)phosphine

6-(3,5-Bis­(trifluoromethyl)­phenyl)-1<i>H</i>,4<i>H</i>-2aλ³-ioda-2,3-dioxacyclopenta­[<i>hi</i>]­indene-1,4-dione (<i>p</i>-BTFP-iodosodilactone, <b>1a</b>) was synthesized and demonstrated to be an efficient hypervalent iodine­(III) reagent for the synthesis of dipeptides from various standard amino acids, including sterically hindered amino acids, in good to high yields within 30 min in the presence of tris­(4-methoxyphenyl)­phosphine. In addition, the combined system of <b>1a/</b>(4-MeOC₆H₄)₃P was used to synthesize the pentapeptide leu-enkephalin in protected form. It is worth noting that <b>1a</b> can be regenerated readily after reaction

A Mild and Efficient Direct α-Amination of β-Dicarbonyl Compounds Using Iodosobenzene and <i>p</i>-Toluenesulfonamide Catalyzed by Perchlorate Zinc Hexahydrate

A direct α-amination of β-dicarbonyl compounds has been achieved by using iodosobenzene (PhIO) as an oxidant and <i>p</i>-toluenesulfonamide (TsNH₂) as an aminating reagent in the presence of a catalytic amount of perchlorate zinc hexahydrate. The present amination reaction proceeds quickly at rt (<30 min needed for most tested substrates) to provide the corresponding α-<i>N</i>-tosylamido β-dicarbonyl compounds in high to excellent yields

Robotic radical hysterectomy is superior to laparoscopic radical hysterectomy and open radical hysterectomy in the treatment of cervical cancer

<div><p>Objective</p><p>Cervical cancer (CC) continues to be a global burden for women, with higher incidence and mortality rates reported annually. Many countries have witnessed a dramatic reduction in the prevalence of CC due to widely accessed robotic radical hysterectomy (RRH). This network meta-analysis aims to compare intraoperative and postoperative outcomes in way of RRH, laparoscopic radical hysterectomy (LTH) and open radical hysterectomy (ORH) in the treatment of early-stage CC.</p><p>Methods</p><p>A comprehensive search of PubMed, Cochrane Library and EMBASE databases was performed from inception to June 2016. Clinical controlled trials (CCTs) of above three hysterectomies in the treatment of early-stage CC were included in this study. Direct and indirect evidence were incorporated for calculating values of weighted mean difference (WMD) or odds ratio (OR), and drawing the surface under the cumulative ranking curve (SUCRA).</p><p>Results</p><p>Seventeen 17 CCTs were ultimately enrolled in this network meta-analysis. The network meta-analysis showed that patients treated by RRH and LRH had lower estimated blood loss compared to patients treated by ORH (WMD = -399.52, 95% CI = -600.64~-204.78; WMD = -277.86, 95%CI = -430.84 ~ -126.07, respectively). Patients treated by RRH and LRH had less hospital stay (days) than those by ORH (WMD = -3.49, 95% CI = -5.79~-1.24; WMD = -3.26, 95% CI = -5.04~-1.44, respectively). Compared with ORH, patients treated with RRH had lower postoperative complications (OR = 0.21, 95%CI = 0.08~0.65). Furthermore, the SUCRA value of three radical hysterectomies showed that patients receiving RRH illustrated better conditions on intraoperative blood loss, operation time, the number of resected lymph nodes, length of hospital stay and intraoperative and postoperative complications, while patients receiving ORH demonstrated relatively poorer conditions.</p><p>Conclusion</p><p>The results of this meta-analysis confirmed that early-stage CC patients treated by RRH were superior to patients treated by LRH and ORH in intraoperative blood loss, length of hospital stay and intraoperative and postoperative complications, and RRH might be regarded as a safe and effective therapeutic procedure for the management of CC.</p></div

SUCRA values of three treatment modalities under six endpoint outcomes.

<p>SUCRA values of three treatment modalities under six endpoint outcomes.</p

Weighted mean difference or odds ratio (95% confidence intervals) of three treatment modalities of six endpoint outcomes.

<p>Weighted mean difference or odds ratio (95% confidence intervals) of three treatment modalities of six endpoint outcomes.</p

Quality assessment based on PEDro scale of clinical controlled trials included in the network meta-analysis.

<p>Note: PEDro = Physiotherapy Evidence Database.</p

Relative relationship forest plots of estimated blood loss (ml), hospital stay (days) and postoperative complications of RRH, LRH and ORH in the treatment of early-stage CC.

<p>Note: A = RRH (robotic radical hysterectomy); B = LRH (laparoscopic radical hysterectomy); C = ORH (open radical hysterectomy).</p

Funnel plot of estimated blood loss (ml), operative time (min), number of pelvic lymph nodes removed, intraoperative complications, hospital stay (days) and postoperative complications of RRH, LRH and ORH in the treatment of early-stage CC.

<p>Note: A = RRH (robotic radical hysterectomy); B = LRH (laparoscopic radical hysterectomy); C = ORH (open radical hysterectomy).</p

WMD/OR values and <i>P</i> values of direct and indirect pairwise comparisons of three treatment modalities under six endpoint outcomes.

<p>WMD/OR values and <i>P</i> values of direct and indirect pairwise comparisons of three treatment modalities under six endpoint outcomes.</p

Pairwise meta-analysis in terms of six endpoints.

<p>Pairwise meta-analysis in terms of six endpoints.</p