11 research outputs found
Destroying the Shield of Cancer Stem Cells: Natural Compounds as Promising Players in Cancer Therapy
In a scenario where eco-sustainability and areduction in chemotherapeutic drug waste are certainly a prerogative to safeguard the biosphere, the use of natural products (NPs) represents an alternative therapeutic approach to counteract cancer diseases. The presence of a heterogeneous cancer stem cell (CSC) population within a tumor bulk is related to disease recurrence and therapy resistance. For this reason, CSC targeting presents a promising strategy for hampering cancer recurrence. Increasing evidence shows that NPs can inhibit crucial signaling pathways involved in the maintenance of CSC stemness and sensitize CSCs to standard chemotherapeutic treatments. Moreover, their limited toxicity and low costs for large-scale production could accelerate the use of NPs in clinical settings. In this review, we will summarize the most relevant studies regarding the effects of NPs derived from major natural sources, e.g., food, botanical, and marine species, on CSCs, elucidating their use in pre-clinical and clinical studies
Identification of miRNAs and the target genes related to male infertility and smoking using bioinformatics approaches
Drinking frequency in last 12 months (at national level by age groups).
Drinking frequency in last 12 months (at national level by age groups).</p
Current alcohol drinking prevalence map of Iran, 2016, https://www.openstreetmap.org/copyright.
Current alcohol drinking prevalence map of Iran, 2016, https://www.openstreetmap.org/copyright.</p
Provincial distribution of alcohol drinking (%) within the past year.
Provincial distribution of alcohol drinking (%) within the past year.</p
The alcohol drinking status and demographic characteristics in Iran, 2016 (National Level).
The alcohol drinking status and demographic characteristics in Iran, 2016 (National Level).</p
Distribution of alcohol drinking among age group by sex and residential status.
Distribution of alcohol drinking among age group by sex and residential status.</p
Pattern of alcohol consumption in Iran in 2016 (National Level).
Pattern of alcohol consumption in Iran in 2016 (National Level).</p
Association of alcohol related disorders with alcohol consumption in logistic regression models: Result from the National Surveillance of Non-Communicable Disease Survey (STEPs).
Association of alcohol related disorders with alcohol consumption in logistic regression models: Result from the National Surveillance of Non-Communicable Disease Survey (STEPs).</p
Association of alcohol related disorders with alcohol consumption in logistic regression models: Results from the National Surveillance of Non-Communicable Diseases Survey (STEPs).
Association of alcohol related disorders with alcohol consumption in logistic regression models: Results from the National Surveillance of Non-Communicable Diseases Survey (STEPs).</p