1 research outputs found
Developing Hybrid Polymer Scaffolds Using Peptide Modified Biopolymers for Cell Implantation
Polymeric
scaffolds containing biomimics offer exciting therapies
with broad potential impact for cellular therapies and thereby potentially
improve success rates. Here we report the designing and fabrication
of a hybrid scaffold that can prevent a foreign body reaction and
maintain cell viability. A biodegradable acrylic based cross-linkable
polycaprolactone based polymer was developed and using a multihead
electrospinning station to fabricate hybrid scaffolds. This consists
of cell growth factor mimics and factors to prevent a foreign body
reaction. Transplantation studies were performed subcutaneously and
in epididymal fat pad of immuno-competent Balb/c mice and immuno-suppressed
B6 Rag1 mice and we demonstrated extensive neo-vascularization and
maintenance of islet cell viability in subcutaneously implanted neonatal
porcine islet cells for up to 20 weeks of post-transplant. This novel
approach for cell transplantation can improve the revascularization
and allow the integration of bioactive molecules such as cell adhesion
molecules, growth factors, etc