Aza-Michael reaction of 12-<i>N</i>-carboxamide of (–)-cytisine under high pressure conditions

<div><p>The first example of aza-Michael reaction of 12-<i>N</i>-carboxamide of quinolizidine alkaloid (–)-cytisine with α,β-unsaturated ketones, dimethyl acetylenedicarboxylate and β-nitrostyrene under high pressure condition has been described. It has been shown that the [4+2]-cycloaddition takes place in the case with <i>N</i>-phenylmaleimide.</p></div