1,051 research outputs found
Reactions with 5-Arylazo- and 5-Arylidene-4-thiohydantoin Derivatives
5-Arylazo-3-phenyl-4-thiohydantoins (IIa-g) have been prepared
and then treated with primary aromatic amines to afford the
corresponding 5-arylazo-4-arylimino-3-phenyl hydantoins (VIIa-c).
3-Phenyl-4-thiohydantoin reacted with aromatic aldehydes in the
presence of glacial acetic acid and fused sodium acetate to give
5-arylidene-3-phenyl-4-thiohydantoin derivatives (VIIIa-e). In the
coloured arylidene derivatives (VIII,a d, e) on treatment with alkyland/
or arylmagnesium halide addition occurs to the exocyclic
double bond to give the products (IXa-e). The Grignard product
(Xa) was oxidised with a mixture of chromic acid in glacial acetic
acid to give phenyl parabanic acid and ethyl phenyl ketone
The effect of albumin administration on renal dysfunction after experimental surgical obstructive jaundice in male rats
AbstractThe aim was to study the influence of albumin supplementation on the changes of the kidney function and structure in cirrhotic rats induced by common bile duct ligation (BDL). Twenty-four male albino rats weighing 200–250g were divided into Group I: 6 rats underwent laparotomy alone, and the bile duct was only dissected from the surrounding tissue; Group II: 6 rats underwent a sham operation and received 2% albumin in their drinking water; Group III: 6 rats were subjected to bile duct ligation only; and Group IV: 6 rats were subjected to bile duct ligation and received a daily albumin 2% in drinking water. All rats were sacrificed after 4 weeks. We measured the liver and kidney functions and oxidative stress markers in the renal tissue and conducted a histological evaluation of the liver and kidney. The liver enzymes were decreased, but there was no significant difference in the bilirubin levels in group IV compared to group III. There was a significant elevation of serum creatinine in group III compared to group II, and serum creatinine was attenuated in group IV. The renal tissue catalase activity and reduced glutathione, as well as the nitric oxide levels, were significantly increased in group IV and were elevated in group III. Histologically, the livers of group IV showed degeneration and inflammatory cell infiltration with regeneration areas in which normal hepatocytes appeared. The kidneys of group IV showed recovery as well as areas of inflammatory cell infiltration. Some tubules appeared with normal epithelial lining. In conclusion, the results suggest that albumin partially improves the renal functions and structures after their disturbances as a result of BDL
Combined forced oscillation and forced expiration measurements in mice for the assessment of airway hyperresponsiveness
Study on Quality of Pair Distribution Function for Direct Space Approach of Structure Investigation
Study of the structure characteristics of solid materials is a key for development of technological applications. Potential of direct space approach for structure determination and refinement using powder X-ray diffraction data depend on the quality of pair distribution function (PDF) plot. So, the effect of data collection conditions and diffractogram characteristics on the quality of PDF plot has been investigated in detail. In addition, errors and possible tolerance have been estimated. Some parameters affect only either the X-ray diffractogram or PDF plots and others affect both. Considering the errors and tolerance, direct space approach can be confidently used for structure refinement, where the error did not exceed 10.0 % for inter-atomic radial distance longer than » 2.0 ? and 5.0 % for longer than » 4.0 ?, which is accepted for structure refinement. As tolerance is considered, every time the value of the lattice parameter is changed to smaller or larger than the correct value (+ 8.0 %), it comes back to the initial correct one. Although, advanced synchrotron radiation shows better data, conventional source can be used successfully for structure investigation applying direct space approach
Precise Cerebrovascular Segmentation
© 2020 IEEE. Analyzing cerebrovascular changes using Time-of-Flight Magnetic Resonance Angiography (ToF-MRA) images can detect the presence of serious diseases and track their progress, e.g., hypertension. Such analysis requires accurate segmentation of the vasculature from the surroundings, which motivated us to propose a fully automated cerebral vasculature segmentation approach based on extracting both prior and current appearance features that capture the appearance of macro and micro-vessels. The appearance prior is modeled with a novel translation and rotation invariant Markov-Gibbs Random Field (MGRF) of voxel intensities with pairwise interaction analytically identified from a set of training data sets, while the current appearance is represented with a marginal probability distribution of voxel intensities by using a Linear Combination of Discrete Gaussians (LCDG) whose parameters are estimated by a modified Expectation-Maximization (EM) algorithm. The proposed approach was validated on 190 data sets using three metrics, which revealed high accuracy compared to existing approaches
PHYTOPHENOLICS COMPOSITION, HYPOLIPIDEMIC, HYPOGLYCEMIC AND ANTIOXIDATIVE EFFECTS OF THE LEAVES OF FORTUNELLA JAPONICA (THUNB.) SWINGLE
Objective: Fortunella japonica (Thunb.) Swingle is an evergreen shrub, its whole fruit, including the peel, is eaten. There have been few detailed phytophenolics composition reports on this genus and the hypoglycemic and hypolipidemic effects of the plant were not evaluated. Methods: Structures of the isolated compounds were elucidated by spectral analysis. Serum glucose level, activities of liver enzymes, total protein content, serum lipid profiles, antioxidant parameters and some glycolytic and gluconeogenic enzymes in streptozotocin (STZ)-induced diabetic rats were determined. The evaluation also carried out through determination of liver disorder biomarkers and histopathological examination of liver, kidney and pancreas. Results: Six phytophenolics were isolated, for the first time from the genus Fortunella as well as a sterol compound. Treatment with the ethanolic extract of F. japonica leaves effectively meliorated antioxidant markers and glycolytic enzymes. The histopathological analyzes also confirmed the experimental findings.Conclusion: The results show that the ethanolic extract has hypoglycemic, hypotriglyceridemic and antioxidant effects in STZ-induced diabetic rats, suggesting that this extract supplementation can be useful in preventing diabetic complications associated with hyperlipidemia and oxidative stress.Â
Non-perturbative calculations for the effective potential of the symmetric and non-Hermitian field theoretic model
We investigate the effective potential of the symmetric
field theory, perturbatively as well as non-perturbatively. For the
perturbative calculations, we first use normal ordering to obtain the first
order effective potential from which the predicted vacuum condensate vanishes
exponentially as in agreement with previous calculations. For the
higher orders, we employed the invariance of the bare parameters under the
change of the mass scale to fix the transformed form totally equivalent to
the original theory. The form so obtained up to is new and shows that all
the 1PI amplitudes are perurbative for both and regions. For
the intermediate region, we modified the fractal self-similar resummation
method to have a unique resummation formula for all values. This unique
formula is necessary because the effective potential is the generating
functional for all the 1PI amplitudes which can be obtained via and thus we can obtain an analytic calculation for the 1PI
amplitudes. Again, the resummed from of the effective potential is new and
interpolates the effective potential between the perturbative regions.
Moreover, the resummed effective potential agrees in spirit of previous
calculation concerning bound states.Comment: 20 page
Spatial beam self-cleaning in second-harmonic generation
We experimentally demonstrate the spatial self-cleaning of a highly multimode optical beam, in the process of second-harmonic generation in a quadratic nonlinear potassium titanyl phosphate crystal. As the beam energy grows larger, the output beam from the crystal evolves from a highly speckled intensity pattern into a single, bell-shaped spot, sitting on a low energy background. We demonstrate that quadratic beam cleanup is accompanied by significant self-focusing of the fundamental beam, for both positive and negative signs of the linear phase mismatch close to the phase-matching condition
Dark-Bright Solitons in Inhomogeneous Bose-Einstein Condensates
We investigate dark-bright vector solitary wave solutions to the coupled
non-linear Schr\"odinger equations which describe an inhomogeneous two-species
Bose-Einstein condensate. While these structures are well known in non-linear
fiber optics, we show that spatial inhomogeneity strongly affects their motion,
stability, and interaction, and that current technology suffices for their
creation and control in ultracold trapped gases. The effects of controllably
different interparticle scattering lengths, and stability against
three-dimensional deformations, are also examined.Comment: 5 pages, 5 figure
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