N-alkenylimidazole metal complex derivatives as effective agents for the hypoxic conditions

The therapy of hypoxemic conditions by the substances, which are differing because of their key role in the vital processes of metabolism and also their high pharmacological activity, and which are known to be the regulators of redox systems, can be considered as one of the priority directions of the modern clinical and experimental pharmacology. Metal complexes of essential elements, which are the natural participants of the ligand formation, can be very interesting in this sense. The research goal. Experimental validation of the pharmacological correction of the hypoxic conditions of the N-alkenyl-, Npropargylimidazoles and 3-hydroxypyridine metal complex derivative

Protective Effect of Acyzol in a Model of Carbon Tetrachloride-Induced Hepatotoxicity

© 2016, Springer Science+Business Media New York.The present study investigates the hepatoprotective effect of a novel zinc-containing drug acyzol in comparison with silymarin, a medicinal extract of milk thistle (Silybum marianum). The hepatoprotective effect was studied in 40 albino nonlinear male rats in a model of toxic liver injury induced by intragastric administration of carbon tetrachloride. Both drugs were diluted in water and administered intragastrically at doses 10 mg/kg (acyzol) and 100 mg/kg (silymarin) for 10 days twice daily, after development of clinical toxic hepatitis. Biochemical and functional indicators of the liver parenchyma demonstrated that both drugs reduced mortality, normalized the body and relative liver weight, reduced intensity of cytolytic, cholestatic, and mesenchymal inflammatory syndromes, and restored liver function. The study demonstrates that acyzol and silymarin have comparable hepatoprotective effect, thus, providing a rationale for the use of acyzol in complex therapy of toxic hepatitis and hepatosis

Wushi chuxue Yingwenzi （無師初學英文字） -The research of the difference of the sounds between North and South Mandarin in the late Qing dynasty

記載近代漢語的南北官話或南北官音差異的資料其實不少，「正音」課本之類即是其中一種。相對於中國本土資料多採用漢字說明的方式，西洋人的資料多採用羅馬字對漢字進行注音，這對於音韻研究具有重要意義。本文意在介紹一種描寫近代漢語南北官音差別的資料－『無師初學英文字 General Romanization of the Mandarin Dialect, A Primer for Schools and Self-instruction』（Presbyterian Mission, Nanking 1897)，其作者為 Charles Leaman。這本書里分別「北音」和「南音｣，筆者認為，「北音」大概是廣義的「北方話｣，「南音」則是「以南京官話為主的南方話｣。下面簡單介紹一下這本書的南京官音的描寫情況，並討論西洋傳教士的羅馬字拼音化的問題。文部科学省グローバルCOEプログラム 関西大学文化交渉学教育研究拠点東アジアの言語と表

Pharmacological Correction of Hypoxic Conditions by Complexes of Zinc with N-Alkenylimidazoles

© 2016, Springer Science+Business Media New York.The discovery and development of effective antihypoxic drugs is an important issue in modern experimental and clinical pharmacology. Complexes of zinc containing imidazole cycles as ligands are promising candidates for the design of novel drugs, including pharmacotherapeutic tools for patient’s protection under conditions of oxygen deficiency. Herein, we report antihypoxic activity of zinc complexes with N-alkenylimidazoles, and, specifically, a novel drug Acyzol, which can be used as efficient antidote after poisoning by carbon monoxide and other combustion products

New metal complex of iron as a corrector of physical performance in hypoxia

A comparative study of the influence of metal complex of iron under the code of тetravim and actoprotector bemythyl (metaprot, «Pharmproekt», Russia) and bromantan (ladasten, CJSC «Lecco», Russia) on physical performance white nonlinear mice in normal and complicated hypoxia conditions. It is established, that under normal conditions of тetravim no effect on physical performance, and in hypoxia shows the positive effect that exceeds the action bemythyl and bromantan. The obtained data are of interest for further study of тetravim as a safe and highly efficient corrector of physical performance in the anoxic conditions

N-alkenylimidazole metal complex derivatives as effective agents for the hypoxic conditions

The therapy of hypoxemic conditions by the substances, which are differing because of their key role in the vital processes of metabolism and also their high pharmacological activity, and which are known to be the regulators of redox systems, can be considered as one of the priority directions of the modern clinical and experimental pharmacology. Metal complexes of essential elements, which are the natural participants of the ligand formation, can be very interesting in this sense. The research goal. Experimental validation of the pharmacological correction of the hypoxic conditions of the N-alkenyl-, Npropargylimidazoles and 3-hydroxypyridine metal complex derivative

Protective Effect of Acyzol in a Model of Carbon Tetrachloride-Induced Hepatotoxicity

© 2016, Springer Science+Business Media New York.The present study investigates the hepatoprotective effect of a novel zinc-containing drug acyzol in comparison with silymarin, a medicinal extract of milk thistle (Silybum marianum). The hepatoprotective effect was studied in 40 albino nonlinear male rats in a model of toxic liver injury induced by intragastric administration of carbon tetrachloride. Both drugs were diluted in water and administered intragastrically at doses 10 mg/kg (acyzol) and 100 mg/kg (silymarin) for 10 days twice daily, after development of clinical toxic hepatitis. Biochemical and functional indicators of the liver parenchyma demonstrated that both drugs reduced mortality, normalized the body and relative liver weight, reduced intensity of cytolytic, cholestatic, and mesenchymal inflammatory syndromes, and restored liver function. The study demonstrates that acyzol and silymarin have comparable hepatoprotective effect, thus, providing a rationale for the use of acyzol in complex therapy of toxic hepatitis and hepatosis

Pharmacological Correction of Hypoxic Conditions by Complexes of Zinc with N-Alkenylimidazoles

© 2016, Springer Science+Business Media New York.The discovery and development of effective antihypoxic drugs is an important issue in modern experimental and clinical pharmacology. Complexes of zinc containing imidazole cycles as ligands are promising candidates for the design of novel drugs, including pharmacotherapeutic tools for patient’s protection under conditions of oxygen deficiency. Herein, we report antihypoxic activity of zinc complexes with N-alkenylimidazoles, and, specifically, a novel drug Acyzol, which can be used as efficient antidote after poisoning by carbon monoxide and other combustion products

Pharmacological Correction of Hypoxic Conditions by Complexes of Zinc with N-Alkenylimidazoles

© 2016, Springer Science+Business Media New York.The discovery and development of effective antihypoxic drugs is an important issue in modern experimental and clinical pharmacology. Complexes of zinc containing imidazole cycles as ligands are promising candidates for the design of novel drugs, including pharmacotherapeutic tools for patient’s protection under conditions of oxygen deficiency. Herein, we report antihypoxic activity of zinc complexes with N-alkenylimidazoles, and, specifically, a novel drug Acyzol, which can be used as efficient antidote after poisoning by carbon monoxide and other combustion products

Pharmacological Correction of Hypoxic Conditions by Complexes of Zinc with N-Alkenylimidazoles

© 2016, Springer Science+Business Media New York.The discovery and development of effective antihypoxic drugs is an important issue in modern experimental and clinical pharmacology. Complexes of zinc containing imidazole cycles as ligands are promising candidates for the design of novel drugs, including pharmacotherapeutic tools for patient’s protection under conditions of oxygen deficiency. Herein, we report antihypoxic activity of zinc complexes with N-alkenylimidazoles, and, specifically, a novel drug Acyzol, which can be used as efficient antidote after poisoning by carbon monoxide and other combustion products