Effect Of Surfactant Chain Length Difference In Mixed Surfactant Systems On Self Emulsification Of Poorly Soluble Drug

In the present investigation the effect of chain length difference (Δn) of different surfactant mixtures was evaluated on self emulsifying capability of self emulsifying drug delivery system of aceclofenac. Three surfactants of Tween series namely Tween 20, Tween 40 and Tween 80 were used for the study. The lipid carrier used was almond oil. Surfactant mixtures were prepared by combining Tween 20 and Tween 80 (Δn=6), Tween 20 and Tween 40 (Δn=4), Tween 40 and Tween 80 (Δn=2) in definite proportion. Pseudoternary diagram study was carried out to determine the surfactant mixture which provides the largest microemulsifying region. The pseudoternary diagram study revealed that the microemulsifying region increases as the difference in chain length increases. So, Tween 80 and Tween 20 were selected for formulation development, the proportion of which is further optimized by simplex lattice design. The formulations were prepared and subjected to different evaluation parameters. The optimized formulation has a particle size of 68.95 nm and zeta potential of -15.3 mV

Study of Serum lipid profiles associated with hypertensive patients

Background: High blood pressure is associated with elevated atherogenic blood lipid fractions. A better understanding of the relation between blood pressure and blood lipids may provide insight into the mechanisms of hypertension associated with increased risk of coronary heart disease. Methods: the serum lipid profile of 50 hypertensive patients were studied and compared with healthy controls. The serum lipid profile was studied concerning various clinical profiles like age, gender, incidence, etc. Result: higher number of patients with hypertension were above 40 years of age group. The serum value of total cholesterol (TC), very low-density lipoprotein (VLDL), Low-density lipoprotein (LDL), Total cholesterol (TC)/High-density lipoprotein (HDL), triglycerides (TGL), Low-density lipoprotein LDH/high-density lipoprotein LDH were significant elevated in the hypertensive group as compared to healthy controls. The incidence of hyperlipidemia was more in male patients. Conclusion: there was a significant alteration observed of lipid profiles in hypertensive patients as compared to controls

Serum Lipid Profiles with Patients of Myocardial Infarction (MI)

Background: Serum lipids and lipoproteins are estimated in 50 patients with myocardial infarction (MI). Serum total lipids, total cholesterol (TC), and LDL-cholesterol (LDLc) revealed a significant change in patients with myocardial infarction (MI). TC/HDLc and LDLc/HDLc ratios expressed a substantial increase on a predischarge day compared to the day of admission. Serum triglycerides showed an increasing trend after developing myocardial infarction Aim of the present study is to evaluate the significant change in serum lipid profile in patients with myocardial infarction (MI). Materials and methods: It was a prospective, cross-sectional study conducted in the pathology department and ICU of cardiology, Jaya Arogya Hospital Gwalior Madhya Pradesh state, India focusing on patients admitted with myocardial infarction. The patient's demographic and lipid profile with cardiac events were recorded. Result: In this study, average serum total cholesterol, serum triglycerides, serum high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol estimated in myocardial infarction patients were 202.98±37.87mg/dl, 236.48±41.62mg/dl, 35.84±5.07mg/dl, 124.76±32.23mg/dl respectively. Conclusion: The serum lipid profiles are observed after myocardial infarction. Dyslipidemia is more prevalent in cardiac patients as compared to healthy persons. Elevated low-density lipoprotein cholesterol level, lower level of high-density lipoprotein cholesterol associate with cardiac event