Zoning areas prone to fire occurrences in the forest ecosystems of North Zagros (Case study: Sardasht forests in West Azarbaijan)

The ecological balance in nature is integrated with forest safety. Wildfire causes irreparable effects on the ecological functions of the forest and disrupts the production of oxygen and carbon sequestration, reducing biodiversity, expanding pests and diseases, and eventually breaking the balance of nature, which is the unique role of the forest. The purpose of this study was to identify the factors affecting the occurrence and zoning of fire hazards in Sardasht forests in the area of 1784.8 hectares to achieve control and counteraction strategies. At first, layers of elevation, slope, aspect, precipitation, temperature, organic carbon, soil texture, and vegetation cover were mapped for the study area. AHP was used for prioritization, evaluation criteria, and weighting of the layers. Finally, the classifications of the layer were done using GIS, and hazard scores were classified at four classes included; Safe, low risk, medium risk, and high risk. The results showed that 12.7% of the study area is at high risk, 39.9% has moderate risk, 31.9% is in the low-risk area and 15.5% is located in the safe area. Also, the Angstrom index was showed that wildfire occurring has maximum possibility between June to September. It was also found that the north-east of the study area is more at risk of fire due to the denser vegetation than other areas. The minimum fire hazard was observed in the north, part in the south, and the narrow strip in the central regions of the study area

Effect of Eicosapentaenoic Acid on the Expression of ABCG1 Gene in the Human Monocyte THP-1 Cells

Cardiovascular disease (CVD) is the leading cause of death and disability in developed countries. Atherosclerosis is the major cause of CVD, accounting for about half of the attributed deaths. Cholesterol homeostasis is one of the most important factors in atherosclerosis. ATP-Binding cassette transporters cholesterol. Omega (ω) 3 fatty acids are important ligands for regulation of ABC transporters such as ABCG1. Concern has been raised that the low absolute intakes of EPA and high ratios of ω-6 polyunsaturated fatty acids (ω-6 PUFA) to EPA may predispose some individuals to CVD. Eicosapentaenoic acid (EPA) is the most abundant ω3 fatty acid in the diet. The objective of this study was to evaluate the effect of different concentrations of EPA on the expression of ABCG1 gene in the human monocyte THP-1 cells. In this study, THP-1 cells were cultured in RPMI 1640 medium, THP-1 monocytes were then differentiated to macrophages with PMA (phorbol myristic acid) and stimulated with 50, 75 and 100 μM of EPA for 24 h at 37°C. We examined the effects of EPA treatment on the expression of ABCG1 gene using Quantitative Real time RT-PCR (qRT-PCR). Our results, indicate that ABCG1 mRNA expression was significantly reduced by 50, 75 and 100 μM EPA fatty acid treatments as compared to the control cells (р = 0.009, р < 0.001 and р = 0.002, respectively). These results suggest that polyunsaturated fatty acids (PUFAs) such as EPA have an effect on the cholesterol homeostasis in macrophages, and they can change the expression of ABCG1 gene. It seems that EPA has different effects on gene expression and lipid metabolism