15 research outputs found
Synthesis and calcium channel antagonist activity of new symmetrical and asymmetrical 4-[2-chloro-2-(4-chloro-6-methyl-2-oxo-2H-pyran-3-yl)vinyl]-substituted 1,4-dihydropyridines
No full textNew symmetrical 4-[2-chloro-2-(4-chloro-6-methyl-2-oxo-2H-pyran-3-yl)vinyl]-substituted 1,4-dihydropyridines were synthesized in moderate to good yields via the modified Hantzsch reaction of beta-dicarbonyl compounds with (Z)-3-chloro-3-(4-chloro-6-methyl-2-oxo-2H-pyran-3-yl) acrolein in the presence of an excess amount of NH4OAc. Also, the reaction of beta-dicarbonyl compounds with (Z)-3-chloro-3-(4-chloro-6-methyl-2-oxo-2H-pyran-3-yl)acrolein in the presence of enamino esters and ketones was performed, and asymmetrical 4-[2-chloro-2-(4-chloro-6-methyl-2-oxo-2H-pyran-3-yl)vinyl]-substituted 1,4-dihydropyridines were obtained in moderate to good yields at room temperature. The calcium channel blocking activity of these compounds was assessed. They demonstrated moderate to weak effects, although one compound had a comparable effect (IC50 = 1.40x10(-7) M) with respect to the reference drug Nifedipine
Synthesis of Mono- and Bis-chlorosulfonylarylpyrones and Related Sulfonates and Sulfonamides
No full textNovel ferrocene-based ionic liquid supported on silica nanoparticles as efficient catalyst for synthesis of naphthopyran derivatives
No full textSynthesis of Betti base derivatives catalyzed by nano-CuO-ionic liquid and experimental and quantum chemical studies on corrosion inhibition performance of them
No full textPreparation of new red perylene fluoroionophores containing azacrown and their ionophoric properties
No full textOne-pot synthesis of pyran derivatives using silica-coated magnetic nanoparticles functionalized with piperidinium benzene-1,3-disulfonate as a new efficient reusable catalyst
No full textBoric acid as a mild and efficient catalyst for one-pot synthesis of 1-amidoalkyl-2-naphthols under solvent-free conditions
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