Paradoxical Hypertrichosis after Laser Therapy

OBJECTIVES: In numerous cultures, unwanted hair is considered a common aesthetic problem. For hair removal, the use of lasers is a common medical procedure that is comparatively safe and has few side effects. Paradoxical hypertrichosis has been reported rarely in previous studies. The aim of this study was to find out the frequency of paradoxical hypertrichosis after laser treatment. METHODOLOGY: This cross sectional study was done for a period of one year from January 2020 to January 2021. This study was conducted at Al-Shifa Clinic and Skin Aesthetic, Nowshera, Khyber Pakhtunkhwa.  All those patients who go-through the laser hair removal were included in the study. Diode laser with 808nm wavelength was used. All the patients were observed for paradoxical hypertrichosis after laser treatment.  RESULTS: Total 140 patients underwent laser hair removal during a one-year study. There were 120 females and 20 male in our study. The mean age of male was 28±1.2 while the mean age of females was 26±1.4. Amongst 140 patients, the overall prevalence of paradoxical hypertrichosis after laser treatment was 7.8% (n=11). This side effect was observed dominantly on the neck and face. Skin phototype III and 1V were observed with this side effect. CONCLUSION: Our research study concludes that paradoxical hypertrichosis occurs rarely after laser therapy. Study with high sample size and risk factors should be done for better understanding.&nbsp

An investigation into membrane bound redox carriers involved in energy transduction mechanism in <em>Brevibacterium linens </em>DSM 20158 with unsequenced genome

Brevibacterium linens (B. linens) DSM 20158 with an unsequenced genome can be used as a non-pathogenic model to study features it has in common with other unsequenced pathogens of the same genus on the basis of comparative proteome analysis. The most efficient way to kill a pathogen is to target its energy transduction mechanism. In the present study, we have identified the redox protein complexes involved in the electron transport chain of B. linens DSM 20158 from their clear homology with the shot-gun genome sequenced strain BL2 of B. linens by using the SDS-Polyacrylamide gel electrophoresis coupled with nano LC-MS/MS mass spectrometry. B. linens is found to have a branched electron transport chain (Respiratory chain), in which electrons can enter the respiratory chain either at NADH (Complex I) or at Complex II level or at the cytochrome level. Moreover, we are able to isolate, purify, and characterize the membrane bound Complex II (succinate dehydrogenase), Complex III (menaquinone cytochrome c reductase cytochrome c subunit, Complex IV (cytochrome c oxidase), and Complex V (ATP synthase) of B. linens strain DSM 20158.</p

Adsorption kinetic, equilibrium and thermodynamic studies of eosin-B onto anion exchange membrane

In this research, batch adsorption of anionic dye Eosin-B (EB) onto anion exchange membrane (AEM) (BI) from aqueous solution has been investigated at room temperature. The effect of some operating conditions such as contact time, membrane dosage, initial dye concentration and temperature on the percentage removal of EB from aqueous solution has been investigated in detail. Moreover, adsorption kinetics has been analyzed using different models such as pseudo-first-order, pseudo-second-order, Elovich, liquid film diffusion, modified Freundlich and Bangham models. Results show that adsorption data fits to the pseudo-second order kinetics very well. Non-linear isotherms containing two parameters and three parameters isotherms have been applied on experimental data. Different thermodynamic parameters such as Gibb’s free energy (DG°), enthalpy (DH°), and entropy (DS°) have been calculated, which shows that adsorption of EB onto anion exchange membrane (B1) is an exothermic process.The authors are highly thankful to the CAS-TWAS President's fellowship for PhD financial support.Scopu