Intelligent Algorithm for Efficient Use of Energy Using Tackling the Load Uncertainty Method in Smart Grid

In this paper, i am developing a unique optimization based real time inland load management algorithm that takes into account load ambiguity in order to minimize the energy payment for each residential user, as well as reduce the peak to average ratio to overcome the drawbacks in the stability of electrical grid. By categorizing the all residential load in different classes, i.e. must run, interruptible and uninterruptible appliances, i used the real time pricing scheme for load management. However, real time pricing creates the peak profiles when the energy demand is too high, that’s why i used the combination of real time pricing and inclining blocks rates model to improve the grid stability by reducing the peak to average ratio. A simulation results show that the proposed algorithm efficiently and effectively reduced the overall residential energy cost as well as peak to average ratio of our model for data provided

Semi-leptonic Ds+D_s^+(1968) decays as a scalar meson probe

The unusual multiplet structures associated with the light spin zero mesons have recently attracted a good deal of theoretical attention. Here we discuss some aspects associated with the possibility of getting new experimental information on this topic from semi-leptonic decays of heavy charged mesons into an isosinglet scalar or pseudoscalar plus leptons.Comment: 11 pages, 4 figure

Doubly perturbed S3S_3 neutrinos and the s13s_{13} mixing parameter

We further study a predictive model for the masses and mixing matrix of three Majorana neutrinos. At zeroth order the model yielded degenerate neutrinos and a generalized ``tribimaximal" mixing matrix. At first order the mass splitting was incorporated and the tribimaximal mixing matrix emerged with very small corrections but with a zero value for the parameter $s_{13}$. In the present paper a different, assumed weaker, perturbation is included which gives a non zero value for $s_{13}$ and further corrections to other quantities. These corrections are worked out and their consequences discussed under the simplifying assumption that the conventional CP violation phase vanishes. It is shown that the existing measurements of the parameter $s_{23}$ provide strong bounds on $s_{13}$ in this model.Comment: 8 page

βC1 of chili leaf curl betasatellite is a pathogenicity determinant

<p/> <p>Background</p> <p>Cotton leaf curl disease in the Indian subcontinent is associated with several distinct begomoviruses that interact with a disease-specific DNA satellite named Cotton leaf curl Multan betasatellite (CLCuMB). However, we have recently reported that Chili leaf curl betasatellite (ChLCB) is also occasionally found associated with the disease in Pakistan. The question as to whether ChLCB contributes to the development of disease symptoms such as leaf curling and enations remain to be answered. We have previously shown that the expression of βC1 of CLCuMB develops all symptoms of cotton leaf curl disease in <it>Nicotiana benthamiana </it>when expressed from PVX vector.</p> <p>Findings</p> <p>The role of ChLCB in the induction of typical disease symptoms was studied by its expression from PVX vector in <it>N. benthamiana</it>. The expression of βC1 from PVX vector developed severe leaf curl symptoms and leaf-like enations that resemble the phenotype induced by βC1 of CLCuMB.</p> <p>Conclusions</p> <p>The results presented here show that the expression of βC1 of ChLCB from PVX vector exhibit phenotype typical of cotton leaf curl and therefore ChLCB may contribute to the disease symptoms.</p

Pre-operative intraocular pressure does not influence outcome of trabeculectomy surgery: a retrospective cohort study.

To investigate whether pre-operative intraocular pressure (IOP) predicts outcome of trabeculectomy surgery in patients with primary open angle glaucoma over a 3-year period of follow-up

Immunohistochemical evaluation of small round cell tumors of childhood

Objective: This study was done to evaluate the pediatric undifferentiated small round cell tumors with immunohistochemical staining. Setting: The present study included consecutive cases of small round cell tumors which were diagnosed in children (\u3c15 years) in the section of Histopathology at the Aga Khan University Hospital, Karachi during the period of two years. Methods: The group of undifferentiated small round cell tumors were evaluated immunohistochemically by using a panel of antibodies on sections from routinely processed, formalin fixed, paraffin embedded tissue blocks. Results: The category of undifferentiated small round cell tumors included rhabdomyosarcoma (23.2%), primitive neuroectodermal tumor (17.9%), non-Hodgkin’s lymphoma (16.1%), neuroblastoma (14.2%), Ewing’s sarcoma (10.7%) in order of frequency. Osteosarcoma (Small cell variant), retinoblastoma and medulloblastoma comprised 1.8% each. In seven cases (12.5%), the immunohistochemical analysis was inconclusive. Conclusion: Immunohistochemistry is a very valuable diagnostic tool which helps in distinguishing the undifferentiated tumors especially small round cell tumors. The immunohistochemical staining needs to be performed routinely for undifferentiated tumors in diagnostic histopathology

Functional Genomics Tool: Gene Silencing in \u3ci\u3eIxodes scapularis\u3c/i\u3e Eggs and Nymphs by Electroporated dsRNA

Background Ticks are blood-sucking arthropods responsible for transmitting a wide variety of disease-causing agents, and constitute important public health threats globally. Ixodes scapularis is the primary vector of the Lyme disease agent in the eastern and central U.S. RNAi is a mechanism by which gene-specific double-stranded RNA (dsRNA) triggers degradation of homologous mRNA transcripts. Here, we describe an optimized protocol for effectively suppressing gene expression in the egg and nymphal stages of I. scapularis by electroporation. Results The genes encoding the putative Phospholipase A2 (PLA2), cytoplasmic Cystatin, Syntaxin-5, β-Actin and Calreticulin were targeted by delivering the dsRNA encoding the specific gene coding regions in the unfed nymphs. Silencing was measured using real time qRT-PCR. Electroporation as a mode of dsRNA delivery appears to be substantially efficient and less traumatic to the tick than dsRNA microinjection in the unfed nymphs. Using Cy3-labeled dsRNA to monitor the movement, electroporated dsRNA entered the nymphs and spread to salivary glands and other tissues. The significant disruption of β-actin and cytoplasmic Cystatin transcripts in tick eggs demonstrate the applicability of this technique. The PLA2, cytoplasmic Cystatin, Syntaxin-5, β-Actin and Calreticulin genes were also significantly silenced, suggesting that this method has the potential to introduce dsRNA in eggs and unfed nymphs. Conclusions Our study demonstrates that electroporation can be used as a simple dsRNA delivery tool in assessing the functional role of tick genes in the vector-host interactions. This technique represents a novel approach for specific gene suppression in immature stages of ticks