Leigh syndrome: A rare mitochondrial disorder

Leigh syndrome is a rare, mitochondrial disorder of childhood . In most cases dysfunction of the respiratory chain enzymes is responsible for the disease. Raised lactate levels in blood and/or cerebrospinal fluid is noted. Magnetic resonance imaging showing characteristic symmetrical necrotic lesions in the basal ganglia and/or brain stem that leads to the  appropriate diagnosis. Here, we report a case of progressive neurologic disorders presenting with motor and intellectual regression which on MRI was diagnosed as Leigh syndrome

Leigh syndrome: A rare mitochondrial disorder

Leigh syndrome is a rare, mitochondrial disorder of childhood . In most cases dysfunction of the respiratory chain enzymes is responsible for the disease. Raised lactate levels in blood and/or cerebrospinal fluid is noted. Magnetic resonance imaging showing characteristic symmetrical necrotic lesions in the basal ganglia and/or brain stem that leads to the  appropriate diagnosis. Here, we report a case of progressive neurologic disorders presenting with motor and intellectual regression which on MRI was diagnosed as Leigh syndrome

Clinical and radio-angiographic features of paediatric moyamoya disease in Bangladesh

Background: Moyamoya disease is a cerebrovascular arteriopathy of unknown origin characterized by progressive stenosis followed by occlusion of the cerebral arteries. Studies on moyamoya disease, especially in children in Bangladesh, are rare. We aimed to determine the clinical and neuroimaging features of moyamoya disease, particularly angiographic features. Methods: Forty children diagnosed with moyamoya disease were consecutively recruited from Bangabandhu Sheikh Mujib Medical University Hospital, Dhaka, Bangladesh. Each patient underwent a medical history and physical examination focusing on stroke, magnetic resonance imaging, and magnetic resonance angiography scans of the brain. In some instances, electroencephalogram and digital subtraction angiography were also performed. Results: Of the 40 patients, 22 experienced their first-ever stroke (median age, 84 months), and 18 had recurrent strokes (median age, 90 months). Common symptoms included hemiparesis, headache, seizure, and speech disorder. The commonly affected vessels were the internal carotid and middle cerebral arteries. Cortical involvement was found in 82.5% of cases. Bilateral involvement was observed in 37.5% of the patients, most of whom were in the Suzuki stage III. Conclusion: Hemiparesis, headache, seizure, and speech disorder were the common manifestations. Most patients reported late (Suzuki stages III and IV), indicating an advanced stage.  Early detection is necessary, considering the severity of the disease and its inherent tendency for recurrence.  

RELATIONSHIP BETWEEN METROLOGICAL PARAMETERS AND VECTOR BORNE DENGUE DISEASE USING ONCOLOGICAL FRACTAL TREATMENT

Dengue is the most vital arboviral disease in humans, which is occurring in tropical and subtropical areas around the world. Dengue fever is itemized as an urban human disease as it spreads easily to urban environmental/ morphological contexts because of the uneven increase of urban population and infectious diseases as a result of climate change. Dengue epidemic cases related to climatic parameters are helpful to monitor and prevent the transmission of dengue fever. Many studies have focused on describing the clinical aspects of dengue outbreak. We bring out the epidemiological study to investigate the dengue fever development and prediction in the Karachi city. This study described the oncological treatment by statistical analysis and fractal rescaled range (R/S) method of the dengue epidemics from January 2001 to December 2020, based on the urban morphological patterns, and climatic variables including temperature and ENSO respectively. The R/S method in oncologists has been carried in two ways, basic oncological/statistical analysis and Fractal dimension adapt to the study the nature of the subtleties of dengue epidemic data, another showing the dynamics of oncological process. Climate parameters are shown that the fractal dimension value revealed a persistency behavior i.e. time series is an increasing, Fractal analysis also confirmed the anti-persistent behavior of dengue for months of September to November and the normality tests specified the robust indication of the intricacy of data. This study will be useful for future researchers working on epidemiology and urban environmental oncological fields to improve and rectify the urban infectious diseases

Effective bioconversion of locally obtained apple waste into citric acid using aspergillus niger (NRRL 567)

A viable and sustainable method was used to produce citric acid. Apple waste (pomace) was used as a substrate and displayed a good efficiency for citric acid yield. The fermentation process was carried out using Aspergillus Niger (NRRL 567) strain. This fungal strain showed a competent performance in fermenting apple waste to produce citric acid. Various key parameters were analyzed and optimized such as incubation temperature, amount of substrate, ph, moisture content, nitrogen source, metal ions, methanol inducer and inoculum density. Among such parameters, the highest citric acid yield of 158 g/kg of apple pomace was achieved with the use of methanol inducer. Methanol inducer, moisture content, amount of substrate and nitrogen source were found to have significant impact on CA production. The fungal strain used in the present study is known to possess an impressive biomass fermentation capacity, as also demonstrated by the present work. In Pakistan, this strain has not been analyzed for its efficiency to produce citric acid using pomace of locally cultivated apple, hence the novelty of the present work. All the experimental work, analysis and optimization was accomplished on laboratory scale at Advanced Research Laboratory, Zoology Department, GC University, Faisalabad, Pakistan

A STUDY OF LONG-TERM SUNSPOTS AND K-INDEX GEOMETRIC CYCLES USING PROBABILISTIC MODELING

The research work done in this paper comprises the application of different well-known probability distribution models. This includes the understanding of the behavior and dynamics of 24 sunspot cycles with total data. The time-series data sets were selected from 1749 to 2014. To observe the solar activity effects on K-index activity the double cycles from 1932 to 2014 were also incorporated in the study. The comparative study is useful to observe the long-term solar-terrestrial connection. The magnetic field of the sun reverses its polarity after every 11 years of the cycle. So after every 22 years, the north pole becomes again north pole. By using the two well-known tests Kolmogorov-Smirnov (KST) and Anderson-Darling test (ADT) the probability distribution models were obtained for each sunspot cycles and compare. The significant probability models for all the sunspot cycles have been obtained. The fitted probability distribution models on selected data sets may be useful to understand the trend of solar and geomagnetic activity

Does green entrepreneurial behavior enhance through entrepreneurship education, perceivedability to use technology, and commitment to environment? Understanding the contribution of entrepreneurial motivation and university support

In a time of environmental destruction, global warming, and continuous rise in the earth’s temperature, Green Entrepreneurship has emerged as a potential solution through which ecological, economic, and social sustainability can be attained. Hence the current is operationalized in order to understand the contribution of Entrepreneurial Motivation (MOT) and University Support (SUP) in enhancing Green Entrepreneurial Behavior (BEH) powered by Entrepreneurship Education (EDU), Perceived-ability to use Technology (TEC), and Commitment to Environment (CMT). On the dataset of 487 students from Chinese education institutions, the application of PLS-SEM reported significant and positive associations among the proposed hypotheses. Precisely, EDU, TEC, and CMT are reported to enhance the level of SUP, MOT, and BEH, whereas the role of SUP and MOT in enhancing BEH is also reported. Based on the findings, there are different managerial implications that the current study has proposed

Plant-Based Alternative Treatment for Leishmaniasis: A Neglected Tropical Disease

Leishmaniasis is a third most important vector born disease caused by intracellular parasite belongs to genus Leishmania. The leishmaniasis is prevalent in 102 countries/areas worldwide. Approximately, it effected 350 million people worldwide. Leishmaniasis effects developing and undeveloped countries globally. Antileishmanial drugs (pentavalent antimonials, stibogluconate, miltefosine, paramycin, and amphotericin) are most vital tool for curing leishmaniasis. However, none of these drugs is free from side effect including cost, toxicity, drug resistance, administration route, and prolong time, these disadvantages are main obstacle in the Leishmania infection eradication. Considering the increasing cases of leishmaniasis and drug resistance there is an urgent need for an effective and novel approach against leishmaniasis. Therefore, many researchers have tried to develop new medicines for the treatment of Leishmania infection. In the course of new therapies identification, plant based compounds were found to be an alternative that can be either used directly or with structural modifications. Several plants have been known for ages to be the source of phytochemicals with high values of medicines. These phytochemicals have been extracted by various techniques and have shown efficacy for the curing of several diseases. This chapter study explain various applications based on green approaches drugs for the treatment of leishmaniasis

Known risk factors and co-morbidities in 100 cases of cerebral palsy in a neu­rology follow-up clinic

Background: Cerebral palsy (CP) is a major cause of crippling in children. Several antenatal, natal and post natal factors for CP like birth asphyxia and pretenn & LBW deliveries were identified.Objective: To see the presence of known risk factors of CP and co-morbidities in our setting. Methods: ln this study 100 cases of cerebral palsy attending the child neurology out-patient department Bangabandhu Sheikh Mujib Medical University (BSMMU) were evaluated with special attention to risk factors of CP. Full evaluation was done to find out co-morbidities. Results: Birth asphyxia (49%) was the most common risk factor. Mental retardation; speech problem and seizure were common co-morbidities. Conclusion: As birth asphyxia is common risk factor of cerebral palsy, it may be reduced by improving perinatal care

Known risk factors and co-morbidities in 100 cases of cerebral palsy in a neu­rology follow-up clinic

Background: Cerebral palsy (CP) is a major cause of crippling in children. Several antenatal, natal and post natal factors for CP like birth asphyxia and pretenn & LBW deliveries were identified.Objective: To see the presence of known risk factors of CP and co-morbidities in our setting. Methods: ln this study 100 cases of cerebral palsy attending the child neurology out-patient department Bangabandhu Sheikh Mujib Medical University (BSMMU) were evaluated with special attention to risk factors of CP. Full evaluation was done to find out co-morbidities. Results: Birth asphyxia (49%) was the most common risk factor. Mental retardation; speech problem and seizure were common co-morbidities. Conclusion: As birth asphyxia is common risk factor of cerebral palsy, it may be reduced by improving perinatal care