9,9-Bis[4-(prop-2-yn­yloxy)phen­yl]-9H-fluorene

In the title compound, C31H22O2, the bond angle at the C atom belonging to the five-membered ring of the fluorene system is opened to 112.64 (12)°. The two benzene rings are twisted with respect to the fluorene ring system at dihedral angles of 72.81 (6) and 81.83 (6)°. One Car­yl—O—C—C  fragment is extended, with a C—O—C—C torsion angle of −178.77 (13)°, but the other Car­yl—O—C—C  fragment is bent, with a C—O—C—C torsion angle of 64.78 (19)°. Inter­molecular weak C—H⋯O hydrogen bonding is present in the crystal structure

Improving Palliative Care with Deep Learning

Improving the quality of end-of-life care for hospitalized patients is a priority for healthcare organizations. Studies have shown that physicians tend to over-estimate prognoses, which in combination with treatment inertia results in a mismatch between patients wishes and actual care at the end of life. We describe a method to address this problem using Deep Learning and Electronic Health Record (EHR) data, which is currently being piloted, with Institutional Review Board approval, at an academic medical center. The EHR data of admitted patients are automatically evaluated by an algorithm, which brings patients who are likely to benefit from palliative care services to the attention of the Palliative Care team. The algorithm is a Deep Neural Network trained on the EHR data from previous years, to predict all-cause 3-12 month mortality of patients as a proxy for patients that could benefit from palliative care. Our predictions enable the Palliative Care team to take a proactive approach in reaching out to such patients, rather than relying on referrals from treating physicians, or conduct time consuming chart reviews of all patients. We also present a novel interpretation technique which we use to provide explanations of the model's predictions.Comment: IEEE International Conference on Bioinformatics and Biomedicine 201

Workplace Violence in Medical Radiation Science: A Systematic Review

Introduction According to World Health Organization (WHO), workplace violence (WPV) is a significant issue in healthcare. However, no systematic review on WPV in medical radiation science (MRS) has been published yet. The purpose of this paper is to systematically review prevalence of WPV in MRS and its risk factors. Methods Electronic scholarly publication databases, namely EBSCOhost/Cumulative Index of Nursing and Allied Health Literature Ultimate, PubMed/Medline, ScienceDirect, Scopus, and Wiley Online Library were used for literature search to identify articles about WPV in MRS published over last 10 years as per preferred reporting items for systematic reviews and meta-analyses guidelines. To facilitate comparisons of the WPV prevalence and relative importance of individual risk factors across the included studies, their reported absolute figures of findings were used to synthesize respective percentages (if not stated). Results Twelve papers met the selection criteria and were included. This review shows that the WPV prevalence were 69.2–100 % (whole career) and 46.1–83.0 % (last 12 months) in diagnostic radiography, 63.0–84.0 % (whole career) in radiation therapy, 57.6 % in medical sonography (last 12 months), and 46.8 % (last 6 months) in nuclear medicine. The identified WPV risk factors included intoxicated patients, staff stress, feeling of inadequacy resulting in self-protection, more vulnerable practitioners (female, <40 years old and <5-year experience), working in radiation therapy treatment room, emergency department, examination room, general radiography, public hospital, and non-examination and waiting areas, long patient waiting time, night shift, overcrowding environment, unable to meet patients'/family members' expectations, miscommunication, patient handling, inadequate staff and security measures, interaction with colleagues, and lone working. Conclusion The WPV risk in diagnostic radiography and radiation therapy appears extremely high as a result of the aforementioned risk factors. Nevertheless, these study findings should be used with caution due to potential non-response bias. Implications for practice A WPV policy should be developed in every clinical workplace. Even if such policy is available, its enforcement including policy awareness boosting, and encouraging incident reporting and support seeking will be essential for reducing WPV. More survey studies based on WHO WPV questionnaire should be conducted for strengthening evidence base

(Butane-1,3-diyne-1,4-diyl)bis­(tri­isopropyl­silane)

The mol­ecule of the title compound, C22H42Si2, lies on a center of inversion, and the triisopropyl­silyl groups are staggered

9,9-Bis[4-(2-chloro­eth­oxy)phen­yl]-9H-fluorene

The title compound, C29H24Cl2O2, a fluorene derivative, features a C atom that is connected to four phenyl­ene rings, two of which are almost coplanar (r.m.s. deviation = 0.035 Å) as they belong to the fluorene system. The other two rings are aligned at angles of 67.5 (5) and 85.5 (5)° with respect to the pair. The O and Cl atoms of the –OCH2CH2Cl– units adopt a gauche conformation [torsion angles = 61.6 (6) and 66.6 (5)°]

3-Nitro­phenyl pyrimidin-2-yl ether

In the title compound, C10H7N3O3, the dihedral angle between the two aromatic rings is 87.5 (1) Å; their ipso-C atoms subtend an angle of 117.4 (1)° at the ether O atom

2-(p-Tol­yloxy)pyrimidine

In the title compound, C11H10N2O, the aromatic rings make a dihedral angle of 76.3 (1)°. The C—O—C angle at the ether atom is widened to 117.79 (9)°