Synthesis and antibacterial evaluation of novel heterocycles from 5-chloro-3-methyl-1-phenylpyrazole-4-carbaldehyde

910-9175-Chloro-3-methyl-1-phenylpyrazole-4-carbaldehyde 1 reacts with acetylpyrone 2 and acetylbenzopyrone 3 via Claisen-Schmidt condensation to afford heterochalcones 4a,b which undergo facile cyclisation with hydrazines to give 3,5-heteroaryl-2-pyrazolines 5a-d in quantitative yield. Further, heterochalcones 4a,b undergo addition reaction using Br2/MeOH in the presence of Pb(NO3)2 or AgNO3 to afford addition products 6a,b. The structures of the newly synthesized compounds have been established on the basis of their spectral studies. The newly synthesized heterochalcones and pyrazolines have been screened for their antibacterial activity against two kinds of strains using the Agar well diffusion method. Some of the compounds showed significant activity against both the strains

Thermal solvent-free synthesis of chromonyl chalcones, pyrazolines and their in vitro antibacterial, antifungal activities

A facile and ecofriendly synthesis of new chromonyl chalcones 3a-b from 3-formylchromone 1 and active methyl compounds 2a-b is reported under thermal solvent-free heating condition in good yields. The chromonyl chalcones 3a-b were used as intermediates under green condition for the synthesis of new bioactive pyrazoline derivatives 4a-f. The compounds were tested for antimicrobial activity by disk diffusion assay with slight modifications against Gram-positive, Gram-negative strains of bacteria as well as fungal strains. The investigation of antimicrobial screening revealed that compounds 3a-b and 4a-f showed antibacterial and antifungal activities

Thermal solvent-free synthesis of chromonyl chalcones, pyrazolines and their in vitro

A facile and ecofriendly synthesis of new chromonyl chalcones 3a-b from 3-formylchromone 1 and active methyl compounds 2a-b is reported under thermal solvent-free heating condition in good yields. The chromonyl chalcones 3a-b were used as intermediates under green condition for the synthesis of new bioactive pyrazoline derivatives 4a-f. The compounds were tested for antimicrobial activity by disk diffusion assay with slight modifications against Gram-positive, Gram-negative strains of bacteria as well as fungal strains. The investigation of antimicrobial screening revealed that compounds 3a-b and 4a-f showed antibacterial and antifungal activities