Assessed adverse events among the four treatment arms during a randomized, placebo-controlled trial carried out on Pemba Island, Tanzania.

<p>Adverse events were assessed at five different time points (before treatment, 3 and 24 hours after first treatment, and 3 and 24 hours after second treatment). Nitazoxanide was given on the first day of treatment, while albendazole was given on the second day of treatment.</p>*<p>statistically significant more adverse events in nitazoxanide-treated children compared to children receiving placebo.</p>a<p>One of these adverse events was classified as moderate.</p

Baseline characteristics of school-aged children included in the trial.

a<p>684 datasets.</p>b<p>683 datasets.</p>*<p>all infections with hookworms were classified as light.</p

Effect of albendazole, nitazoxanide, sequentially administered albendazole-nitazoxanide combination, and placebo against soil-transmitted helminths.

<p>Effect of different treatments calculated with the per-protocol analysis.</p>*<p>95% CI of egg reduction rates were calculated using bootstrap resampling.</p

True cure rates (True) and cure rates based on a single (KK1) duplicate (KK2), quadruplicate Kato-Katz (KK4) and FECPAK^G2 (FP) against hookworm and <i>T</i>. <i>trichiura</i> for the four different treatment arms.

<p>Cure rates against <i>A</i>. <i>lumbricoides</i> are not presented.</p

Prevalence and intensity (mean eggs per gram of stool, EPG) of soil-transmitted helminth infections at D₁ with Kato-Katz and Mini-FLOTAC.

<p>“Gold” standard: combined positive resulted from Kato-Katz and Mini-FLOTAC methods</p><p>Prevalence and intensity (mean eggs per gram of stool, EPG) of soil-transmitted helminth infections at D₁ with Kato-Katz and Mini-FLOTAC.</p

Study flow of stool samples collection and analysis using the single, duplicate, quadruplicate Kato-Katz and FECPAK^G2.

<p>Study flow of stool samples collection and analysis using the single, duplicate, quadruplicate Kato-Katz and FECPAK^G2.</p

The estimated sensitivity of FECPAK^G2 based on the infection intensity.

<p>The estimated sensitivity of FECPAK^G2 based on the infection intensity.</p

Class of soil-transmitted helminth infection intensity over time for each child using the Mini-FLOTAC technique.

<p>Red lines: class of infection: <i>A</i>. <i>lumbricoides</i>:< 5000 light, 5000–50000 moderate, >50000 heavy; <i>T</i>. <i>trichiura</i>: < 1000 light, 1000–10000 moderate, >10000 heavy; Hookworm:< 2000 light, 2000–4000 moderate, >4000 heavy.</p

Prevalence of <i>A</i>. <i>lumbricoides</i>, <i>T</i>. <i>trichiura</i>, and hookworm over time with Mini-FLOTAC technique.

<p>KK D: Kato-Katz day 1, MF: Mini-FLOTAC.</p

Sensitivity of the techniques from D1 until D31.

<p>* Significantly different from the ‘gold’ standard; p < 0.05</p><p>KK: Kato-Katz, MF: Mini-FLOTAC; D: day</p><p>Sensitivity of the techniques from D1 until D31.</p