7 research outputs found
Woven Coronary Artery Disease Successfully Managed with Percutaneous Coronary Intervention: A New Case Report.
Woven coronary artery is relatively rare and can be complicated in both acute and chronic phases. A few case reports have been published until now. Herein we report a case with right woven coronary artery managed with drug-eluted stent implantation without complication
Association between parathyroid hormone levels and the extensiveness of coronary artery disease
Objective: Previous studies have suggested that there is a relationship
between coronary artery disease (CAD) and parathyroid hormone (PTH)
levels. Here, we aimed to evaluate the association between PTH levels
and severity of CAD.
Methods: Patients were divided into two groups based on their serum PTH
values. Patients with PTH levels = 72 pg/mL were accepted as Group 1
(n=568) and >72 pg/mL as Group 2 (n=87). Gensini score system and > 50\%
stenosis in any coronary artery with conventional coronary angiography
were used to determine the extensiveness of CAD. This study was designed
as a prospective and cross-sectional study.
Results: Baseline characteristics except for age, gender, and blood
pressure were similar between groups. Mean serum PTH levels of the
entire cohort was 43.4 +/- 29.5 pg/mL. Median Gensini score was 19.5 in
Group 1 and 14.5 in Group 2 (p=0.75). On the other hand, PTH levels were
weakly correlated with Gensini score (Spearman's Rho=0.11, p=0.003).
Additionally, we did not observe a statistically significant difference
between PTH levels and the number of stenotic vessels (p=0.14). This
study was designed as a prospective and cross-sectional study.
Conclusion: There is no association between serum PTH levels and
extensiveness of CAD
Higher ultrafiltration rate is associated with right ventricular mechanical dispersion
Objective: Ultrafiltration rate is one of the major determinants of
adverse outcomes in patients undergoing hemodialysis (HD) therapy.
Previous studies have focused on the impact of HD on right ventricular
(RV) peak strain values. However, the influence of HD on the temporal
characteristics of deformation has not been reported yet. The aim of the
present study was to evaluate the impact of high ultrafiltration rate
(HUR) on RV mechanical dyssynchrony.
Methods: Echocardiographic images focused on the RV and left ventricle
(LV) were obtained from 60 patients (49.2 +/- 17.3 years, 22 female)
before and after HD. Patients were divided into two groups according to
ultrafiltration rate. Changes in echocardiographic parameters with HD
were examined. Two-dimensional speckle-tracking strain analysis was used
to assess deformation. Mechanical dispersion was measured as the
standard deviation of time to peak longitudinal strain of six segments
for RV and 18 segments for LV.
Results: The average ultrafiltrated volume and ultrafiltration rate were
3000.1 +/- 1007.9 mL and 11.4 +/- 2.9 mLkg/h, respectively. Global
longitudinal strain (GLS) of the RV and LV decreased after HD in both
groups. A significant difference was observed in RV mechanical
dispersion with HD for patients in the high ultrafiltration group. A
mild statistically insignificant increase in LV mechanical dispersion
was also observed after HD.
Conclusion: HUR has a substantial impact on LV and RV GLS and RV
dyssynchrony. Ultrafiltration rates and volumes should be kept as low as
possible to achieve hemodynamic stability and tolerability
Association of rs10757274 and rs2383206 Polymorphisms on 9p21 locus with Coronary Artery Disease in Turkish Population
Background and Objectives: Genetic predisposition is an important risk
factor for coronary artery disease (CAD). In this study, we aimed to
evaluate the impact of rs10757274 and rs2383206 polymorphisms in
chromosome 9p21 on presence and severity of CAD in a Turkish population.
Subjects and Methods: A total of 646 patients who underwent coronary
angiography were included in this study. Coronary vessel score and
Gensini score were calculated to assess the angiographic severity of
CAD. Alleles of AA, AG, and GG were determined for rs10757274
(polymorphism-1) and rs2383206 (polymorphism-2) polymorphisms located in
chromosome 9p21 from the blood samples.
Results: There was a significant difference between the alleles in
polymorphism-1 in the presence of coronary artery disease (38.9\% in AA,
48.0\% in GG and 56.4\% in AG, p=0.017). However, there was no
difference between the alleles in polymorphism-2. According to vessel
scores, there was a significant difference between the alleles in
polymorphism-1 (AA 0.71 +/- 1.04, GG 0.88 +/- 1.07, AG 1.06 +/- 1.12,
p=0.018). In polymorphism-2, vessel scores did not show a difference
between the alleles. In polymorphism-1, there was a significant
difference in Gensini score (p=0.041). Gensini scores did not differ
between the alleles in polymorphism-2 (p>0.05 for all). In multivariate
analyses, none of the alleles was an independent factor for presence of
CAD.
Conclusion: The presence of rs10757274 polymorphism including AG allele
in chromosome 9p21 was related to CAD. However, this relationship was
not independent of other cardiovascular risk factors