Phase B: Community Outreach

Initial goal: to collect data to facilitate the 20 I 0 G EH LI class in determining the degree of success of the eight community outreach projects in preparation for Phase 2 of team projects. Evolving goal: to present an evaluation of the GEHLI project process and its possible effect on the success of the institute

Fully differential W' production and decay at next-to-leading order in QCD

We present the fully differential production and decay of a W' boson, with arbitrary vector and axial-vector couplings, to any final state at next-to-leading order in QCD. We demonstrate a complete factorization of couplings at next-to-leading order in both the partial width of the W' boson, and in the full two-to-two cross section. We provide numerical predictions for the contribution of a W' boson to single-top-quark production, and separate results based on whether the mass of the right-handed neutrino (nu_R) is light enough for the leptonic decay channel to be open. The single-top-quark analysis will allow for an improved direct W' mass limit of 525-550 GeV using data from run I of the Fermilab Tevatron. We propose a modified tolerance method for estimating parton distribution function uncertainties in cross sections.Comment: 23 pages, revtex3, 13 ps fig

Definition and Calculation of Bottom Quark Cross-Sections in Deep-inelastic Scattering at HERA and Determination of their Uncertainties

The uncertainties involved in the calculation of bottom quark cross-sections in deep-inelastic scattering at HERA are studied in different phase space regions. Besides the inclusive bottom quark cross-section, definitions closer to the detector acceptance requiring at least one high energetic muon from the semi-leptonic \bquark decay or a jet with high transverse energy are investigated. For each case the uncertainties due to the choice of the renormalisation and factorisation scale as well as the \bquark mass are estimated in the perturbative NLO QCD calculation and furthermore uncertainties in the fragmenation of the bottom quark to a B-meson and in its semi-leptonic decay are discussed

Searching for R-Parity Violation at Run-II of the Tevatron

We present an outlook for possible discovery of supersymmetry with broken R-parity at Run II of the Tevatron. We first present a review of the literature and an update of the experimental bounds. In turn we then discuss the following processes: 1. Resonant slepton production followed by R-parity violating decay, (a) via $LQD^c$ and (b) via $LLE^c$. 2. How to distinguish resonant slepton production from $Z'$ or $W'$ production. 3. Resonant slepton production followed by the decay to neutralino LSP, which decays via $LQD^c$. 4. Resonant stop production followed by the decay to a chargino, which cascades to the neutralino LSP. 5. Gluino pair production followed by the cascade decay to charm squarks which decay directly via $L_1Q_2D^c_1$. 6. Squark pair production followed by the cascade decay to the neutralino LSP which decays via $L_1Q_2D^c_1$. 7. MSSM pair production followed by the cascade decay to the LSP which decays (a) via $LLE^c$, (b) via $LQD^c$, and (c) via $U^cD^cD^c$, respectively. 8. Top quark and top squark decays in spontaneous R-parity violation.Comment: 39 pages, 51 figures, LaTex, reqires aipproc2.sty and axodraw.sty. To be published in the Physics at Run II Workshop: Supersymmetry/Higgs. Text has been edited by H. Dreiner. Author list on front page has been correcte

Why honey is effective as a medicine. 1. Its use in modern medicine

Honey has been used as a medicine for thousands of years and its curative properties are well documented. However, modern medicine turned its back on honey and it is only now, with the advent of multi-resistant bacteria, that the antibiotic properties of honey are being rediscovered

SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer

Pancreatic cancer has a devastating prognosis, with an overall 5-year survival rate of ~8%, restricted treatment options and characteristic molecular heterogeneity. SerpinB2 expression, particularly in the stromal compartment, is associated with reduced metastasis and prolonged survival in pancreatic ductal adenocarcinoma (PDAC) and our genomic analysis revealed that SERPINB2 is frequently deleted in PDAC. We show that SerpinB2 is required by stromal cells for normal collagen remodelling in vitro, regulating fibroblast interaction and engagement with collagen in the contracting matrix. In a pancreatic cancer allograft model, co-injection of PDAC cancer cells and SerpinB2(-/-) mouse embryonic fibroblasts (MEFs) resulted in increased tumour growth, aberrant remodelling of the extracellular matrix (ECM) and increased local invasion from the primary tumour. These tumours also displayed elevated proteolytic activity of the primary biochemical target of SerpinB2-urokinase plasminogen activator (uPA). In a large cohort of patients with resected PDAC, we show that increasing uPA mRNA expression was significantly associated with poorer survival following pancreatectomy. This study establishes a novel role for SerpinB2 in the stromal compartment in PDAC invasion through regulation of stromal remodelling and highlights the SerpinB2/uPA axis for further investigation as a potential therapeutic target in pancreatic cancer

Letter processing and font information during reading: beyond distinctiveness, where vision meets design

Letter identification is a critical front end of the reading process. In general, conceptualizations of the identification process have emphasized arbitrary sets of distinctive features. However, a richer view of letter processing incorporates principles from the field of type design, including an emphasis on uniformities across letters within a font. The importance of uniformities is supported by a small body of research indicating that consistency of font increases letter identification efficiency. We review design concepts and the relevant literature, with the goal of stimulating further thinking about letter processing during reading

Ernst Freund as Precursor of the Rational Study of Corporate Law

Gindis, David, Ernst Freund as Precursor of the Rational Study of Corporate Law (October 27, 2017). Journal of Institutional Economics, Forthcoming. Available at SSRN: https://ssrn.com/abstract=2905547, doi: https://dx.doi.org/10.2139/ssrn.2905547The rise of large business corporations in the late 19th century compelled many American observers to admit that the nature of the corporation had yet to be understood. Published in this context, Ernst Freund's little-known The Legal Nature of Corporations (1897) was an original attempt to come to terms with a new legal and economic reality. But it can also be described, to paraphrase Oliver Wendell Holmes, as the earliest example of the rational study of corporate law. The paper shows that Freund had the intuitions of an institutional economist, and engaged in what today would be called comparative institutional analysis. Remarkably, his argument that the corporate form secures property against insider defection and against outsiders anticipated recent work on entity shielding and capital lock-in, and can be read as an early contribution to what today would be called the theory of the firm.Peer reviewe

D* Production in Deep Inelastic Scattering at HERA

This paper presents measurements of D^{*\pm} production in deep inelastic scattering from collisions between 27.5 GeV positrons and 820 GeV protons. The data have been taken with the ZEUS detector at HERA. The decay channel $D^{*+}\to (D^0 \to K^- \pi^+) \pi^+$ (+ c.c.) has been used in the study. The $e^+p$ cross section for inclusive D^{*\pm} production with $5<Q^2<100 GeV^2$ and $y<0.7$ is 5.3 \pms 1.0 \pms 0.8 nb in the kinematic region {$1.3<p_T(D^{*\pm})<9.0$ GeV and $| \eta(D^{*\pm}) |<1.5$}. Differential cross sections as functions of p_T(D^{*\pm}), $\eta(D^{*\pm}), W$ and $Q^2$ are compared with next-to-leading order QCD calculations based on the photon-gluon fusion production mechanism. After an extrapolation of the cross section to the full kinematic region in p_T(D^{*\pm}) and $\eta$(D^{*\pm}), the charm contribution $F_2^{c\bar{c}}(x,Q^2)$ to the proton structure function is determined for Bjorken $x$ between 2 $\cdot$ 10$^{-4}$ and 5 $\cdot$ 10$^{-3}$.Comment: 17 pages including 4 figure

Tumour-targeted nanomedicines: principles and practice

Drug targeting systems are nanometre-sized carrier materials designed for improving the biodistribution of systemically applied (chemo)therapeutics. Various different tumour-targeted nanomedicines have been evaluated over the years, and clear evidence is currently available for substantial improvement of the therapeutic index of anticancer agents. Here, we briefly summarise the most important targeting systems and strategies, and discuss recent advances and future directions in the development of tumour-targeted nanomedicines