The influence of insulin resistance on total renin level in polycystic ovary syndrome

Purpose of this study is to determine the influence of insulin resistance on total renin with polycystic ovary syndrome (PCOS). Clinical, ultrasonographic and hormonal findings were used to define PCOS. Insulin resistance was estimated by the continuous infusion of glucose with model assessment (CIGMA) in early follicular phase. The sensitivity and specificity of the serum total renin level to diagnose women with PCOS were calculated as 80% and 71.4%, respectively. Serum total renin level which is independent from insulin resistance can be used as a diagnostic marker in normotensive women with PCOS

Results of the ACTH stimulation test in hirsute women

OBJECTIVE: To determine the incidence of late-onset congenital adrenal hyperplasia (LOCAH) due to 21-hydroxylase deficiency among hirsute women and to evaluate the results of the ACTH stimulation test with the clinical characteristics

Mammographic changes in women receiving tibolone therapy

Objective: To investigate the effects of tibolone therapy for menopausal symptoms on mammographic findings and to identify any association between mammographic changes and the demographic and hormonal characteristics of women receiving tibolone

Influence of insulin resistance on total renin level in normotensive women with polycystic ovary syndrome

Objective: To evaluate the influence of insulin resistance on the plasma total renin level in normotensive women with polycystic ovary syndrome (PCOS)

Mammographic density increase in women receiving different hormone replacement regimens

Objective: we investigated effects of different regimens of hormone replacement therapy (HRT) on mammographic density. Methods: ninety-five postmenopausal women, who were on different HRT regimens and completed their 4-year mammographic follow-up. were included into this retrospective and comparative study. Twenty-three of these women, who had surgical menopause, received conjugated equine estrogens (CEE) (Group 1) only. 26 of them received CEE and continuous medroxyprogesterone acetate (MPA) (Group II). 21 women received CEE and cyclic MPA (Group III). and the remaining 25 women received tibolone (Group IV) therapy, Before commencing on HRT, a baseline high-resolution mammography was performed, and repeated at 6-12-month intervals during the period of 4-year follow-up. All mammographies were evaluated according to the Wolfe classification. Results: a diffuse increase in mammographic density was detected in five women (22%) in group 1. nine women (35%) in group II. four women (19%,) in group III, and two women in group IV. The increase in mammographic density was more common among women in group Il than those in the other three groups. However. a statistically significant difference was found only between groups II and IV, Conclusions: different HRT regimens have different effects on breast parenchymal density on mammography. Continuous combination HRT may be more commonly associated with an increase in breast density than other forms of HRT. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved