The Relationship Between Prognosis and Plasma Cell Percentage; Infiltration Pattern, Fibrosis and Microvascular Density in Bone Marrow Biopsies of Plasma Cell Myeloma Patients br

Plasma cell myeloma is a monoclonal disease characterized by anemia, monoclonal protein in serum and or urine, osteolytic in bones, hypercalcemia, and renal failure. The study aims to evaluate the percentage of plasma cells in bone marro , the of bone marro involvement, the intensity of fibrosis and angiogenesis in bone marro , and to assess their relationship ith prognostic markers. In this study, bone marro biopsies of 135 plasma cell myeloma cases ere re-evaluated regarding plasma cell percentage and the pattern of bone marro involvement. Fibrosis as assessed in 132 cases ith reticulin staining and vessel density (M D) in 51 cases ith CD34 staining. The relation of these morphological parameters ith stage and survival lesions pattern clinical as analyzed. Plasma cell percentage, involvement pattern and micro-vessel density sho ed statistically significant micro -status correlation ith stage, hile bone marro fibrosis as not significantly correlated (p 0.05, p 0.001, p 0.011, p 0.05, respectively). percentage of plasma cells, diffuse pattern of bone marro involvement, and increase in the degree of fibrosis as correlated increase in M D (p 0.001, p 0.001, p 0.036 respectively). The present study suggested that evaluation of plasma cell infiltration pattern, fibrosis and micro-vessel density in bone marro biopsies of ne ly diagnosed plasma cell myeloma cases be useful tools in the management and maintenance of the treatment. Elevation in ith an percentage, migh

Evaluation of disease spectrum diagnosed with bone marrow biopsy at a tertiary healthcare center in Turkey Hematological diseases spectrum diagnosed with bone marrow biopsy

Aim: Bone marrow examination (BME) is commonly implemented to diagnose hemato-oncological diseases. There are only a few reports on diseases diagnosed via the BME and diagnostic yield in patients who applied to the hematology department This study aimed to identify the primary indications and diagnoses of BME in patients who underwent bone marrow biopsy at Dokuz Eylul University in Turkey

Evaluation of using fresh frozen plasma for patients with cirrhosis at a tertiary healthcare center in Turkey: Strict transfusion policies are essential

Aim: Management of blood transfusions is a critical issue, especially in cirrhotic patients, because of the absence of national policies in many countries. Fresh frozen plasma (FFP) is a common blood component misused excessively in various clinical situations and cirrhosis patients without any scientific rationale. We evaluated the FFP transfusions in patients with cirrhosis at our tertiary care hospital

Computed tomography characteristics of multiple myeloma and other osteolytic metastatic bone lesions

Background Differentiation of multiple myeloma (MM) from osteolytic metastatic (OM) bone lesions may be critical in patients with lytic bone lesions but can be challenging for radiologists. Purpose To determine whether computed tomography (CT) can be used to distinguish between MM and other OM bone lesions. Material and Methods In this retrospective study, 320 lesions of 207 patients diagnosed with MM or OM, based on biopsy or clinical examination, were evaluated. Eight qualitative features were evaluated by two radiologists blinded to the diagnoses. The chi-square and Fisher exact tests, and logistic regression analysis, were used to evaluate the relationships between the CT findings and diagnoses. Results High-density areas were more common in OM than MM lesions (85.2% and 19%, P < 0.001), as were perilesional sclerosis (38.9% vs. 13.2%, P < 0.001), heterogeneity (on non-contrast CT images, 60% vs. 19.1%, P < 0.001; on contrast enhanced CT images, 80.6% vs. 28.2%, P < 0.001), and ill-defined margins (34.6% vs. 9.1%, P < 0.001). Similarly, OM lesions showed high-density areas more than MM in evaluation of skeletal system subgroups (vertebrae, 93.8% vs. 29.8%, P < 0.0001; thoracic cage bones, 69.6% vs. 19.2%, P < 0.001; pelvic bones and sacrum, 84.8% vs. 7.7%, P < 0.001; peripheral skeletal bones, 81.5% vs. 8.3%, P < 0.001). Logistic regression analysis revealed that the presence of a high-density area in the lesion increased the probability of a metastasis 25.88-fold (R-2 = 0.516, P < 0.001). Conclusion MM and OM lesions can be differentiated by CT; OM lesions exhibit high- density areas

Therapeutic plasma exchange in neurological diseases: Eleven years experience at a tertiary care center in Turkey

Therapeutic plasma exchange (TPE) is an apheresis procedure in which plasma is separated from the blood cellular components ex vivo, allocated, and replaced with another plasma or a plasma-replacing fluid. This study aimed to define the rate of complications and determine TPE distribution in various neurological diseases. Our study is a retrospective analysis of neurologic diseases requiring TPE between 2008 and 2019 that were selected using the medical records of neurology departments and apheresis units database. We performed 1459 TPE procedures on 207 patients between 2008 and 2019. TPE Procedure is most frequently applied in patients with Myasthenia-Gravis syndrome (34.7%). The complication ratio was 1.6% from a total of 1459 TPE procedures. The most commonly specified adverse event was allergic reactions 11 (5.3%), followed by hypotension 6 (2.9%). TPE was safe and tolerable, with manageable complications in experienced hands