2,746 research outputs found
A Brief History of Web Crawlers
Web crawlers visit internet applications, collect data, and learn about new
web pages from visited pages. Web crawlers have a long and interesting history.
Early web crawlers collected statistics about the web. In addition to
collecting statistics about the web and indexing the applications for search
engines, modern crawlers can be used to perform accessibility and vulnerability
checks on the application. Quick expansion of the web, and the complexity added
to web applications have made the process of crawling a very challenging one.
Throughout the history of web crawling many researchers and industrial groups
addressed different issues and challenges that web crawlers face. Different
solutions have been proposed to reduce the time and cost of crawling.
Performing an exhaustive crawl is a challenging question. Additionally
capturing the model of a modern web application and extracting data from it
automatically is another open question. What follows is a brief history of
different technique and algorithms used from the early days of crawling up to
the recent days. We introduce criteria to evaluate the relative performance of
web crawlers. Based on these criteria we plot the evolution of web crawlers and
compare their performanc
Study of the acoustic emission response to a core-shell rubber-toughened, high-temperature composite
Highly Designable Protein Structures and Inter Monomer Interactions
By exact computer enumeration and combinatorial methods, we have calculated
the designability of proteins in a simple lattice H-P model for the protein
folding problem.
We show that if the strength of the non-additive part of the interaction
potential becomes larger than a critical value, the degree of designability of
structures will depend on the parameters of potential. We also show that the
existence of a unique ground state is highly sensitive to mutation in certain
sites.Comment: 14 pages, Latex file, 3 latex and 6 eps figures are include
PPE Antigen Rv2430c of Mycobacterium tuberculosis induces a strong B-cell response
The variation in sequence and length in the C-terminal region among members of the unique PE (Pro-Glu) and PPE (Pro-Pro-Glu) protein families of Mycobacterium tuberculosis is a likely source of antigenic variation, giving rise to the speculation that these protein families could be immunologically important. Based on in silico analysis, we selected a hypothetical open reading frame (ORF) encoding a protein belonging to the PPE family and having epitopes with predictably higher antigenic indexes. Reverse transcriptase PCR using total RNA extracted from in vitro-cultured M. tuberculosis H37Rv generated an mRNA product corresponding to this gene, indicating the expression of this ORF (Rv2430c) at the mRNA level. Recombinant protein expressed in Escherichia coli was used to screen the sera of M. tuberculosis-infected patients, as well as those of clinically healthy controls (n = 10), by enzyme-linked immunosorbent assay. The panel of patient sera comprised sera from fresh infection cases (category 1; n = 32), patients with relapsed tuberculosis (category 2; n = 30), and extrapulmonary cases (category 3; n = 30). Category 2 and 3 sera had strong antibody responses to the PPE antigen, equal to or higher than those to other well-known antigens, such as Hsp10 or purified protein derivative (PPD). However, a higher percentage of patients belonging to category 1, as opposed to clinically healthy controls, showed stronger antibody response against the PPE protein when probed with anti-immunoglobulin M (IgM) (71 versus 37.5%) or anti-IgG (62.5 versus 28.12%). Our results reveal that this PPE ORF induces a strong B-cell response compared to that generated by M. tuberculosis Hsp10 or PPD, pointing to the immunodominant nature of the protein
Electron Electric Dipole Moment from Lepton Flavor Violation
The general Minimal Supersymmetric Standard Model introduces new sources for
Lepton Flavor Violation (LFV) as well as CP-violation. In this paper, we show
that when both sources are present, the electric dipole moment of the electron,
, receives a contribution from the phase of the trilinear -term of
staus, . For , the value of ,
depending on the ratios of the LFV mass elements, can range between zero and
three orders of magnitude above the present bound. We show that the present
bound on rules out a large portion of the CP-violating and the LFV
parameter space which is consistent with the bounds on the LFV rare decays.
We show that studying the correlation between and the P-odd asymmetry
in helps us to derive a more conclusive bound on
We also discuss the possibility of cancelation among the contributions of
different CP-violating phases to .Comment: 35 pages, 9 figure
AmpliBASE MT: a Mycobacterium tuberculosis diversity knowledgebase
AmpliBASE MT is an online databank of high-resolution DNA fingerprints representing fluorescent amplified fragment length polymorphism (FAFLP) profiles or amplitypes developed for the Mycobacterium tuberculosis complex strains from 48 different countries. AmpliBASE MT is based on a relational database management system that is hyperlinked to visualize genotyping results in the form of DNA fingerprint images for individual strains. A flexible search system based on systematic comparisons of fragment sizes in base pairs allows inter-laboratory comparison of FAFLP profiles. Besides this, the database also displays previously published data on IS6110 profiles, spoligotypes, MIRU-VNTRs and large sequence polymorphisms along with the FAFLP records that will give the overall comparisons. Being the first of its kind, AmpliBASE MT is expected to be a very helpful tool in strengthening the concept of 'geographic genomics' and will be very helpful to molecular epidemiologists and those interested in diagnostic development for tuberculosis
Top pair Asymmetries at Hadron colliders with general couplings
Recently it has been shown that measurement of charge asymmetry of top pair
production at LHC excludes any flavor violating vector gauge boson that
could explain Tevatron forward-backward asymmetry (FBA). We consider the
general form of a gauge boson including left-handed, right-handed vector
and tensor couplings to examine FBA and charge asymmetry. To evaluate top pair
asymmetries at Tevatron and LHC, we consider mixing constraints on
flavor changing couplings and show that this model still explain
forward-backward asymmetry at Tevatron and charge asymmetry can not exclude it
in part of parameters space.Comment: 18 pages, 7 figure
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