第711回 千葉医学会例会・第20回 佐藤外科例会 32.

<p>It obtained by maximum likelihood method using HKY+<i>Г</i>+I as nucleotides' substitution model. Triangleshows the position of cluster C which is detailed in (A). See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0162492#pone.0162492.g001" target="_blank">Fig 1</a> legend for more details.</p

Estimated dates of HCV subtypes origin, as obtained under model combinations A to F.

<p>(A) Subtype 1a, cluster A. (B) subtype 1b, cluster B. (C) subtype 3a, cluster D. (D) subtype 3a, cluster E (see text for further details). The bars show the 95% credible intervals of each estimate.</p

Estimated evolutionary of each subtype (median and 95% confidence intervals).

<p>Estimated evolutionary of each subtype (median and 95% confidence intervals).</p

The mean value of exponential growth rates of HCV subtypes for which BSPs were calculated.

<p>(A) Subtype 1a, cluster A. (B) Subtype 1a, cluster B. (C) Subtype 1b, cluster C. (D) Subtype 3a, cluster D. (E) Subtype 3a, cluster E. The natural logarithm of the effective number of infections is plotted versus time period for which the corresponding BSP has a growing trend. The fitted regression equation to the natural logarithm of effective number of infections (as a dependent variable) and time (as an independent variable) is shown.</p

Bayesian Skyline Plots (BSPs) for strains of HCV subtypes.

<p>(A) Strains of subtype 1a, cluster A. (B) BSPs for subtype 1a, cluster B. (C) BSPs for subtype 1b, cluster C. (D) BSPs for subtype 3a, cluster D. (E) BSPs for subtype 3a, cluster E. The black lines are the estimates of the effective number of infections and the blue shaded areas indicate 95% credible intervals of effective number of infections. Black and grey dotted lines represent median estimation and lower bond of the 95% credible interval for the cluster age, respectively.</p