1 research outputs found
Mitochondria-Targeting Peptoids
Mitochondria-specific
delivery methods offer a valuable tool for
studying mitochondria-related diseases and provide breakthroughs in
therapeutic development. Although several small-molecule and peptide-based
transporters have been developed, peptoids, proteolysis-resistant
peptidomimetics, are a promising alternative to current approaches.
We designed a series of amphipathic peptoids and evaluated their cellular
uptake and mitochondrial localization. Two peptoids with cyclohexyl
residues demonstrated highly efficient cell penetration and mitochondrial
localization without significant adverse effects on the cells and
mitochondria. These mitochondria-targeting peptoids could facilitate
the selective and robust targeted delivery of bioactive compounds,
such as drugs, antioxidants, and photosensitizers, with minimal off-target
effects