Magnetic Nanoparticles for Ultrafast Mechanical Control of Inner Ear Hair Cells

We introduce cubic magnetic nanoparticles as an effective tool for precise and ultrafast control of mechanosensitive cells. The temporal resolution of our system is ∼1000 times faster than previously used magnetic switches and is comparable to the current state-of-the-art optogenetic tools. The use of a magnetism-gated switch reported here can address the key challenges of studying mechanotransduction in biological systems. The cube-shaped magnetic nanoparticles are designed to bind to components of cellular membranes and can be controlled with an electromagnet to exert pico-Newtons of mechanical force on the cells. The cubic nanoparticles can thus be used for noncontact mechanical control of the position of the stereocilia of an inner ear hair cell, yielding displacements of tens of nanometers, with sub-millisecond temporal resolution. We also prove that such mechanical stimulus leads to the influx of ions into the hair cell. Our study demonstrates that a magnetic switch can yield ultrafast temporal resolution, and has capabilities for remote manipulation and biological specificity, and that such magnetic system can be used for the study of mechanotransduction processes of a wide range of sensory systems

Quantitative Measurements of Size-Dependent Magnetoelectric Coupling in Fe₃O₄ Nanoparticles

Bulk magnetite (Fe₃O₄), the loadstone used in magnetic compasses, has been known to exhibit magnetoelectric (ME) properties below ∼10 K; however, corresponding ME effects in Fe₃O₄ nanoparticles have been enigmatic. We investigate quantitatively the ME coupling of spherical Fe₃O₄ nanoparticles with uniform diameters (<i>d</i>) from 3 to 15 nm embedded in an insulating host, using a sensitive ME susceptometer. The intrinsic ME susceptibility (MES) of the Fe₃O₄ nanoparticles is measured, exhibiting a maximum value of ∼0.6 ps/m at 5 K for <i>d</i> = 15 nm. We found that the MES is reduced with reduced <i>d</i> but remains finite until <i>d</i> = ∼5 nm, which is close to the critical thickness for observing the Verwey transition. Moreover, with reduced diameter the critical temperature below which the MES becomes conspicuous increased systematically from 9.8 K in the bulk to 19.7 K in the nanoparticles with <i>d</i> = 7 nm, reflecting the core–shell effect on the ME properties. These results point to a new pathway for investigating ME effect in various nanomaterials