Spin-wave propagation in the presence of inhomogeneous Dzyaloshinskii-Moriya interactions

We theoretically investigate spin-wave propagation through a magnetic metamaterial with spatially modulated Dzyaloshinskii-Moriya interaction. We establish an effective Schrodinger equation for spin waves and derive boundary conditions for spin waves passing through the boundary between two regions having different Dzyaloshinskii-Moriya interactions. Based on these boundary conditions, we find that the spin wave can be amplified at the boundary and the spin-wave band gap is tunable either by an external magnetic field or the strength of Dzyaloshinskii-Moriya interaction, which offers a spin-wave analog of the field-effect transistor in traditional electronics.112sciescopu

Minimization of Temperature Ranges between the Top and Bottom of an Air Flow Controlling Device through Hybrid Control in a Plant Factory

To maintain the production timing, productivity, and product quality of plant factories, it is necessary to keep the growth environment uniform. A vertical multistage type of plant factory involves different levels of growing trays, which results in the problem of difference in temperature among vertically different locations. To address it, it is necessary to install air flow devices such as air flow fan and cooling/heating device at the proper locations in order to facilitate air circulation in the facility as well as develop a controlling technology for efficient operation. Accordingly, this study compares the temperature and air distribution within the space of a vertical multistage closed-type plant factory by controlling cooling/heating devices and air flow fans harmoniously by means of the specially designed testbed. The experiment results indicate that in the hybrid control of cooling and heating devices and air flow fans, the difference in temperature decreased by as much as 78.9% compared to that when only cooling and heating devices were operated; the air distribution was improved by as much as 63.4%

Substitution of Heavy Complementarity Determining Region 3 (CDR-H3) Residues Can Synergistically Enhance Functional Activity of Antibody and Its Binding Affinity to HER2 Antigen

To generate a biobetter that has improved therapeutic activity, we constructed scFv libraries via random mutagenesis of several residues of CDR-H3 and -L3 of hu4D5. The scFv clones were isolated from the phage display libraries by stringent panning, and their anti-proliferative activity against HER2-positive cancer cells was evaluated as a primary selection criterion. Consequently, we selected AH06 as a biobetter antibody that had a 7.2-fold increase in anti-proliferative activity (IC50: 0.81 nM) against the gastric cancer cell line NCI-N87 and a 7.4-fold increase in binding affinity (K-D : 60 pM) to HER2 compared to hu4D5. The binding energy calculation and molecular modeling suggest that the substitution of residues of CDR-H3 to W98, F100c, A101 and L102 could stabilize binding of the antibody to HER2 and there could be direct hydrophobic interactions between the aromatic ring of W98 and the aliphatic group of I613 within HER2 domain IV as well as the heavy and light chain hydrophobic interactions by residues F100c, A101 and L102 of CDR-H3. Therefore, we speculate that two such interactions were exerted by the residues W98 and F100c. A101 and L102 may have a synergistic effect on the increase in the binding affinity to HER2. AH06 specifically binds to domain IV of HER2, and it decreased the phosphorylation level of HER2 and AKT. Above all, it highly increased the overall level of p27 compared to hu4D5 in the gastric cancer cell line NCI-N82, suggesting that AH06 could potentially be a more efficient therapeutic agent than hu4D5.OAIID:RECH_ACHV_DSTSH_NO:T201620640RECH_ACHV_FG:RR00200001ADJUST_YN:EMP_ID:A002901CITE_RATE:2.67DEPT_NM:화학생물공학부EMAIL:[email protected]_YN:YCONFIRM: