Design of Cognitive Rehabilitation Training System using Artificial Intelligence

This study is a study to design a cognitive(dementia) rehabilitation training system using the MMSE-DS protocol and the GDS protocol using artificial intelligence to analyze the user's cognitive ability and infer cognitive domain content correlation inference algorithms. For research on cognitive judgment technology using artificial intelligence, We provide an integrated cognitive rehabilitation service platform, provide customized training content by building a cognitive rehabilitation evaluation and training user data storage and analysis database, and design an algorithm to help improve users' learning ability by building an artificial intelligence system. The user's cognitive ability analysis and cognitive domain content inference algorithm using artificial intelligence is the purpose is to design a cognitive judgment platform and implement a system to apply cognitive evaluation to people with mild cognitive impairment and utilize cognitive rehabilitation content based on cognitive judgment technology system design technology. Through this study, we aim to provide direction for the future field of cognitive rehabilitation combined with artificial intelligenc

Antiasthmatic Effects of Hesperidin, a Potential Th2 Cytokine Antagonist, in a Mouse Model of Allergic Asthma

Background and Objective. The features of asthma are airway inflammation, reversible airflow obstruction, and an increased sensitivity to bronchoconstricting agents, termed airway hyperresponsiveness (AHR), excess production of Th2 cytokines, and eosinophil accumulation in the lungs. To investigate the antiasthmatic potential of hesperidin as well as the underlying mechanism involved, we studied the inhibitory effect and anti-inflammatory effect of hesperidin (HPN) on the production of Th2 cytokines, eotaxin, IL-17, -OVA-specific IgE in vivo asthma model mice. Methods. In this paper, BALB/c mice were systemically sensitized to ovalbumin (OVA) followed intratracheally, intraperitoneally, and by aerosol allergen challenges. We investigated the effect of HPN on airway hyperresponsiveness, pulmonary eosinophilic infiltration, various immune cell phenotypes, Th2 cytokine production and OVA-specific IgE production in a mouse model of asthma. Results. In BALB/c mice, we found that HPN-treated groups had suppressed eosinophil infiltration, allergic airway inflammation, and AHR, and these occurred by suppressing the production of IL-5, IL-17, and OVA-specific IgE. Conclusions. Our data suggest that the therapeutic mechanism by which HPN effectively treats asthma is based on reductions of Th2 cytokines (IL-5), eotaxin, OVA-specific IgE production, and eosinophil infiltration via inhibition of GATA-3 transcription factor

Effects of Corni fructus on ovalbumin-induced airway inflammation and airway hyper-responsiveness in a mouse model of allergic asthma

<p>Abstract</p> <p>Background</p> <p>Allergic asthma is a chronic inflammatory lung disease that is characterized by airway hyperresponsiveness (AHR) to allergens, airway oedema, increased mucus secretion, excess production of T helper-2 (Th2) cytokines, and eosinophil accumulation in the lungs. Corni fructus (CF) is a fruit of <it>Cornus officinalis </it>Sieb. Et. Zucc. (Cornaceae) and has been used in traditional Korean medicine as an anti-inflammatory, analgesic, and diuretic agent. To investigate the anti-asthmatic effects of CF and their underlying mechanism, we examined the influence of CF on the development of pulmonary eosinophilic inflammation and airway hyperresponsiveness in a mouse model of allergic asthma.</p> <p>Methods</p> <p>In this study, BALB/c mice were systemically sensitized to ovalbumin (OVA) by intraperitoneal (i.p.), intratracheal (i.t.) injections and intranasal (i.n.) inhalation of OVA. We investigated the effect of CF on airway hyperresponsiveness, pulmonary eosinophilic infiltration, various immune cell phenotypes, Th2 cytokine production, and OVA-specific immunoglobulin E (IgE) production.</p> <p>Results</p> <p>The CF-treated groups showed suppressed eosinophil infiltration, allergic airway inflammation, and AHR via reduced production of interleuin (IL) -5, IL-13, and OVA-specific IgE.</p> <p>Conclusions</p> <p>Our data suggest that the therapeutic effects of CF in asthma are mediated by reduced production of Th2 cytokines (IL-5), eotaxin, and OVA-specific IgE and reduced eosinophil infiltration.</p

Hazard analysis of typhoon-related external events using extreme value theory

AbstractBackgroundAfter the Fukushima accident, the importance of hazard analysis for extreme external events was raised.MethodsTo analyze typhoon-induced hazards, which are one of the significant disasters of East Asian countries, a statistical analysis using the extreme value theory, which is a method for estimating the annual exceedance frequency of a rare event, was conducted for an estimation of the occurrence intervals or hazard levels. For the four meteorological variables, maximum wind speed, instantaneous wind speed, hourly precipitation, and daily precipitation, the parameters of the predictive extreme value theory models were estimated.ResultsThe 100-year return levels for each variable were predicted using the developed models and compared with previously reported values. It was also found that there exist significant long-term climate changes of wind speed and precipitation.ConclusionA fragility analysis should be conducted to ensure the safety levels of a nuclear power plant for high levels of wind speed and precipitation, which exceed the results of a previous analysis

Creating Value with Acquisition Based Dynamic Capabilities (ABDC): A Study of Mergers and Acquisitions in the Regulated Energy Industry

M&A research has consistently shown that value is destroyed for a majority of acquirers. Despite initial small positive gains at deal announcement, within a year of closing the transaction a majority of acquirers experience overall negative returns. Nevertheless, the constant pressures to grow leave company leaders few other viable options than pursuing M&A. This ever present cycle of value destruction is of interest to both scholars and practitioners. Of interest is what can be done differently by the acquirer to prevent the inevitable value erosion from occurring. To investigate this question, the author develops an adapted version of the Acquisition Based Dynamic Capabilities (ABDC) framework, a theoretical extension of Dynamic Capability theory. The framework is helpful in identifying what corporate M&A capabilities contribute to value creation through a transaction lifecycle. The adapted ABDC framework provides a means to quantify the differing impacts to value creation among the M&A capabilities of “Selecting and Identifying”, “Transacting and Executing” and “Reconfiguring and Integrating”. The empirical study utilizes 337 regulated energy, public company transactions, closed between 1995 and 2014. This industry is appropriate to study the application of this theory as it benefits from long dated deal timelines and specific milestone events (deal announcement, regulatory approval, financial closing, etc.) providing clear points of delineation for measurement purposes. Performance is measured using weak and semi-strong specifications of shareholder returns with a “golden set” of measures identified. Additionally, the impacts on the ABDC measures from shock waves, bandwagon effects, management traits, financial factors, deal complexity and other relevant factors are all evaluated to test for their impacts on the analyzed transactions. The results suggest that despite many acquirers receiving some positive value accretion from announcement and short-term post-closing returns, larger one year post-close reductions in value eclipse previous gains for most acquirers. The results validate the importance of the Reconfiguring and Integrating (R&I) phase of an acquisition. Comparisons to Top and Poor Performers provide a clear set of recommendations for future energy industry acquirers

The Increase of Educational Opportunity in Korea under the Japanese Occupation: For Whom the Bell Told?

1998On October 11th, 1995, the minister of governmental administration, Japan, Dakami Eto tried to justify the Japanese occupation of Korea by saying, "Japan did do some good things for Korea during the Japanese occupation, like building about 5000 schools". This is just one of the string of insistences that have been made frequently by the extreme-right Japanese politicians in Japan after the Independence of Korea in 1945 and is an example of the insistence that Japan's occupation had contributed to the modernization of Korea. And what makes his assertion distinct is the only fact that he used to support it was a specific reference to education, more specifically, the increase of educational opportunity