Non-HLA RA susceptibility SNP allele frequencies and their association with seropositive RA in WTCCC and UKRAGG.

<p>SNPs are ordered by significance (most significant by <i>P</i>_GWAS listed first); all alleles attained genome-wide significance in the published meta-analysis; Ca = Cases; Co = Controls; MAF = Minor Allele Frequency;</p>a<p> = MAF in controls.</p

Risk categorisation of RA and controls by each prediction model.

<p>The y-axis on each graph refers to the proportion of cases/controls in each risk category; cont = controls; sero+ = seropositive RA; ACPA+ = ACPA-positive RA.</p

Number of individuals evaluated in each prediction model.

<p>Number of individuals evaluated in each prediction model.</p

Prediction model generated risk profiles for ACPA-positive RA and controls.

<p>Panel A = WTCCC; Panel B = UKRAGG; the upper set of lines for each model refer to RA cases; the lower set of lines refer to controls; OR = odds ratio.</p

Kaplan-Meier curves: RA age of onset stratified by HLA model risk categorisation and smoking status.

<p>Panel A = WTCCC Curves Stratified By Risk Categorisation; Panel B = UKRAGG Curves Stratified By Risk Categorisation; Panel C = WTCCC Curves Stratified By Risk Categorisation and Ever-Smoking Status; Panel D = UKRAGG Curves Stratified By Risk Categorisation and Ever-Smoking Status; Δ = change in onset age; Δ_m = maximum change in onset age across strata.</p

Clinical characteristics of WTCCC/UKRAGG cases and controls included in modelling.

<p>Data are number (%) unless otherwise stated. The following data are missing from WTCCC: gender in 2 cases and 169 controls; RF status in 5 cases; ACPA status in 290 cases; age of onset missing/inaccurate in 63 cases; erosive status in 96 cases; smoking status in 76 male cases, 204 female cases and 3 female controls. The following data are missing from UKRAGG: gender in 14 controls; RF status in 60 cases; ACPA status in 844 cases; age of onset missing/inaccurate in 93 cases; erosive status in 1,432 cases; nodular status in 378 cases; smoking status in 226 male cases, 513 female cases, 274 male controls and 284 female controls.</p>a<p> = % of males that are ever smokers;</p>b<p> = % of females that are ever smokers.</p