Selenized Chickpea Sprouts Hydrolysates as a Potential Anti-Aging Ingredient

Skin aging represents a health and aesthetic problem that could result in infections and skin diseases. Bioactive peptides can potentially be used in skin aging regulation. Chickpea (Cicer arietinum L.) selenoproteins were obtained from germination with 2 mg Na2SeO3/100 g of seeds for 2 days. Alcalase, pepsin, and trypsin were used as hydrolyzers, and a membrane −1) observed in the selenized hydrolysates suggested the insertion of Se into the protein. Hydrolysates from pepsin and trypsin had the highest antioxidant potential. Se enhanced the stability of total protein and protein hydrolysates through time and increased their antioxidant capacity. Hydrolysates > 10 kDa had higher elastase and collagenase inhibition than the total protein and hydrolysates < 10 kDa. Protein hydrolysates < 10 kDa 6 h before UVA radiation had the highest inhibition of collagen degradation. Selenized protein hydrolysates showed promising antioxidant effects that could be related to skin anti-aging effects

Addressing key features involved in bioactive extractability of vigor prickly pears submitted to high hydrostatic pressurization

Prickly pears are relevant sources of bioactive compounds with potential biological activities. However, to become bioaccessible, these compounds must be released from the food matrix. High hydrostatic pressure (HHP) may contribute to bioaccessibility by promoting the liberation of bioactive constituents from their intracellular compartments. Our aim was to address key features involved in the high hydrostatic pressurization (18–34°C) of prickly pear fruits to promote bioactive extractability. We studied the effects of the come‐up time (CUT) and holding time (HT; 5 min) at low (60, 100, and 150 MPa) and high pressures (400, 500, and 600 MPa) in whole‐pressurized and sliced‐pressurized fruits. The best overall treatment was found by submitting whole prickly pears to 500 MPa during the CUT. In this treatment, 104.0, 150.8, and 100.5% retention of betalains, phenolics, and ascorbic acid were observed in peels; and 130.7, 121.4, and 128.4% retention were observed in pulps.This work was supported by FunFoodEmertec (Tecnologico de Monterrey, Mexico) and project RTA2015‐00044‐C02‐02 (Spanish Ministry of Economy and Competitiveness). Author Andrea Gómez‐Maqueo thanks CONACyT, Mexico, for her doctoral scholarship (692751).Peer reviewe

Metabolism and anticancer mechanisms of selocompounds: Comprehensive review

Selenium (Se) is an essential micronutrient with several functions in cellular and molecular anticancer processes. There is evidence that Se depending on its chemical form and the dosage use could act as a modulator in some anticancer mechanisms. However, the metabolism of organic and inorganic forms of dietary selenium converges on the main pathways. Different selenocompounds have been reported to have crucial roles as chemopreventive agents, such as antioxidant activity, activation of apoptotic pathways, selective cytotoxicity, antiangiogenic effect, and cell cycle modulation. Nowadays, great interest has arisen to find therapies that could enhance the antitumor effects of different Se sources. Herein, different studies are reported related to the effects of combinatorial therapies, where Se is used in combination with proteins, polysaccharides, chemotherapeutic agents or as nanoparticles. Another important factor is the presence of single nucleotide polymorphisms in genes related to Se metabolism or selenoprotein synthesis which could prevent cancer. These studies and mechanisms show promising results in cancer therapies. This review aims to compile studies that have demonstrated the anticancer effects of Se at molecular levels and its potential to be used as chemopreventive and in cancer treatment.This research was supported by the Nutriomics y Tecnologías Emergentes Research Chair Funds from Tecnológico de Monterrey, the Consejo Superior de Investigaciones Científicas through the i-Link Program (LINKB20023), and by the Spanish Ministry of Science and Innovation through the PID2019-106071RB-I00 project. The scholarships of Juan Pablo Dávila Vega (CVU-1006860), Ana Carolina Gastélum Hernández (CVU-703109), and Sayra Nayely Serrano Sandoval (CVU-737636) were provided by Consejo Nacional de Ciencia y Tecnología (CONACyT).Peer reviewe