Preferencia entre alumnos universitarios de México y Corea del Sur con respecto al perfil y el tercio inferior de la cara

ResumenObjetivoEvaluar la preferencia respecto al perfil facial entre una comunidad de jóvenes estudiantes en Corea del Sur y México durante el 2012.Material y métodos400 encuestas se aplicaron en cuatro facultades de la Universidad Nacional Autónoma de México y en cuatro facultades de la Universidad Nacional de Seúl de Corea del Sur; 50 personas por cada facultad (25 hombres y 25 mujeres). El formato se realizó mediante la obtención de un ideal, y a través de un software se modificó en sentido vertical y sagital para obtener diferentes perfiles y tercios, se realizaron en español y en coreano.ResultadosNo hubo diferencias estadísticas significativas en cuanto al sexo y nacionalidad. El perfil masculino favorito fue el cóncavo y en el femenino fue el convexo, ambos con diferencias estadísticas significativas por profesiones (χ2=19.505 p=.003) (χ2=32.742 p<0.001).ConclusionesEl perfil facial preferido fue el cóncavo en hombres y el convexo en mujeres. El perfil facial que menos gustó es el convexo en hombres y el cóncavo en mujeres. El tercio inferior preferido fue el proporcionado y el que menos agradó fue el tercio inferior disminuido. No hubo diferencias entre nacionalidades ni sexo, pero si por profesiones.AbstractObjectiveTo assess the preference regarding facial profile among a community of young students in South Korea and Mexico in 2012.Material and Methods400 surveys were conducted in 4 faculties of UNAM of Mexico and 4 faculties of the SNU in South Korea, 50 for each faculty (25 men and 25 women). The format was done by obtaining an ideal and through a software sagittal and vertical modifications for different profiles and thirds, were conducted in Spanish and Korean.ResultsThere were no statistically significant differences in gender and nationality. The favorite male profile was concave and the favorite female profile was convex, both with significant statistical difference by occupation (χ2=19.505 p=.003) (χ2=32.742 p<0.001).ConclusionsThe preferred facial profile was concave in men and convex in women. The worst facial profile was convex in men and concave in women. The favorite lower facial third was proportionate and the least liked was a diminished lower third. There were no differences between nationalities or gender, but by professions

Percepción de la estética de la sonrisa por odontólogos especialistas y pacientes

"El objetivo del presente estudio fue conocer la percepción de los parámetros estéticos de la sonrisa, por odontólogos especialistas y pacientes que acuden al Departamento de Ortodoncia de la DEPeI, UNAM. Método: Se realizó un estudio observacional descriptivo en el que se observaron tres series de cinco fotografías de sonrisas por 284 participantes hombres y mujeres, de los cuales 144 eran odontólogos especialistas y 140 pacientes. Ambos grupos calificaron fotografías de sonrisas que fueron modificadas con el programa PhotoShop®"

Preclinical Studies and Drug Combination of Low-Cost Molecules for Chagas Disease

Chagas disease is caused by the protozoan Trypanosoma cruzi (T. cruzi). It remains the major parasitic disease in Latin America and is spreading worldwide, affecting over 10 million people. Hundreds of new compounds with trypanosomicidal action have been identified from different sources such as synthetic or natural molecules, but they have been deficient in several stages of drug development (toxicology, scaling-up, and pharmacokinetics). Previously, we described a series of compounds with simple structures, low cost, and environmentally friendly production with potent trypanosomicidal activity in vitro and in vivo. These molecules are from three different families: thiazolidenehydrazines, diarylideneketones, and steroids. From this collection, we explored their capacity to inhibit the triosephosphate isomerase and cruzipain of T. cruzi. Then, the mechanism of action was explored using NMR metabolomics and computational molecular dynamics. Moreover, the mechanism of death was studied by flow cytometry. Consequently, five compounds, 314, 793, 1018, 1019, and 1260, were pre-clinically studied and their pharmacologic profiles indicated low unspecific toxicity. Interestingly, synergetic effects of diarylideneketones 793 plus 1018 and 793 plus 1019 were evidenced in vitro and in vivo. In vivo, the combination of compounds 793 plus 1018 induced a reduction of more than 90% of the peak of parasitemia in the acute murine model of Chagas disease