Catalytic C–H Allylation and Benzylation of Pyrazoles

We describe a general approach for the synthesis of allylated and benzylated pyrazoles. An electron-withdrawing substituent, such as nitro, chloro, and ester groups, at C4 renders the Lewis basic nitrogen atom to be less basic and the C–H bond more acidic than the ones of the parent ring, enabling Pd-catalyzed C–H allylation and benzylation reactions of pyrazoles. The new method expanding the scope of the C–H functionalization of pyrazoles beyond arylation reactions provides a rapid access to complex pyrazole compounds

Groebke–Blackburn–Bienaymé Reaction for DNA-Encoded Library Technology

This study presents a DNA-compatible synthesis of diverse 5-arylimidazo[1,2-a]pyridin-3-amine derivatives using the Suzuki–Miyaura reaction, followed by a Groebke–Blackburn–Bienaymé (GBB) reaction. The GBB reaction demonstrates a wide substrate scope, mild one-pot reaction conditions, and compatibility with subsequent enzymatic ligation, highlighting its potential in DNA-encoded library technology