Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis

The interesting observation was made 20 years ago that psychotic manifestations in patients with systemic lupus erythematosus are associated with the production of antiribosomal-P protein (anti-P) autoantibodies. Since then, the pathogenic role of anti-P antibodies has attracted considerable attention, giving rise to long-term controversies as evidence has either contradicted or confirmed their clinical association with lupus psychosis. Furthermore, a plausible mechanism supporting an anti-P–mediated neuronal dysfunction is still lacking. We show that anti-P antibodies recognize a new integral membrane protein of the neuronal cell surface. In the brain, this neuronal surface P antigen (NSPA) is preferentially distributed in areas involved in memory, cognition, and emotion. When added to brain cellular cultures, anti-P antibodies caused a rapid and sustained increase in calcium influx in neurons, resulting in apoptotic cell death. In contrast, astrocytes, which do not express NSPA, were not affected. Injection of anti-P antibodies into the brain of living rats also triggered neuronal death by apoptosis. These results demonstrate a neuropathogenic potential of anti-P antibodies and contribute a mechanistic basis for psychiatric lupus. They also provide a molecular target for future exploration of this and other psychiatric diseases

Efecto de los antimaláricos sobre los diferentes dominios del índice de daño SLICC en pacientes de la cohorte GLADEL

Objetivos: estimar el efecto de los antimaláricos (AM) sobre los diferentes dominios del índice de daño SLICC (SDI). Métodos: se estudiaron pacientes con diagnóstico clínico reciente (≤2 años) de lupus eritematoso sistémico (LES) de la cohorte GLADEL

Influence of Solar Radiation in Cutaneous Manifestations of Lupus: Data from the Gladel Cohort

Hosp Italiano Buenos Aires, Rheumatol Sect, Buenos Aires, DF, ArgentinaGLADEL, Rosario, Santa Fe, ArgentinaHosp Privado Cordoba, Serv Reumatol, Cordoba, ArgentinaUniv Fed Goias, Fac Med, Goiania, Go, BrazilUniv Sao Paulo, Fac Med, Hosp Clin, Rheumatol, Sao Paulo, BrazilUniv Fed Sao Paulo, Rheumatol Div, Dept Med, Escola Paulista Med, Sao Paulo, BrazilUniv Bosque, Fac Med, Bogota, ColombiaCtr Invest Med Quirurg, Havana, CubaPontificia Univ Catolica Chile, Med Rheumatol, Santiago, ChileHosp Gen Occidente Seguro Social, Guadalajara, Jalisco, MexicoHosp Especialidades 25, Serv Reumatol, Inst Mexicano Seguro Social, Monterrey, MexicoHosp Nacl Guillermo Almenara Irigoyen, Lima, PeruHosp Cent San Cristobal, Unidad Reumatol, San Cristobal, VenezuelaUniv Alabama Birmingham, Dept Med, Div Clin Immunol & Rheumatol, Birmingham, AL USASanatorio Parque, Rosario, Santa Fe, ArgentinaRheumatology Div/Dept of Med, Escola Paulista de Medicina (EPM) - Universidade Federal de São Paulo (UNIFESP), Sao Paulo, BrazilWeb of Scienc

Effect of Antimalarials over the Different Domains of the Damage INDEX in Latin American SLE Patients

GLADEL, Rosario, Santa Fe, ArgentinaGLADEL Consultant, Rosario, Santa Fe, ArgentinaUniv Alabama Birmingham, Birmingham, AL USAGLADEL, Lima, PeruHosp Italiano Buenos Aires, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Internal Med Serv, CABA, Rheumatol Unit, Buenos Aires, DF, ArgentinaGLADEL, Medellin, ColombiaGLADEL, Mexico City, DF, MexicoInst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, MexicoHosp Gen Occidente Seguro Social, Guadalajara, Jalisco, MexicoInst Nacl Cardiol Ignacio Chavez, Rheumatol, Mexico City, DF, MexicoCtr Med ABC, Mexico City, DF, MexicoHosp Especialidades 25, Inst Mexicano Seguro Social, Serv Reumatol, Monterrey, MexicoCtr Invest Med Quirurg, Havana, CubaGLADEL, Havana, CubaUniv Antioquia, Fac Med, Grp Inmunol Celular & Inmunogenet, Medellin, ColombiaMedicarte IPS, Medellin, ColombiaHosp Univ Caracas, Ctr Nacl Enfermedades Reumat, Serv Reumatol, Caracas, VenezuelaGLADEL, Caracas, VenezuelaHosp Nacl Guillermo Almenara Irigoyen, Lima, PeruHosp Guillermo Almenara Irigoyen, EsSalud, Rheumatol, Lima, PeruGLADEL, Santiago, ChileUniv Chile, Fac Med, Hosp Salvador, Rheumatol Unit, Santiago, ChileUniv Fed Sao Paulo, Rheumatol Div, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Rheumatol Div, Sao Paulo, BrazilGLADEL, Sao Paulo, BrazilGLADEL, Porto Alegre, RS, BrazilGLADEL, Pernambuco, BrazilGLADEL, Goias, BrazilUniv Sao Paulo, Fac Med, Rheumatol, Sao Paulo, BrazilHosp Italiano Buenos Aires, Internal Med Serv, Rheumatol Unit, Buenos Aires, DF, ArgentinaUniv Cordoba, Hosp Privado, Rheumatol, Rheumatol Unit, Cordoba, ArgentinaCentro Med Codoba, Rheumatol, Cordoba, ArgentinaInst Invest Med Alfredo Lanari, Rheumatol Unit, Buenos Aires, DF, ArgentinaHIGA Gen San Martin Plata, Rheumatol, La Plata, ArgentinaGLADEL, Cordoba, ArgentinaEmory Univ, Sch Med, Div Rheumatol, Atlanta, GA USASanatorio Britanico, Rosario, Santa Fe, ArgentinaGLADEL, Mar Del Plata, ArgentinaGLADEL, Medellin, ColombiaUniv Fed Sao Paulo, Rheumatol Div, Sao Paulo, BrazilWeb of Scienc