4 research outputs found
Two Anhydrous and a Trihydrate Form of Tilorone Dihydrochloride: Hydrogen-Bonding Patterns and Reversible Hydration/Dehydration Solid-State Transformation
During the polymorph screening of an active pharmaceutical
ingredient
tilorone dihydrochloride (chemical name 2,7-bisÂ[2-(diethylamino)Âethoxy]-9-fluorenone
dihydrochloride) two new polymorphic modifications î—¸ <b>III</b> and <b>IV</b> î—¸ were obtained. The crystal
structures of both polymorphs were established from X-ray powder diffraction.
An interesting phenomenon has been observed at ambient conditions
for <b>III</b>, which transforms into a novel hydrated form <b>IIIh</b> during 2–3 h when the humidity in the storage
room increases to 70% or more. As soon as the relative humidity falls
to 30% or less, <b>IIIh</b> transforms into the parent anhydrous
form <b>III</b> within an hour. Form <b>IIIh</b> has been
identified as a trihydrate of tilorone dihydrochloride, and its crystal
structure has been established from X-ray powder diffraction. On the
basis of the crystal structures and hydrogen-bonding patterns, a mechanistic
model of reversible hydration/dehydration solid-state transformation <b>III</b> ↔ <b>IIIh</b> depending on the relative humidity
is proposed
Two Anhydrous and a Trihydrate Form of Tilorone Dihydrochloride: Hydrogen-Bonding Patterns and Reversible Hydration/Dehydration Solid-State Transformation
During the polymorph screening of an active pharmaceutical
ingredient
tilorone dihydrochloride (chemical name 2,7-bisÂ[2-(diethylamino)Âethoxy]-9-fluorenone
dihydrochloride) two new polymorphic modifications î—¸ <b>III</b> and <b>IV</b> î—¸ were obtained. The crystal
structures of both polymorphs were established from X-ray powder diffraction.
An interesting phenomenon has been observed at ambient conditions
for <b>III</b>, which transforms into a novel hydrated form <b>IIIh</b> during 2–3 h when the humidity in the storage
room increases to 70% or more. As soon as the relative humidity falls
to 30% or less, <b>IIIh</b> transforms into the parent anhydrous
form <b>III</b> within an hour. Form <b>IIIh</b> has been
identified as a trihydrate of tilorone dihydrochloride, and its crystal
structure has been established from X-ray powder diffraction. On the
basis of the crystal structures and hydrogen-bonding patterns, a mechanistic
model of reversible hydration/dehydration solid-state transformation <b>III</b> ↔ <b>IIIh</b> depending on the relative humidity
is proposed
Two Anhydrous and a Trihydrate Form of Tilorone Dihydrochloride: Hydrogen-Bonding Patterns and Reversible Hydration/Dehydration Solid-State Transformation
During the polymorph screening of an active pharmaceutical
ingredient
tilorone dihydrochloride (chemical name 2,7-bisÂ[2-(diethylamino)Âethoxy]-9-fluorenone
dihydrochloride) two new polymorphic modifications î—¸ <b>III</b> and <b>IV</b> î—¸ were obtained. The crystal
structures of both polymorphs were established from X-ray powder diffraction.
An interesting phenomenon has been observed at ambient conditions
for <b>III</b>, which transforms into a novel hydrated form <b>IIIh</b> during 2–3 h when the humidity in the storage
room increases to 70% or more. As soon as the relative humidity falls
to 30% or less, <b>IIIh</b> transforms into the parent anhydrous
form <b>III</b> within an hour. Form <b>IIIh</b> has been
identified as a trihydrate of tilorone dihydrochloride, and its crystal
structure has been established from X-ray powder diffraction. On the
basis of the crystal structures and hydrogen-bonding patterns, a mechanistic
model of reversible hydration/dehydration solid-state transformation <b>III</b> ↔ <b>IIIh</b> depending on the relative humidity
is proposed
Two Anhydrous and a Trihydrate Form of Tilorone Dihydrochloride: Hydrogen-Bonding Patterns and Reversible Hydration/Dehydration Solid-State Transformation
During the polymorph screening of an active pharmaceutical
ingredient
tilorone dihydrochloride (chemical name 2,7-bisÂ[2-(diethylamino)Âethoxy]-9-fluorenone
dihydrochloride) two new polymorphic modifications î—¸ <b>III</b> and <b>IV</b> î—¸ were obtained. The crystal
structures of both polymorphs were established from X-ray powder diffraction.
An interesting phenomenon has been observed at ambient conditions
for <b>III</b>, which transforms into a novel hydrated form <b>IIIh</b> during 2–3 h when the humidity in the storage
room increases to 70% or more. As soon as the relative humidity falls
to 30% or less, <b>IIIh</b> transforms into the parent anhydrous
form <b>III</b> within an hour. Form <b>IIIh</b> has been
identified as a trihydrate of tilorone dihydrochloride, and its crystal
structure has been established from X-ray powder diffraction. On the
basis of the crystal structures and hydrogen-bonding patterns, a mechanistic
model of reversible hydration/dehydration solid-state transformation <b>III</b> ↔ <b>IIIh</b> depending on the relative humidity
is proposed