4b,5,6,9-Tetrahydro-7<i>H</i>-dibenzo[<i>c</i>,<i>e</i>]pyrrolo[1,2-<i>a</i>]azepin-7-one

A simple approach to synthesize 4b,5,6,9-tetrahydro-7H-dibenzo[c,e]pyrrolo[1,2-a]azepin- 7-one has been developed, based on a three-step transformation of 2-(2-bromophenyl)cyclopropane-1,1-diester. The key stage in this method is an intramolecular cross-coupling of 1-(2-bromobenzyl)-5-(2-bromophenyl)pyrrolidin-2-one under continuous flow conditions in an H-Сube-Pro using commercially available supported Pd catalysts

Synthesis of Imidazo[2,1‑<i>b</i>]thiazoles via Copper-Catalyzed A³‑Coupling in Batch and Continuous Flow

A straightforward method for the synthesis of functionalized imidazo­[2,1-<i>b</i>]­thiazoles starting from benzaldehydes, 2-aminothiazoles, and alkynes under copper­(I,II) catalysis was developed. The protocol allows the construction of a variety of aryl-substituted imidazo­[2,1-<i>b</i>]­benzothiazoles, -[2,1-<i>b</i>]­thiazoles, and -[2,1-<i>b</i>]­[1,3,4]­thiadiazoles. The reactions were easy to perform affording most of the desired products in 33–93% yields. The intensification of the process in a continuous-flow reactor increases the products’ yields up to quantitative

Synthesis of Imidazo[2,1‑<i>b</i>]thiazoles via Copper-Catalyzed A³‑Coupling in Batch and Continuous Flow

A straightforward method for the synthesis of functionalized imidazo­[2,1-<i>b</i>]­thiazoles starting from benzaldehydes, 2-aminothiazoles, and alkynes under copper­(I,II) catalysis was developed. The protocol allows the construction of a variety of aryl-substituted imidazo­[2,1-<i>b</i>]­benzothiazoles, -[2,1-<i>b</i>]­thiazoles, and -[2,1-<i>b</i>]­[1,3,4]­thiadiazoles. The reactions were easy to perform affording most of the desired products in 33–93% yields. The intensification of the process in a continuous-flow reactor increases the products’ yields up to quantitative