“World Nationality” by Eyes of it’s Critics (Five Arguments against “Saturated” Cosmopolitism of M. Nussbaum)

The objective of this article is the review and critique of the analysis of global citizenship through the lens of political philosophy of communitarianism, neo-Marxist world-system analysis, liberal nationalism and traditionalism

ПРОЕКТ ФЕДЕРАЛЬНЫЕ ТЕРРИТОРИИ КАК ОБЪЕКТ ПРОСТРАНСТВЕННОГО РАЗВИТИЯ СИБИРИ И ДАЛЬНЕГО ВОСТОКА РОССИИ

The study is devoted to the spatial development of Siberia and the Far East of Russia. The role of federal districts as established macro-regions is considered - in optimizing territorial planning and correction of subjects of interregional management, and isolating project federal territories on their basis - as objects of sustainable-safe spatial development. The main focus is on the formation of a promising spatial (infrastructure) framework for the development of macroregions, including the identification of advanced growth nodes (the so-called “second” and “third” cities of macroregional subjects) and the links between them (transport axes and corridors) that are significant in the global economic context. The findings of the study can be used both in strategic planning at the level of federal districts and in further research at the national and interregional levels.El estudio está dedicado al desarrollo espacial de Siberia y el Lejano Oriente de Rusia. El papel de los distritos federales como macrorregiones establecidas se considera, en la optimización de la planificación territorial y la corrección de los temas de la gestión interregional, y el aislamiento de los territorios federales del proyecto, como objetos de desarrollo espacial sostenible y seguro. El enfoque principal es la formación de un marco espacial (infraestructura) prometedor para el desarrollo de macrorregiones, incluida la identificación de nodos de crecimiento avanzados (las llamadas "segunda" y "tercera" ciudades de sujetos macrorregionales) y los vínculos entre ellas (ejes y corredores de transporte) que son significativos en el contexto económico global. Los hallazgos del estudio pueden utilizarse tanto en la planificación estratégica a nivel de distritos federales como en investigaciones adicionales a nivel nacional e interregional.Исследование посвящено пространственному развитию Сибири и Дальнего Востока России. Рассмотрена роль федеральных округов как установленных макрорегионов-в оптимизации территориального планирования и коррекции субъектов межрегионального управления, а также изоляции на их основе проектных федеральных территорий - как объектов устойчивого-безопасного пространственного развития. Основное внимание уделяется формированию перспективной пространственной (инфраструктурной) основы развития макрорегионов, в том числе выявлению опережающих узлов роста (так называемых “вторых” и “третьих” городов макрорегионов) и связей между ними (транспортных осей и коридоров), значимых в глобальном экономическом контексте. Результаты исследования могут быть использованы как в области стратегического планирования на уровне федеральных округов и в дальнейших исследованиях на национальном и межрегиональном уровнях

The Specificity of the Differential Regulation of Economic Integration in the Context of Contemporary Labor Migration

The issues of integration in the modern world become relevant in the rapidly changing geopolitical realities, and the strategic imperative of time for the vast majority of States. Today in accordance with the principle of multi-level and various-speed integration on Eurasian space are successfully developing various integration formats. They complement each other to provide a wide partnership platform. The authors argue that the main participants in labor migration in the post-Soviet space reflect the actual path of social and economic interaction worked out historically. Common historical fate and similar paths of development, similar mental conceptosphere steel trigger mechanism for the implementation of the Eurasian Economic Union. Researches show that labour of migrant workers from different countries is widely distributed in different sectors of Russia's economy, their labour is used almost everywhere. In many industries a mechanism was established where officially Russian workers are registered at enterprises, but foreign migrant workers are actually employed. Russians began to actively move, migration processes have increased substantially, new forms of temporary migration. These processes have become more active throughout Eurasia. The authors analyze the causes and characteristics of migration in the Eurasian economic union at the present stage. DOI: 10.5901/mjss.2015.v6n3p9

Status Report of the DPHEP Study Group: Towards a Global Effort for Sustainable Data Preservation in High Energy Physics

Data from high-energy physics (HEP) experiments are collected with significant financial and human effort and are mostly unique. An inter-experimental study group on HEP data preservation and long-term analysis was convened as a panel of the International Committee for Future Accelerators (ICFA). The group was formed by large collider-based experiments and investigated the technical and organisational aspects of HEP data preservation. An intermediate report was released in November 2009 addressing the general issues of data preservation in HEP. This paper includes and extends the intermediate report. It provides an analysis of the research case for data preservation and a detailed description of the various projects at experiment, laboratory and international levels. In addition, the paper provides a concrete proposal for an international organisation in charge of the data management and policies in high-energy physics

Long terminal repeats of human endogenous retrovirus K family (HERV-K) specifically bind host cell nuclear proteins

AbstractSolitary long terminal repeats (LTRs) of the human endogenous retroviruses, scattered in several thousand copies throughout the human genome, are potentially capable of affecting the expression of closely located genes. To assess their regulatory potential, the LTR sequences of one of the most abundant HERV families (HERV-K) were screened for the presence of binding sites for the host cell nuclear factors using mobility shift and UV-crosslinking assays. It was shown that the LTR sequences of two subfamilies harbor a specific binding site for a complex consisting of at least three proteins, ERF1, ERF2 and ERF3 of 98, 91 and 88 kDa apparent molecular mass, respectively. This binding site is located in the 5′ region of the LTR U3 element. The preservation of the specific protein binding site in different HERV-K LTR sequences suggests their possible role in regulation of nearby located genes

Chemokine Homeostasis in Healthy Volunteers and during Pancreatic and Colorectal Tumor Growth in Murine Models

Chemokines are involved in the humoral regulation of body homeostasis. Changes in the blood level of chemokines were found in cancer, atherosclerosis, diabetes, and other systemic diseases. It is essential to distinguish the effects of co-morbid pathologies and cancer on the level of chemokines in the blood. We aimed to analyze, by multiplex cytometry, the levels of chemokines in the blood of healthy young volunteers as well as of intact mice and mice with CT26 colon and Pan02 pancreatic tumors. Two types of chemokines were identified both in human and murine plasmas: homeostatic ones, which were found in high concentrations (>100 pg/mL), and inducible ones, which can be undetectable or determined at very low levels (0–100 pg/mL). There was a high variability in the chemokine levels, both in healthy humans and mice. To analyze chemokine levels during tumor growth, C57BL/6 and BALB/c were inoculated with Pan02 or CT26 tumor cells, accordingly. The tumors significantly differed in the growth and the mortality of mice. However, the blood chemokine levels did not change in tumor-bearing mice until the very late stages. Taken collectively, blood chemokine level is highly variable and reflects in situ homeostasis. Care should be taken when considering chemokines as prognostic parameters or therapeutic targets in cancer

A map of nuclear matrix attachment regions within the breast cancer loss-of-heterozygosity region on human chromosome 16q22.1

AbstractThere is abundant evidence that the DNA in eukaryotic cells is organized into loop domains that represent basic structural and functional units of chromatin packaging. To explore the DNA domain organization of the breast cancer loss-of-heterozygosity region on human chromosome 16q22.1, we have identified a significant portion of the scaffold/matrix attachment regions (S/MARs) within this region. Forty independent putative S/MAR elements were assigned within the 16q22.1 locus. More than 90% of these S/MARs are AT rich, with GC contents as low as 27% in 2 cases. Thirty-nine (98%) of the S/MARs are located within genes and 36 (90%) in gene introns, of which 15 are in first introns of different genes. The clear tendency of S/MARs from this region to be located within the introns suggests their regulatory role. The S/MAR resource constructed may contribute to an understanding of how the genes in the region are regulated and of how the structural architecture and functional organization of the DNA are related

A new technique for selective identification and mapping of enhancers within long genomic sequences

We report a new experimental method of direct selection, identification, and mapping of potential enhancer sequences within extended stretches of genomic DNA. The method allows simultaneous cloning of a quantity of sequences instead of tedious screening of the separate ones, thus providing a robust and high-throughput approach to the mapping of enhancers. The selection procedure is based on the ability of such sequences to activate a minimal promoter that drives expression of a selective gene. To this end a mixture of short DNA fragments derived from the segment of interest was cloned in a retroviral vector containing the neomycin phosphotransferase II gene under control of a cytomegalovirus (CMV) minimal promoter. The pool of retroviruses obtained was used to infect HeLa cells and then to select neomycin-resistant colonies containing constructs with enhancer-like sequences. The pool of the genomic fragments was rescued by PCR and cloned, forming a library of the potential enhancers. Fifteen enhancer-like fragments were selected from 1-Mb human genome locus, and enhancer activity of 13 of them was verified in a transient transfection reporter gene assay. The sequences selected were found to be predominantly located near 5′ regions of genes or within gene introns