1 research outputs found
Remote Activation of the Nucleophilicity of Isatin
The
concept of the remote activation of reactivity was first applied
in asymmetric organocatalysis. An isatin 3-phenylimine derivative
acts as a donor in the thiourea catalyzed asymmetric addition to unsaturated
1,4-ketoesters, affording aza-Michael adducts in high enantiomeric
purity and yield