Investigation d'infections et/ou colonisations à Pseudomonas aeruginosa 06 imipénem résistant dans les services de réanimation du CHU de Dijon

DIJON-BU Médecine Pharmacie (212312103) / SudocSudocFranceF

Etude de la contamination environnementale aérienne d'Aspergillus au cours de la construction d'un chantier hospitalier

DIJON-BU Médecine Pharmacie (212312103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Investigation des cas d'infection et/ou colonisation à Escherichia coli producteur d'une ß-lactamase à spectre élargi de la famille des CTX-M

DIJON-BU Médecine Pharmacie (212312103) / SudocSudocFranceF

Evolution de l'incidence des bactéries multi-résistantes et de sa répartition de 1998 à 2010 au Centre Hospitalier Universitaire de Dijon

DIJON-BU Médecine Pharmacie (212312103) / SudocSudocFranceF

In reply: Is the optic nerve head structure impacted by a diagnostic lumbar puncture in humans?

Response to Letter to the Editor.International audienc

Detection of perilymphatic fistula in labyrinthine windows by virtual endoscopy and variation of reconstruction thresholds on CT scan

International audienc

Development and validation of a risk predictor nomogram for poor functional response one year after treatment with antiVEGF in naive diabetic macular edema

International audienc

Development and validation of a risk predictor nomogram for poor functional response one year after treatment with antiVEGF in naive diabetic macular edema

International audienc

T054 - Development and validation of a risk-prediction nomogram for good functional response one year after treatment with anti-VEGF in naive-diabetic macular edema

National audienc

Uni-, Bi- or Trifocal Hepatocellular Carcinoma in Western Patients: Recurrence and Survival after Percutaneous Thermal Ablation

Multifocality is usually reported as a pejorative factor after percutaneous thermal ablation (PTA) of HCC but little is known in Western series. Recurrence and survival were extracted from a prospective database of all patients who underwent PTA for ≤3 cm HCC. From January 2015 to April 2020, we analyzed 281 patients with unifocal (n = 216), bifocal (n = 46) and trifocal (n = 16) HCC. PTA of bi- and trifocal HCC resulted in a high risk of very early (<6 months) distant recurrence (38.8% and 50%, respectively). Median RFS was 23.3 months (95% CI:18.6–30.4), 7.7 months (95% CI:5.1–11.43, p = 0.002) and 5.2 months (95% CI:3–12.3, p = 0.015), respectively, for uni-, bi- and trifocal HCC groups. In a multivariate analysis, both bifocal (HR = 2.46, p < 0.001) and trifocal (HR = 2.70, p = 0.021) vs. unifocal HCC independently predicted shorter RFS. Median OS in trifocal HCC group was 30.3 months (95 CI:19.3-not reached). Trifocal vs. unifocal HCC independently predicted shorter OS (HR = 3.30, p = 0.008), whereas bifocal vs. unifocal HCC did not (p = 0.27). Naïve patient (HR = 0.42, p = 0.007), AFP > 100 ng/mL (HR = 3.03, p = 0.008), MELD > 9 (HR = 2.84, p = 0.001) and steatotic HCC (HR = 0.12, p = 0.038) were also independent predictors of OS. In conclusion, multifocal HCCs in a Western population have a dramatically increased risk of distant recurrence. OS after PTA of trifocal HCC is significantly below what was expected after a curative treatment