Su ürünlerinde kalitenin belirlemesinde biyiokimyasal yöntemlerin karşılaştırılması

Comparison of biochemical methods for determination of seafood quality. Most freshness test seafood are based on measuring major physical and chemical alteration from the original condition of the fish. Metabolites from microbial and metabolic action can be used in biochemical analyses to assess the seafood quality. These compounds are acids, amines and bases and there is little or no change in early storage stages. However, examination of nucleotide degradiation in fish muscle for assessing seafood freshness is more valuable quality index. Hypoxanthine formation is a result of both autolytic and bacterial activites and the level of hypoxanthine in seafood is a good indicator of quality.Su ürünlerinde tazeliğin belirlenmesi fiziksel ve kimyasal değişikliklerin incelenmesine dayanmaktadır. Mikrobiyal ve metabolik faaliyet sonucu oluşan metabolitler su ürünlerinde kalitenin tayin edilmesi amacıyla kullanılırlar. Bu bileşikler asitler, bazlar ve aminler gibi uçucu bileşiklerdir ve depolamanın başlangıç basamaklarında miktarlarında önemli bir artış gözlenmez. Bununla birlikte kasdaki nükleotid yıkımının incelenmesi su ürünlerinde tazeliğin belirlenmesinde önemli bir kalite indeksidir. Hipoksantin oluşumu otolitik ve bakteriyel aktiviteye dayanır ve nükleotid yıkım ürünü olan hipoksantin miktarı önemli bir tazelik indikatörüdür

Efficient synthesis of chromeno[2,3-b]pyridine derivatives using Zn(OTf)2 as a catalyst: DFT computations, molecular docking and ADME studies

An efficient method was developed for the synthesis of chromeno[2,3-b]pyridine derivatives by using Zn(OTf)2 (Zinc trifluoromethanesulfonate) via one-pot [3 + 3] cascade annulation methods using 2-amino-4H-chromen-4-one with a different substituted group (1–6) and trans-chalcone. This strategy offers the pharmacological importance of 2-amino-4H-chromen-4-one derivatives in reaction time and good yields. This approach also brings a different perspective to the literature as an intramolecular cyclization pathway. All computational works were performed at the B3LYP/6–311++G** level of theory. After confirming the optimized structures and comparing the calculated spectroscopic data with corresponding experimental data, the intramolecular interactions were evaluated on the basis of NBO “Natural Bond Orbital” theory. The quantum chemical reactivity features and FMO “Frontier Molecular Orbital” analyses were conducted at the same level of theory. The solvent effect on the reactivity behaviors was also investigated by using the results that were determined by obtaining the different solvent environments. Molecular docking was employed to explore the binding affinities of the compounds against AChE (Acetylcholinesterase), BuChE (Butyrylcholinesterase), and HSA (Human serum albümin). Also, the bioavailability and drug-likeness properties of compounds 1–6 were determined to explore the possible usage in further drug design works. © 2023 Elsevier B.V.Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 112 T503; Tekirdağ Namık Kemal Üniversitesi, TNKUFinancial support for this research from the Scientific and Technological Research Council of Turkey (TUBITAK Project No. 112 T503). The authors thank Namık Kemal University for the analysis of our article structure. All calculations have been carried out at TUBITAK ULAKBIM, High Performance and Grid Computing Center (TR-Grid e-Infrastructure).Financial support for this research from the Scientific and Technological Research Council of Turkey (TUBITAK Project No. 112 T503). The authors thank Namık Kemal University for the analysis of our article structure. All calculations have been carried out at TUBITAK ULAKBIM, High Performance and Grid Computing Center (TR-Grid e-Infrastructure)

Extreme delta brush activity: Could it be a marker for early diagnosis and prognosis of anti-nmda (n-methyl-d-aspartate) encephalitis? [Aşırı delta brush aktivitesi anti-nmda (N-metil-d-aspartat) ensefalitinde erken tanı ve prognoz için bir belirteç olabilir mi?]

2-s2.0-85088966607Autoimmune encephalitis should be excluded in unexplained en-cephalitis. A significant portion of autoimmune encephalitis in childhood is anti-NMDA encephalitis. However, neuroimaging and routine diagnostic tests are inadequate, diagnosis sholud be confirmed by the demonstration of autoantibodies. The treatment may be delay in this process. Extreme delta brush waves are unique electroencephalography pattern, seen in some of An-ti-NMDA encephalitis, useful for early diagnosis. Extreme delta brush activity is associated with prolonged hospitalization and illness. Despite of these, the specificity and sensitivity of this pattern is not-known clearly. We present a five years old boy with the loss of consciousness, involuntary movements, intermittant gen-eralized tonic clonic seizures and extreme delta brush activity in electroencephalography. © 2019 by Turkish Pediatric Association