BIM Adoption in the Cambodian Construction Industry: Key Drivers and Barriers

Critical issues surrounding the promotion and adoption of building information modeling (BIM) for construction projects are largely country-specific due to contextual socio-cultural, economic, and regulatory environments impacting construction operations and outcomes. There is little information on BIM adoption issues specific to the Cambodian construction industry (‘the industry’). This paper aims to narrow existing knowledge by investigating key drivers for, and barriers to the adoption of BIM in the industry. Using descriptive survey method, feedback was received from contractors and architects that were registered with their respective trade and professional associations in the industry. The multi-attribute method and the Statistical Package for the Social Sciences (SPSS)-based Kendall’s coefficient of concordance (W) test were used to analyze the empirical datasets. Results showed that out of the 13 significant drivers identified in the study, the most influential comprised the technology’s ability to remarkably enhance project visualization and schedule performance; this is followed by awareness that the technology is redefining how project information is created and shared among stakeholders and therefore the future of the industry that cannot be ignored. On the other hand, the most constraining barrier to the adoption of the technology, out of 19 significant barriers, related to strong industry resistance to change, especially reluctance to change from 2D drafting to 3D modeling; other highly rated barriers included the high initial cost of the software and the shortage of professionals with BIM skills. Implementation of the study findings could support greater uptake of the technology and the leveraging of its key benefits to improving project success and the growth of the Cambodian construction industry, as well as those of other developing economies that share similar socio-cultural, economic, and regulatory environments

Ab Initio Structural Energetics of Beta-Si3N4 Surfaces

Motivated by recent electron microscopy studies on the Si3N4/rare-earth oxide interfaces, the atomic and electronic structures of bare beta-Si3N4 surfaces are investigated from first principles. The equilibrium shape of a Si3N4 crystal is found to have a hexagonal cross section and a faceted dome-like base in agreement with experimental observations. The large atomic relaxations on the prismatic planes are driven by the tendency of Si to saturate its dangling bonds, which gives rise to resonant-bond configurations or planar sp^2-type bonding. We predict three bare surfaces with lower energies than the open-ring (10-10) surface observed at the interface, which indicate that non-stoichiometry and the presence of the rare-earth oxide play crucial roles in determining the termination of the Si3N4 matrix grains.Comment: 4 Pages, 4 Figures, 1 tabl

The impact assessment of cage aquaculture on benthic communities along the south eastern Black Sea

The present study was conducted to examine the impact of cage aquaculture on benthic communities in coastal areas (depth 25 to 50 m) from fish farming operations located along the southeastern Black Sea (Ordu-Perşembe, Trabzon-Yomra and Rize central). Sampling was conducted seasonally from April 2007 to 2009. Sediment samples were taken using Ekman Grab (box core- 0.04 m2). Temperature, salinity, and water velocity were periodically measured to determine influencing sedimentary organic matter in the sediment, oxygenation, and anoxic conditions. In addition, grain size of sediment, organic carbon content, and distribution of benthic communities were investigated. In order to determine benthic impact of fish farms on the region, Shannon – Wiener diversity index (H’), AMBI (AZTI Marine Biotic Index) and M-AMBI (Multivariate- Marine Biotic Index) indices were used. Results of current study showed that benthic zone ecological quality of stations with number 01, 02, 03, and 04 at Ordu-Perşembefish-farming habitat was found to be very low. In autumn 2008, there were 3 species which belonged to Capitella capitata (844 individuals/m2), Capitella sp. (133 individuals/m2), and Heteromastus filliformis (311 individuals/m2) at OP-01 station. In addition, the impact of Trabzon-Yomra fish-farming activity on benthic communities was low. The degree of exposure for Rize fish-farming area in all seasons was quite low, which was not a significant negative impact

Age-Specific Signatures of Glioblastoma at the Genomic, Genetic, and Epigenetic Levels

Age is a powerful predictor of survival in glioblastoma multiforme (GBM) yet the biological basis for the difference in clinical outcome is mostly unknown. Discovering genes and pathways that would explain age-specific survival difference could generate opportunities for novel therapeutics for GBM. Here we have integrated gene expression, exon expression, microRNA expression, copy number alteration, SNP, whole exome sequence, and DNA methylation data sets of a cohort of GBM patients in The Cancer Genome Atlas (TCGA) project to discover age-specific signatures at the transcriptional, genetic, and epigenetic levels and validated our findings on the REMBRANDT data set. We found major age-specific signatures at all levels including age-specific hypermethylation in polycomb group protein target genes and the upregulation of angiogenesis-related genes in older GBMs. These age-specific differences in GBM, which are independent of molecular subtypes, may in part explain the preferential effects of anti-angiogenic agents in older GBM and pave the way to a better understanding of the unique biology and clinical behavior of older versus younger GBMs

GliomaPredict: a clinically useful tool for assigning glioma patients to specific molecular subtypes

<p>Abstract</p> <p>Background</p> <p>Advances in generating genome-wide gene expression data have accelerated the development of molecular-based tumor classification systems. Tools that allow the translation of such molecular classification schemas from research into clinical applications are still missing in the emerging era of personalized medicine.</p> <p>Results</p> <p>We developed GliomaPredict as a computational tool that allows the fast and reliable classification of glioma patients into one of six previously published stratified subtypes based on sets of extensively validated classifiers derived from hundreds of glioma transcriptomic profiles. Our tool utilizes a principle component analysis (PCA)-based approach to generate a visual representation of the analyses, quantifies the confidence of the underlying subtype assessment and presents results as a printable PDF file. GliomaPredict tool is implemented as a plugin application for the widely-used GenePattern framework.</p> <p>Conclusions</p> <p>GliomaPredict provides a user-friendly, clinically applicable novel platform for instantly assigning gene expression-based subtype in patients with gliomas thereby aiding in clinical trial design and therapeutic decision-making. Implemented as a user-friendly diagnostic tool, we expect that in time GliomaPredict, and tools like it, will become routinely used in translational/clinical research and in the clinical care of patients with gliomas.</p

Y chromosome microdeletions in infertile men with idiopathic oligo- or azoospermia

About 30–40% of male infertility is due to unknown reasons. Genetic contributions to the disruption of spermatogenesis are suggested and amongst the genetic factors studied, Y chromosome microdeletions represent the most common one. Screening for microdeletions in AZFa, b and c region of Y chromosome showed a big variation among different studies. The purpose of this study was to investigate the prevalence of such deletions in Saudi men. A total of 257 patients with idiopathic oligo- or azoospermia were screened for Y chromosome microdeletions by 19 markers in AZF region. Ten (3.9%) patients had chromosomal rearrangements, six of them showed sex chromosome abnormalities and four patients had apparently balanced autosomal rearrengements. Eight of the remaining 247 patients (3.2%) with a normal karyotype and no known causes of impaired spermatogenesis had Y chromosome microdeletions. Among these, six patients had deletions in AZFc region, one case had a deletion in AZFb and another had both AZFa and AZFc deletions. In conclusion, our study shows that Y chromosome microdeletions are low in our population. We also report for the first time a case with unique point deletions of AZFa and AZFc regions. The lower frequency of deletions in our study suggest that other genetic, epigenetic, nutritional and local factors may be responsible for idiopathic oligo- or azoospermia in the Saudi population