Evaluation of cognitive impairment in rheumatoid arthritis: predictive value of joint destruction and disease activity

AMAÇ: Romatoid Artrit (RA), oryantasyon, dikkat ve bellek zayıflığı gibi azalmış bilişsel işlevlere neden olur. Sunulan bu çalışmanın amacı RA’da bilişsel işlevlerin bir belirleyicisi olarak eklem yıkımını ve hastalığın diğer parametrelerini değerlendirmektir. GEREÇ VE YÖNTEM: Bu kesitsel çalışma, 45 hasta ve 40 sağlıklı kontrol içemektedir. RA’lı hastalarda radyolojik progresyon skoru (≥0.5, modifiye Sharp / van der Heijde skorları- MTS’ler), 28 eklemin hastalık aktivite skoru (DAS-28) ve 44 eklemin hastalık aktivite skoru (DAS-44) değerlendirildi. Mini Mental Test (MMSE) ve Hastane Anksiyete Depresyon Ölçeği (HADÖ) değerlendirildi. Sonuçlar, bilişsel işlevleri belirlemek için hasta ve kontrol grubu arasında karşılaştırıldı. BULGULAR: MMSE skorları açısından gruplar arasında istatistiksel olarak anlamlı fark vardı (p=0.003). RA ve kontrol grupları arasında anksiyete ve depresyon düzeyleri açısından anlamlı farklılık yoktu. MMSE skoru; hastalık süresi (p=0.011, r=-0.371), Sharp skoru (p=0.018, r=-0.350) ve DAS-28(p=0.044, r=-0.296) skoru ile ilişkilendirildi. Depresyon skoru da DAS ile ilişkiliydi (p=0.004, r=0.425). Romatoid faktör düzeyleri, antisiklik sitrullinat peptid düzeyleri ve bilişsel işlev testleri arasında herhangi bir ilişki bulunamadı. SONUÇ: Sonuçlar, uzun süredir RA olan hastalarda inflamatuar mediatörlere maruz kalmanın, eklemleri etkilediği sürece merkezi sinir sisteminde de bozulmaya neden olabileceğini göstermektedir. Bilişsel bozulma, hastalık şiddeti ve eklem yıkımı ile ilişkili idi. Dolayısıyla, radyografik eklem hasarı, RA’daki bu kronik süreç boyunca nöronal hasarın ve bilişsel bozulmanın boyutunu yansıtan pozitif bir ön belirteç olabilir.OBJECTIVE: Rheumatoid Arthritis (RA) cause poor cognitive functions including reduced memory, orientation and attention. The aim of the present study is to evaluate joint destruction and other parameters of disease as a predictor of cognitive functions in RA. MATERIAL AND METHODS: This cross-sectional study included forty five patients and forty healthy controls. Radiological progression score (≥0.5 the modified Sharp/ van der Heijde scores- MTSs), disease activity score of 28 joints (DAS-28) and disease activity score of 44 joints (DAS-44) were evaluated in patients with RA. Mini Mental State Examination (MMSE) and Hospital Anxiety Depression Scale (HADS) were evaluated and the results were compared between patients and control groups to determinate cognitive functions. RESULTS: There was a statistically significant difference between groups in terms of MMSE scores (p=0.003). There were no significant differences in terms of anxiety and depression levels between RA and control groups. MMSE score was correlated with disease duration (p=0.011, r=- 0.371), Sharp score (p=0.018, r=-0.350) and DAS-28 score (p=0.044, r=-0.296). Depression score was also correlated with DAS (p=0.004, r=0.425). No relationship was found between Rheumatoid factor levels, anti-cyclic citrullinated peptide levels and the cognitive function tests. CONCLUSIONS: The results indicate that exposure to inflammatory mediators in patients with long standing RA may lead to deterioration on central nervous system as long as affecting joints. Cognitive deterioration was correlated with disease severity and joint destruction. Thus, the radiographic joint destruction can be a positive predictor of reflecting the extent of neuronal damage and cognitive deterioration during this chronic process in RA

The Relationship Between Serum Pentraxine 3 Levels and Hematological Markers in Patients With Rheumatoid Arthritis

Conclusion: We found no correlation between PTX3 and disease activity score 28 or NLR, although PTX3 levels were higher in RA patients than the controls. As a result, we were unable to establish a relationship between PTX3 and disease activity, directly or indirectly. To our knowledge, our study was the first to investigate the relationship between PTX3 and NLR

The Evaluation of Serum Tumor Necrosis Factor-Like Weak Inducer of Apoptosis, Interleukin-6, Fetuin-A, Homeostatic Model Assessment-Insulin Resistance, and Insulin Levels in Rheumatoid Arthritis Patients in Clinical Remission

Conclusion: We found that RA patients had lower sTWEAK levels and higher fetuin-A levels than the control group subjects. Furthermore, these two molecules were associated with each other. This study demonstrated that in RA patients, even if the disease is controlled with treatment, some molecules associated with an increased metabolic and cardiovascular risk continue to function. Follow-up studies on larger populations are warranted to confirm these findings

Kanatlı Sektöründe Atık Sorunu ve Çevresel Etkileri

Tarımsal Araştırmalar ve Politikalar Genel Müdürlüğünce Bolu Valiliği işbirliği, Müdürlüğümüz ile Toprak Gübre ve Su Kaynakları Merkez Araştırma Müdürlüğü organizatörlüğünde düzenlenen çalıştaya katkı yapan dernek, firma yetkililerine ve sundukları tebliğler ile bizleri bilgilendiren konuşmacılara teşekkür ederim

Method of Chick Quality Evaluation and Novel Approach in Increasing Chick Quality

Chick quality is rather important in poultry industry. Performance values of high quality chicks are higher during production stage. Genetic structure of the breeding flock, rearing systems, flock management, nutrition, hatching conditions and diseases all affect the chick quality. Various methods were developed with the aim of measuring the chick quality. Among these methods are visual evaluation, body weight, body mass without yolk (BMWY), chick length, product ratio, tona score and pasgar score. Hatching machine manufacturers have developed novel methods with the aim of determining egg weight losses and shell temperature. With these systems it is aimed to decrease the negative effects arised from hatcheries on chick quality

Determination of Proper Turning Frequency to Increase for Hatching Results in Hatching Eggs With Abnormal Shape Index

The aim of this study was to determine the optimum turning frequency for increasing the hatchability results in hatching eggs with abnormal shape index. For this purpose, 4050 hatching eggs obtained from 56 weeks old ATAK-S hybrid hens were used. Shape index was divided into 3 groups as 71 and smaller, 72 - 76, 77 and higher. The research was conducted according to a completely randomized factorial experimental design. The hatching eggs were incubated with turning frequency of 30, 60 and 120 minutes. In the present study, fertility rate, hatchability, hatch of fertile, early, middle, late embryonic mortality, discard chick rate, chick quality, malformation and malposition rates were determined. The turning frequency was found to have a significant effect on hatch of fertile eggs and late embryonic mortality. It was found that turning frequency and shape index had no significant effect on the hatching results regarding discarded chicks, early embryonic mortality, malposition, malformation rate, and chick quality. Interaction between egg shape index and turning frequency did not influence hatching traits and chick quality. It was determined that there was no interaction effect between turning frequency and shape index on all the characteristics discussed. According to the results obtained from the research, it was observed that the 30 and 120 minute turning frequency of hatching eggs with different shape indexes had a negative effect on the hatchability of fertile eggs and late embryo mortality. It was concluded that even if the shape index of the hatching eggs were different, the optimum turning frequency should be every 60 minutes

Effect of Some Egg Quality Traits on Hatching Results in Brown Pure Lines

This study was conducted to determine the influence of eggshell thickness, albumen height, yolk height and haugh unit on hatching results. A total of 746 eggs, which were obtained and evaluated for egg quality parameters from 100 brown pure line hens of 42 weeks of age, were used. Eggs were collected from each hen for 12 days and individual incubation was carried out. Eggs were grouped based on quality parameters and evaluated accordingly. The findings suggested that hatchability, hatchability of fertile eggs, early, mid and late embryonic mortality did not differ in terms of haugh unit, albumen height, eggshell thickness and yolk height groups. However, early embryonic mortality was found different between the yolk height groups. No relationship was determined among albumen height, haugh unit, eggshell thickness and hatching results. There was no relation between yolk height and hatchability of fertile eggs, hatchability, mid and late embryonic mortalities but was a positive correlation with early embryonic mortality. The results of the present study demonstrate that egg quality parameters studied here had no influence on hatching results except that early embryonic mortality increased with the yolk height

Beyaz Yumurtacı Ebeveyn Hatlarında İkili Melez Kombinasyonların Bazı Verim ve Yumurta Kalite Özellikleri Bakımından Karşılaştırılması

Araştırma beyaz yumurtacı ebeveynlerin değişik kombinasyonlarda melezlenerek uygun melez kombinasyonunu tespit etmek üzere yapılmıştır. Bu amaçla Tavukçuluk Araştırma Enstitüsünde bulunan HTBLC, HTBRV ve YTDLY kodları verilen ebeveyn hatlarından HTBLC * YTDLY ve HTBRV*YTDLY melezleri elde edilerek verim ve yumurta kalite özellikleri belirlenmiştir. Araştırma 80 haftalık verim dönemi boyunca sürdürülmüş olup her bir melezden 100 adet olmak üzere toplam 200 adet tavuk kullanılmıştır. Üzerinde durulan verim ve yumurta kalite özelliklerinden yaşama gücü, yumurta ağırlığı, 80. hafta canlı ağırlığı, ak yüksekliği ve haugh birimi bakımından melez kombinasyonları arasındaki farklılığın önemli olduğu, buna karşın tavuk-gün yumurta verimi, piliç ve yumurtlama dönemi yem tüketimi, dönem başı canlı ağırlığı, 72. hafta canlı ağırlığı, kabuk kalınlığı ve kabuk direnci bakımından önemli farklılık bulunmadığı tespit edilmiştir. Elde edilen sonuçlara göre yaşama gücü değerleri hariç diğer özellikler bakımından HTBRV*YTDİY melez kombinasyonunun daha iyi sonuç verdiği belirlenmiştir

Effect of Egg Orientation on Malposition in Hatching Eggs

This research was conducted to determine the effects of orientation in the hatching eggs on hatching results and position disorders, so the eggs were placed in incubator for 3 groups as orientation of normal, horizontal and small end up. In this study, 1680 hatching eggs were divided into 3 groups with 7 replicates of 80 eggs in each. Hatchability of fertile eggs, malformation ratio, malposition ratio, weight loss ratio, chick quality, embryo death ratios in the early, middle and late stage of embriogenesis and mortality ratio were investigated in this research. There were significant differences among the groups in terms of egg weight loss ratio, embryo death in the late stage of embriogenesis, malposition ratio, hatching rate , whereas no significant differences among the groups in respect to malformation ratio, chick quality, embryo death in early and late embriogenesis. It was determined that the late embrionic mortality increased because of the position errors in case of hatching eggs orientation and the head of the embryo in small end up of eggs

Relationship of work disability between the disease activity, depression and quality of life in patients with ankylosing spondylitis

CONCLUSION: In this study, we determined that AS had a significant influence on the working conditions and the factors related to the disease had a significant correlation with work productivity. Factors related to the psychology and the disease were also correlated with the working conditions