Immunorehabilitology: Sources, Present and Perspectives. From Immunotherapy to Personalized Targeted Immunorehabilitation

Development and introduction of modern clinical diagnostic tests (that allow to evaluate the functional system of immune homeostasis) into medical practice, a huge body of evidence on the leading role of the immune system in pathogenesis most acute and chronic diseases and even identification of specific nosological forms of immune-mediated diseases forced the scientists to search and develop new tools and techniques that have therapeutic effects on the impaired immune homeostasis and restore it to the normal state. The introduction of a novel concept -immunorehabilitation -was an impetus for the accumulation of new knowledge and a catalyst for research in clinical immunology. The first papers on this topic were published over 30 years ago [ 6, 8-11, 15, 17]. It was Revaz Sepiashvili who breathed life into the concept of immunorehabilitation. He was lucky to be at its origin. He became not only the founder of the brand new scientific field -immunorehabilitation, but also the founder of a new medical science -immunorehablitology. In this paper, the author returns to the roots and recalls the way that medical science has gone before coming to understand immunorehablitology and tells readers about current successes and its development prospects

IMMUNOREHABILITOLOGY: A LOOK FROM THE SOURCES TO THE FUTURE. FROM IMMUNOTHERAPY TO PERSONALIZED TARGETED IMMUNOREHABLITATION

Development and introduction of modern clinical diagnostic tests (that allow to evaluate the functional system of immune homeostasis) into medical practice, a huge body of evidence on the leading role of the immune system in pathogenesis most acute and chronic diseases and even identification of specific nosological forms of immune-mediated diseases forced the scientists to search and develop new tools and techniques that have therapeutic effects on the impaired immune homeostasis and restore it to the normal state. The introduction of a new concept - immunorehabilitation - was an impetus for the accumulation of new knowledge and a catalyst for research in clinical immunology. It was Revaz Sepiashvili who breathed life into the concept of immunorehabilitation. He was lucky to be at its origi. He became not only the founder of the brand new scientific field - immunorehabilitation, but also the founder of a new medical science - immunorehablitology. In this paper, the author returns to the roots and recalls the way that medical science has gone before coming to understand immunorehablitology and tells readers about current successes and its development prospects

BASIC PRINCIPLES AND METHODS TO THE USE IMMUNOMODULATING PREPARATIONS IN CLINICAL PRACTICE: CLASSIFICATION, INDICATIONS AND CONTRAINDICATIONS

This paper is devoted to one of the most pressing issues in modern clinical medicine, the problem of immunomodulators and immunotropic therapy. The materials presented are the logical sequel of the papers published by Revaz I. Sepiashvili in 2001-2015. In these articles, the author proposed the first classification of immunotropic preparations, a brief historical background and chronological emergence of the concept of therapies, as well as definition of immunomodulators. This paper presents an updated classification of immunomodulatory drugs which is valid for January 2015. The paper also outlines basic principles for therapies that allow the clinician not only to select a proper immunomodulator but also to develop strategy and tactics in treatment of the patient, taking into account his/her individual characteristics and the need to use in clinical practice only officially registered immunotropic preparations

Immunorehabilitology: Sources, Present and Perspectives. From Immunotherapy to Personalized Targeted Immunorehabilitation

Development and introduction of modern clinical diagnostic tests (that allow to evaluate the functional system of immune homeostasis) into medical practice, a huge body of evidence on the leading role of the immune system in pathogenesis most acute and chronic diseases and even identification of specific nosological forms of immune-mediated diseases forced the scientists to search and develop new tools and techniques that have therapeutic effects on the impaired immune homeostasis and restore it to the normal state. The introduction of a novel concept -immunorehabilitation -was an impetus for the accumulation of new knowledge and a catalyst for research in clinical immunology. The first papers on this topic were published over 30 years ago [ 6, 8-11, 15, 17]. It was Revaz Sepiashvili who breathed life into the concept of immunorehabilitation. He was lucky to be at its origin. He became not only the founder of the brand new scientific field -immunorehabilitation, but also the founder of a new medical science -immunorehablitology. In this paper, the author returns to the roots and recalls the way that medical science has gone before coming to understand immunorehablitology and tells readers about current successes and its development prospects

BASIC PRINCIPLES AND METHODS TO THE USE IMMUNOMODULATING PREPARATIONS IN CLINICAL PRACTICE: CLASSIFICATION, INDICATIONS AND CONTRAINDICATIONS

This paper is devoted to one of the most pressing issues in modern clinical medicine, the problem of immunomodulators and immunotropic therapy. The materials presented are the logical sequel of the papers published by Revaz I. Sepiashvili in 2001-2015. In these articles, the author proposed the first classification of immunotropic preparations, a brief historical background and chronological emergence of the concept of therapies, as well as definition of immunomodulators. This paper presents an updated classification of immunomodulatory drugs which is valid for January 2015. The paper also outlines basic principles for therapies that allow the clinician not only to select a proper immunomodulator but also to develop strategy and tactics in treatment of the patient, taking into account his/her individual characteristics and the need to use in clinical practice only officially registered immunotropic preparations

IMMUNOREHABILITOLOGY: A LOOK FROM THE SOURCES TO THE FUTURE. FROM IMMUNOTHERAPY TO PERSONALIZED TARGETED IMMUNOREHABLITATION

Development and introduction of modern clinical diagnostic tests (that allow to evaluate the functional system of immune homeostasis) into medical practice, a huge body of evidence on the leading role of the immune system in pathogenesis most acute and chronic diseases and even identification of specific nosological forms of immune-mediated diseases forced the scientists to search and develop new tools and techniques that have therapeutic effects on the impaired immune homeostasis and restore it to the normal state. The introduction of a new concept - immunorehabilitation - was an impetus for the accumulation of new knowledge and a catalyst for research in clinical immunology. It was Revaz Sepiashvili who breathed life into the concept of immunorehabilitation. He was lucky to be at its origi. He became not only the founder of the brand new scientific field - immunorehabilitation, but also the founder of a new medical science - immunorehablitology. In this paper, the author returns to the roots and recalls the way that medical science has gone before coming to understand immunorehablitology and tells readers about current successes and its development prospects