1 research outputs found
Hemostatic Swabs Containing Polydopamine-like Catecholamine Chitosan-Catechol for Normal and Coagulopathic Animal Models
All animal experiments for evaluating
drug efficacy or developing
medical devices are unavoidably accompanied by bleeding that result
in unreliable outcomes with large variations between individuals.
Herein, we developed hemostatic swabs prepared by a mussel-inspired
catecholamine polymer called chitosan-catechol, which was inspired
by the chemical composition of the well-known material-independent
coating material of polydopamine. The hemostatic ability of the swabs
resulted from the formation of self-sealing membranes by rapid intermolecular
interactions between whole blood proteins and the applied chitosan-catechol.
The blood protein/chitosan-catechol composite sealing membrane resulted
in dramatic decreases in bleeding for both normal and coagulopathic
models, such as diabetes